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- ATP2B3 abstract "Plasma membrane calcium-transporting ATPase 3 is an enzyme that in humans is encoded by the ATP2B3 gene.The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.".
- ATP2B3 entrezgene "492".
- ATP2B3 wikiPageID "14880622".
- ATP2B3 wikiPageRevisionID "590713881".
- ATP2B3 hasPhotoCollection ATP2B3.
- ATP2B3 requireManualInspection "no".
- ATP2B3 summaryText "The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.".
- ATP2B3 updateCitations "yes".
- ATP2B3 updatePage "yes".
- ATP2B3 updateProteinBox "yes".
- ATP2B3 updateSummary "yes".
- ATP2B3 type Biomolecule.
- ATP2B3 type Protein.
- ATP2B3 type BiologicalObject.
- ATP2B3 comment "Plasma membrane calcium-transporting ATPase 3 is an enzyme that in humans is encoded by the ATP2B3 gene.The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis.".
- ATP2B3 label "ATP2B3".
- ATP2B3 sameAs m.03h05wr.
- ATP2B3 sameAs Q4654812.
- ATP2B3 sameAs Q4654812.
- ATP2B3 wasDerivedFrom ATP2B3?oldid=590713881.
- ATP2B3 isPrimaryTopicOf ATP2B3.