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- Mefway_(18F) abstract "Mefway is a 5-HT1A receptor antagonist used in medical research, usually in the form of mefway (18F) as a positron emission tomography (PET) radiotracer. It is closely related to the research compound WAY-100,635.The compound adds a fluoromethyl group to the cyclohexyl ring of WAY-100,635.There are two isomers with regard to the cyclohexane ring, of which the trans conformation has the higher 5-HT1A specificity.In one study the uptake and retention of mefway (18F) was found to be similar to that found for 11C-WAY-100,635. Head-to-head comparison of mefway (18F) and 11C-WAY-100,635 have been evaluated. Since 11C-WAY-100,635 is the current ‘gold standard’ and difficult to synthesize, a suitable fluorine-18 replacement as in mefway is highly desired.The ability to separately measure dissociation constant, KD and receptor density Bmax has been shown to be of potential value rather than simply comparing binding potential, Bnd. Multiple injection mefway PET experiments can be used for the in-vivo measurement of 5-HT1A receptor density.Imaging studies of mefway on in vivo and ex vivo rat brains indicate that the substance binds to the known 5-HT1A receptor regions including the dorsal raphe. These findings support that the dorsal raphe is measurable in rat PET studies.".
- Mefway_(18F) atcPrefix "none".
- Mefway_(18F) casNumber "943962-60-5".
- Mefway_(18F) iupacName "4-[(18F)fluoromethyl]-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexane-1-carboxamide".
- Mefway_(18F) pubchem "11963740".
- Mefway_(18F) thumbnail Mefway_18F_skeletal.svg?width=300.
- Mefway_(18F) wikiPageID "32648867".
- Mefway_(18F) wikiPageRevisionID "546296474".
- Mefway_(18F) atcPrefix "none".
- Mefway_(18F) c "26".
- Mefway_(18F) casNumber "943962".
- Mefway_(18F) chemspiderid "10137857".
- Mefway_(18F) drugName "Mefway".
- Mefway_(18F) f "1".
- Mefway_(18F) h "35".
- Mefway_(18F) hasPhotoCollection Mefway_(18F).
- Mefway_(18F) iupacName "4".
- Mefway_(18F) legalStatus "Research compound".
- Mefway_(18F) molecularWeight "453.583".
- Mefway_(18F) n "4".
- Mefway_(18F) o "2".
- Mefway_(18F) pregnancyCategory "N/A".
- Mefway_(18F) pubchem "11963740".
- Mefway_(18F) smiles "COC1=CC=CC=C1N2CCNCCNCC4CCCC[18F]".
- Mefway_(18F) stdinchi "1".
- Mefway_(18F) stdinchikey "BQGLPDFQLBNUGU-FMLNDMEQSA-N".
- Mefway_(18F) subject Category:Amides.
- Mefway_(18F) subject Category:Dopamine_agonists.
- Mefway_(18F) subject Category:Phenol_ethers.
- Mefway_(18F) subject Category:Piperazines.
- Mefway_(18F) subject Category:Pyridines.
- Mefway_(18F) type Drug.
- Mefway_(18F) type FunctionalSubstance.
- Mefway_(18F) comment "Mefway is a 5-HT1A receptor antagonist used in medical research, usually in the form of mefway (18F) as a positron emission tomography (PET) radiotracer.".
- Mefway_(18F) label "Mefway (18F)".
- Mefway_(18F) sameAs m.0h3p4kq.
- Mefway_(18F) sameAs Q6807950.
- Mefway_(18F) sameAs Q6807950.
- Mefway_(18F) wasDerivedFrom Mefway_(18F)?oldid=546296474.
- Mefway_(18F) depiction Mefway_18F_skeletal.svg.
- Mefway_(18F) isPrimaryTopicOf Mefway_(18F).
- Mefway_(18F) name "Mefway (18F)".