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- Clone_(B-cell_biology) abstract "The process of immunological B-cell maturation involves transformation from an undifferentiated B cell to one that secretes antibodies with particular specificity. This differentiation and activation of the B cell occurs most rapidly after exposure to antigen by antigen-presenting cells in the reticuloendothelial system, and under modulation by T cells, and is closely intertwined with affinity maturation. B cells that respond most avidly to antigen are preferentially allowed to proliferate and mature, a process known as clonal selection. In lymphocytic neoplastic diseases such as multiple myeloma and lymphoma, but also other illnesses, there can be a massive expansion of a single B-cell clone, detectable by measuring the excessively-produced antibodies, measured in a serum protein electrophoresis test or peripheral blood flow cytometry. Such an expansion is said to be "monoclonal", and monoclonal antibodies produced by such a group of B cells can cause illnesses such as amyloidosis and lupus, or can be indicative of an underlying malignancy. The concept of clonality is closely associated with malignancy, for example in diagnosing lymphomatoid skin lesions. The expansion of a particular clone of immune B cells is usually interpreted by clinicians as evidence of unrestricted cell growth, the hallmark of cancer.".
- Clone_(B-cell_biology) wikiPageID "9598937".
- Clone_(B-cell_biology) wikiPageRevisionID "569963220".
- Clone_(B-cell_biology) hasPhotoCollection Clone_(B-cell_biology).
- Clone_(B-cell_biology) subject Category:Lymphocytes.
- Clone_(B-cell_biology) type BloodCell105449268.
- Clone_(B-cell_biology) type Cell100006484.
- Clone_(B-cell_biology) type FreePhagocyte105451265.
- Clone_(B-cell_biology) type Leukocyte105449959.
- Clone_(B-cell_biology) type LivingThing100004258.
- Clone_(B-cell_biology) type Lymphocyte105451384.
- Clone_(B-cell_biology) type Lymphocytes.
- Clone_(B-cell_biology) type Object100002684.
- Clone_(B-cell_biology) type Phagocyte105450888.
- Clone_(B-cell_biology) type PhysicalEntity100001930.
- Clone_(B-cell_biology) type SomaticCell105430628.
- Clone_(B-cell_biology) type Whole100003553.
- Clone_(B-cell_biology) comment "The process of immunological B-cell maturation involves transformation from an undifferentiated B cell to one that secretes antibodies with particular specificity. This differentiation and activation of the B cell occurs most rapidly after exposure to antigen by antigen-presenting cells in the reticuloendothelial system, and under modulation by T cells, and is closely intertwined with affinity maturation.".
- Clone_(B-cell_biology) label "Clone (B-cell biology)".
- Clone_(B-cell_biology) label "Klonalität".
- Clone_(B-cell_biology) sameAs Klonalität.
- Clone_(B-cell_biology) sameAs m.02pld23.
- Clone_(B-cell_biology) sameAs Q1774839.
- Clone_(B-cell_biology) sameAs Q1774839.
- Clone_(B-cell_biology) sameAs Clone_(B-cell_biology).
- Clone_(B-cell_biology) wasDerivedFrom Clone_(B-cell_biology)?oldid=569963220.
- Clone_(B-cell_biology) isPrimaryTopicOf Clone_(B-cell_biology).