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- NAD(P)H_dehydrogenase_(quinone_1) abstract "NAD(P)H dehydrogenase [quinone] 1 is an enzyme that in humans is encoded by the NQO1 gene.This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Recent pharmacological research suggests feasibility of genotype-directed redox chemotherapeutic intervention targeting NQO1*2 breast cancer, a common missense genotype encoding a functionally impaired NQO1 protein.".
- NAD(P)H_dehydrogenase_(quinone_1) entrezgene "1728".
- NAD(P)H_dehydrogenase_(quinone_1) wikiPageID "14418164".
- NAD(P)H_dehydrogenase_(quinone_1) wikiPageRevisionID "606695623".
- NAD(P)H_dehydrogenase_(quinone_1) hasPhotoCollection NAD(P)H_dehydrogenase_(quinone_1).
- NAD(P)H_dehydrogenase_(quinone_1) requireManualInspection "no".
- NAD(P)H_dehydrogenase_(quinone_1) summaryText "This gene is a member of the NADH dehydrogenase family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia , an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease . Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Recent pharmacological research suggests feasibility of genotype-directed redox chemotherapeutic intervention targeting NQO1*2 breast cancer, a common missense genotype encoding a functionally impaired NQO1 protein.".
- NAD(P)H_dehydrogenase_(quinone_1) updateCitations "yes".
- NAD(P)H_dehydrogenase_(quinone_1) updatePage "yes".
- NAD(P)H_dehydrogenase_(quinone_1) updateProteinBox "yes".
- NAD(P)H_dehydrogenase_(quinone_1) updateSummary "yes".
- NAD(P)H_dehydrogenase_(quinone_1) subject Category:EC_1.6.5.
- NAD(P)H_dehydrogenase_(quinone_1) subject Category:Enzymes_of_known_structure.
- NAD(P)H_dehydrogenase_(quinone_1) subject Category:Flavin_enzymes.
- NAD(P)H_dehydrogenase_(quinone_1) subject Category:NADH-dependent_enzymes.
- NAD(P)H_dehydrogenase_(quinone_1) subject Category:NADPH-dependent_enzymes.
- NAD(P)H_dehydrogenase_(quinone_1) type Biomolecule.
- NAD(P)H_dehydrogenase_(quinone_1) type Protein.
- NAD(P)H_dehydrogenase_(quinone_1) type BiologicalObject.
- NAD(P)H_dehydrogenase_(quinone_1) comment "NAD(P)H dehydrogenase [quinone] 1 is an enzyme that in humans is encoded by the NQO1 gene.This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species.".
- NAD(P)H_dehydrogenase_(quinone_1) label "NAD(P)H dehydrogenase (quinone 1)".
- NAD(P)H_dehydrogenase_(quinone_1) sameAs NQO1.
- NAD(P)H_dehydrogenase_(quinone_1) sameAs m.03d2y1v.
- NAD(P)H_dehydrogenase_(quinone_1) sameAs Q6952186.
- NAD(P)H_dehydrogenase_(quinone_1) sameAs Q6952186.
- NAD(P)H_dehydrogenase_(quinone_1) sameAs NQO1.
- NAD(P)H_dehydrogenase_(quinone_1) sameAs 2157.
- NAD(P)H_dehydrogenase_(quinone_1) sameAs 2388.
- NAD(P)H_dehydrogenase_(quinone_1) sameAs 5103.
- NAD(P)H_dehydrogenase_(quinone_1) wasDerivedFrom NAD(P)H_dehydrogenase_(quinone_1)?oldid=606695623.
- NAD(P)H_dehydrogenase_(quinone_1) isPrimaryTopicOf NAD(P)H_dehydrogenase_(quinone_1).