Matches in DBpedia 2014 for { ?s ?p Factor XIII deficiency may occur very rarely, and can cause a severe bleeding tendency. The incidence is 1 in a million to 1 in 5 million people. Most are due to mutations in the A subunit gene (located on chromosome 6p25-p24). This mutation is inherited in an autosomal recessive fashion.As Factor XIII is composed of two subunit protein A and B, for which the genes are located on different chromosomes, administration of recombinant A subunit improves clot stability and is becoming a therapeutic option for patients with this condition. This deficiency leads to defective cross-linking of fibrin and vulnerability to late re-bleeds when the primary hemostatic plug is overwhelmed. Bleeding tendencies similar to hemophiliacs develop such as hemarthroses and deep tissue bleeding.. }
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- Factor_XIII_deficiency abstract "Factor XIII deficiency may occur very rarely, and can cause a severe bleeding tendency. The incidence is 1 in a million to 1 in 5 million people. Most are due to mutations in the A subunit gene (located on chromosome 6p25-p24). This mutation is inherited in an autosomal recessive fashion.As Factor XIII is composed of two subunit protein A and B, for which the genes are located on different chromosomes, administration of recombinant A subunit improves clot stability and is becoming a therapeutic option for patients with this condition. This deficiency leads to defective cross-linking of fibrin and vulnerability to late re-bleeds when the primary hemostatic plug is overwhelmed. Bleeding tendencies similar to hemophiliacs develop such as hemarthroses and deep tissue bleeding.".