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- PDE6B abstract "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta is an enzyme that in humans is encoded by the PDE6B gene.Mice homozygous for the rd mutation display hereditary retinal degeneration which has been considered a model for human retinitis pigmentosa. In affected animals, the retinal rod photoreceptor cells begin degenerating at about postnatal day 8, and by 4 weeks no photoreceptors are left. Farber and Lolley (1974, 1976) showed that degeneration is preceded by accumulation of cyclic GMP in the retina and is correlated with deficient activity of the rod photoreceptor cGMP-phosphodiesterase. Bennett et al. (1996) tested the possibility of altering the course of retinal degeneration through subretinal injection of recombinant replication defective adenovirus that contained the murine cDNA for wildtype beta-PDE. Subretinal injection of rd mice was carried out 4 days after birth, before the onset of rd retinal degeneration. Following therapy, beta-PDE transcripts and enzyme activity were detected, and histologic studies revealed that photoreceptor cell death was significantly retarded.[supplied by OMIM]".
- PDE6B entrezgene "5158".
- PDE6B wikiPageExternalLink NBK1417.
- PDE6B wikiPageID "14764791".
- PDE6B wikiPageRevisionID "592758763".
- PDE6B hasPhotoCollection PDE6B.
- PDE6B requireManualInspection "no".
- PDE6B summaryText "345600.0".
- PDE6B updateCitations "yes".
- PDE6B updatePage "yes".
- PDE6B updateProteinBox "yes".
- PDE6B updateSummary "yes".
- PDE6B type Biomolecule.
- PDE6B type Protein.
- PDE6B type BiologicalObject.
- PDE6B comment "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta is an enzyme that in humans is encoded by the PDE6B gene.Mice homozygous for the rd mutation display hereditary retinal degeneration which has been considered a model for human retinitis pigmentosa. In affected animals, the retinal rod photoreceptor cells begin degenerating at about postnatal day 8, and by 4 weeks no photoreceptors are left.".
- PDE6B label "PDE6B".
- PDE6B sameAs m.03gx6_b.
- PDE6B sameAs Q7118791.
- PDE6B sameAs Q7118791.
- PDE6B sameAs PDE6B.
- PDE6B wasDerivedFrom PDE6B?oldid=592758763.
- PDE6B isPrimaryTopicOf PDE6B.