Matches in DBpedia 2014 for { ?s ?p Atorvastatin (INN) /əˌtɔrvəˈstætən/, marketed by Pfizer as a calcium salt under the trade name Lipitor, is a member of the drug class known as statins, which are used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.Atorvastatin was first synthesized in 1985 by Bruce Roth, an alumnus of Saint Joseph's University, while he was working for the Parke-Davis Company (since acquired by Warner-Lambert and the Pfizer Company). Although Atorvastatin was the fifth drug in the class of statins to be developed, clinical trials showed that Atorvastatin caused a more dramatic reduction in LDL-C than the other statin drugs. From 1996 to 2012 under the trade name Lipitor, Atorvastatin became the world's best-selling drug of all time, with more than $125 billion in sales over approximately 14.5 years.When Pfizer's patent on Lipitor expired on November 30, 2011, generic Atorvastatin became available in the United States. Initially, Atorvastatin was manufactured only by generic drugmakers Watson Pharmaceuticals and India's Ranbaxy Laboratories. Prices for the generic version did not drop to the level of other generics—$10 or less for a month's supply—until other manufacturers were able to supply the drug in May 2012.. }
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- Atorvastatin abstract "Atorvastatin (INN) /əˌtɔrvəˈstætən/, marketed by Pfizer as a calcium salt under the trade name Lipitor, is a member of the drug class known as statins, which are used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.Atorvastatin was first synthesized in 1985 by Bruce Roth, an alumnus of Saint Joseph's University, while he was working for the Parke-Davis Company (since acquired by Warner-Lambert and the Pfizer Company). Although Atorvastatin was the fifth drug in the class of statins to be developed, clinical trials showed that Atorvastatin caused a more dramatic reduction in LDL-C than the other statin drugs. From 1996 to 2012 under the trade name Lipitor, Atorvastatin became the world's best-selling drug of all time, with more than $125 billion in sales over approximately 14.5 years.When Pfizer's patent on Lipitor expired on November 30, 2011, generic Atorvastatin became available in the United States. Initially, Atorvastatin was manufactured only by generic drugmakers Watson Pharmaceuticals and India's Ranbaxy Laboratories. Prices for the generic version did not drop to the level of other generics—$10 or less for a month's supply—until other manufacturers were able to supply the drug in May 2012.".