Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Linezolid> ?p ?o. }
- Linezolid abstract "Linezolid (INN, /lɪˈnɛzəlɪd/ li-NEZ-ə-lid) is a synthetic antibiotic developed by a team at Pharmacia and Upjohn Company. It is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics.A member of the oxazolidinone class of drugs, linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA). The main indications of linezolid are infections of the skin and soft tissues and pneumonia (particularly hospital-acquired pneumonia), although off-label use for a variety of other infections is becoming popular. Linezolid is marketed by Pfizer under the trade names Zyvox (in the United States, United Kingdom, Australia, and several other countries), Zyvoxid (in Europe), and Zyvoxam (in Canada and Mexico). Generics are also available, such as Linospan (in India, by Cipla) and Linzolid (in Bangladesh, by Incepta).Discovered in the 1990s and first approved for use in 2000, linezolid was the first commercially available 1,3-oxazolidinone antibiotic. As of 2009, it is the only marketed oxazolidinone, although others are in development. As a protein synthesis inhibitor, it stops the growth of bacteria by disrupting their production of proteins i.e. it is a bacteriostatic agent, not bacteriocidal. Although many antibiotics work this way, the exact mechanism of action of linezolid appears to be unique in that it blocks the initiation of protein production, and not one of the later steps. Bacterial resistance to linezolid has remained very low since it was first detected in 1999, although it may be increasing.When administered for short periods, linezolid is a relatively safe drug; it can be used in patients of all ages and in people with liver disease or poor kidney function. Common adverse effects of short-term use include headache, diarrhea, and nausea. Long-term use, however, has been associated with serious adverse effects; linezolid can cause bone marrow suppression and low platelet counts, particularly when used for more than two weeks. If used for longer periods still, it may cause sometimes irreversible chemotherapy-induced peripheral neuropathy and optic nerve damage, and lactic acidosis (a buildup of lactic acid in the body), all most likely due to mitochondrial toxicity.Linezolid is very expensive, costing approximately US$100 per pill in the United States. Nonetheless, it appears to be more cost-effective than comparable antibiotics, such as vancomycin, mostly because of the possibility of switching from intravenous to oral administration as soon as patients are stable enough, without the need for dose adjustments.".
- Linezolid atcPrefix "J01".
- Linezolid atcSuffix "XX08".
- Linezolid casNumber "165800-03-3".
- Linezolid drugbank "DB00601".
- Linezolid fdaUniiCode "ISQ9I6J12J".
- Linezolid iupacName "(S)-N-({3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide".
- Linezolid pubchem "441401".
- Linezolid thumbnail Linezolid.svg?width=300.
- Linezolid wikiPageID "424464".
- Linezolid wikiPageRevisionID "606308570".
- Linezolid align "right".
- Linezolid alt "Black and white micrograph: a band of sphere-shaped bacteria, clustered in pairs, extends across a gray field.".
- Linezolid alt "Colorized micrograph: sphere-shaped bacteria clustered in grape-like bunches.".
- Linezolid alt "Skeletal formula of linezolid".
- Linezolid atcPrefix "J01".
- Linezolid atcSuffix "XX08".
- Linezolid bioavailability "~100%".
- Linezolid c "16".
- Linezolid casNumber "165800".
- Linezolid chembl "126".
- Linezolid chemspiderid "390139".
- Linezolid direction "vertical".
- Linezolid drugbank "DB00601".
- Linezolid eliminationHalfLife "19440.0".
- Linezolid excretion "Nonrenal, renal, and fecal".
- Linezolid f "1".
- Linezolid footer "Scanning electron micrographs of vancomycin-resistant Enterococcus and methicillin-resistant Staphylococcus aureus".
- Linezolid h "20".
- Linezolid hasPhotoCollection Linezolid.
- Linezolid image "CDC-10046-MRSA.jpg".
- Linezolid image "Linezolid-from-xtal-2008-3D-balls.png".
- Linezolid image "Vancomycin-Resistant Enterococcus 01.jpg".
- Linezolid inchi "1".
- Linezolid iupacName "-N-acetamide".
- Linezolid kegg "D00947".
- Linezolid legalAu "S4".
- Linezolid legalCa "Rx-only".
- Linezolid legalUk "POM".
- Linezolid legalUs "Rx-only".
- Linezolid licenceUs "Linezolid".
- Linezolid medlineplus "a602004".
- Linezolid metabolism "Hepatic".
- Linezolid molecularWeight "337.346".
- Linezolid n "3".
- Linezolid niaidChemdb "70944".
- Linezolid o "4".
- Linezolid pregnancyAu "C".
- Linezolid pregnancyUs "C".
- Linezolid proteinBound "Low".
- Linezolid pubchem "441401".
- Linezolid routesOfAdministration "Intravenous infusion, oral".
- Linezolid smiles "O=C1O[C@@H]CN1c3ccccc3".
- Linezolid stdinchi "1".
- Linezolid stdinchikey "TYZROVQLWOKYKF-ZDUSSCGKSA-N".
- Linezolid tradename "Zyvox, Zyvoxam, Zyvoxid".
- Linezolid unii "ISQ9I6J12J".
- Linezolid verifiedfields "changed".
- Linezolid verifiedrevid "415028406".
- Linezolid width "200".
- Linezolid subject Category:2000_introductions.
- Linezolid subject Category:Monoamine_oxidase_inhibitors.
- Linezolid subject Category:Morpholines.
- Linezolid subject Category:Organofluorides.
- Linezolid subject Category:Oxazolidinone_antibiotics.
- Linezolid subject Category:Pfizer.
- Linezolid type Agent114778436.
- Linezolid type Antibacterial102716205.
- Linezolid type Antibiotic102716866.
- Linezolid type Antidepressant102718811.
- Linezolid type CausalAgent100007347.
- Linezolid type Drug103247620.
- Linezolid type Matter100020827.
- Linezolid type Medicine103740161.
- Linezolid type MonoamineOxidaseInhibitor103783017.
- Linezolid type MonoamineOxidaseInhibitors.
- Linezolid type OxazolidinoneAntibiotics.
- Linezolid type PhysicalEntity100001930.
- Linezolid type Substance100020090.
- Linezolid type Drug.
- Linezolid type DrugProduct.
- Linezolid type FunctionalSubstance.
- Linezolid comment "Linezolid (INN, /lɪˈnɛzəlɪd/ li-NEZ-ə-lid) is a synthetic antibiotic developed by a team at Pharmacia and Upjohn Company. It is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics.A member of the oxazolidinone class of drugs, linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA).".
- Linezolid label "Linezolid".
- Linezolid label "Linezolid".
- Linezolid label "Linezolid".
- Linezolid label "Linezolid".
- Linezolid label "Linezolid".
- Linezolid label "Linezolida".
- Linezolid label "Linézolide".
- Linezolid label "Линезолид".
- Linezolid label "لنزوليد".
- Linezolid label "リネゾリド".
- Linezolid label "利奈唑胺".
- Linezolid sameAs Linezolid.
- Linezolid sameAs Linezolid.
- Linezolid sameAs Linézolide.
- Linezolid sameAs Linezolid.
- Linezolid sameAs リネゾリド.
- Linezolid sameAs 리네졸리드.
