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- Protein-glutamate_methylesterase abstract "In enzymology, a protein-glutamate methylesterase (EC 3.1.1.61) is an enzyme that catalyzes the chemical reactionprotein L-glutamate O5-methyl ester + H2O protein L-glutamate + methanolThus, the two substrates of this enzyme are protein L-glutamate O5-methyl ester and H2O, whereas its two products are protein L-glutamate and methanol.This enzyme is a demethylase, and more specifically it belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is protein-L-glutamate-O5-methyl-ester acylhydrolase. Other names in common use include chemotaxis-specific methylesterase, methyl-accepting chemotaxis protein methyl-esterase, CheB methylesterase, methylesterase CheB, protein methyl-esterase, protein carboxyl methylesterase, PME, protein methylesterase, and protein-L-glutamate-5-O-methyl-ester acylhydrolase. This enzyme participates in 3 metabolic pathways: two-component system - general, bacterial chemotaxis - general, and bacterial chemotaxis - organism-specific. CheB is part of a two-component signal transduction system. These systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. Two-component systems are composed of a sensor histidine kinase (HK) and its cognate response regulator (RR). The HK catalyses its own autophosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, in this case a methyltransferase domain.CheB is involved in chemotaxis. CheB methylesterase is responsible for removing the methyl group from the gamma-glutamyl methyl ester residues in the methyl-accepting chemotaxis proteins (MCP). CheB is regulated through phosphorylation by CheA. The N-terminal region of the protein is similar to that of other regulatory components of sensory transduction systems.".
- Protein-glutamate_methylesterase ecNumber "3.1.1.61".
- Protein-glutamate_methylesterase thumbnail PDB_1a2o_EBI.jpg?width=300.
- Protein-glutamate_methylesterase wikiPageID "14457589".
- Protein-glutamate_methylesterase wikiPageRevisionID "592862908".
- Protein-glutamate_methylesterase caption "structural basis for methylesterase cheb regulation by a phosphorylation-activated domain".
- Protein-glutamate_methylesterase casNumber "93792".
- Protein-glutamate_methylesterase ecNumber "3.1".
- Protein-glutamate_methylesterase goCode "8984".
- Protein-glutamate_methylesterase hasPhotoCollection Protein-glutamate_methylesterase.
- Protein-glutamate_methylesterase interpro "IPR000673".
- Protein-glutamate_methylesterase iubmbEcNumber "3".
- Protein-glutamate_methylesterase name "CheB_methylest".
- Protein-glutamate_methylesterase name "protein-glutamate methylesterase".
- Protein-glutamate_methylesterase pfam "PF01339".
- Protein-glutamate_methylesterase scop "1".
- Protein-glutamate_methylesterase symbol "CheB_methylest".
- Protein-glutamate_methylesterase subject Category:EC_3.1.1.
- Protein-glutamate_methylesterase subject Category:Enzymes_of_known_structure.
- Protein-glutamate_methylesterase subject Category:Protein_domains.
- Protein-glutamate_methylesterase type Abstraction100002137.
- Protein-glutamate_methylesterase type Activator114723079.
- Protein-glutamate_methylesterase type Attribute100024264.
- Protein-glutamate_methylesterase type Catalyst114723628.
- Protein-glutamate_methylesterase type Chemical114806838.
- Protein-glutamate_methylesterase type Compound114818238.
- Protein-glutamate_methylesterase type Environment113934596.
- Protein-glutamate_methylesterase type Enzyme114732946.
- Protein-glutamate_methylesterase type EnzymesOfKnownStructure.
- Protein-glutamate_methylesterase type Macromolecule114944888.
- Protein-glutamate_methylesterase type Material114580897.
- Protein-glutamate_methylesterase type Matter100020827.
- Protein-glutamate_methylesterase type Molecule114682133.
- Protein-glutamate_methylesterase type OrganicCompound114727670.
- Protein-glutamate_methylesterase type Part113809207.
- Protein-glutamate_methylesterase type PhysicalEntity100001930.
- Protein-glutamate_methylesterase type Protein114728724.
- Protein-glutamate_methylesterase type ProteinDomains.
- Protein-glutamate_methylesterase type Relation100031921.
- Protein-glutamate_methylesterase type Situation113927383.
- Protein-glutamate_methylesterase type Sphere114514039.
- Protein-glutamate_methylesterase type State100024720.
- Protein-glutamate_methylesterase type Substance100019613.
- Protein-glutamate_methylesterase type Thing100002452.
- Protein-glutamate_methylesterase type Unit109465459.
- Protein-glutamate_methylesterase type Biomolecule.
- Protein-glutamate_methylesterase type Enzyme.
- Protein-glutamate_methylesterase type BiologicalObject.
- Protein-glutamate_methylesterase comment "In enzymology, a protein-glutamate methylesterase (EC 3.1.1.61) is an enzyme that catalyzes the chemical reactionprotein L-glutamate O5-methyl ester + H2O protein L-glutamate + methanolThus, the two substrates of this enzyme are protein L-glutamate O5-methyl ester and H2O, whereas its two products are protein L-glutamate and methanol.This enzyme is a demethylase, and more specifically it belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds.".
- Protein-glutamate_methylesterase label "Protein-glutamate methylesterase".
- Protein-glutamate_methylesterase sameAs m.03d44dx.
- Protein-glutamate_methylesterase sameAs Q7251415.
- Protein-glutamate_methylesterase sameAs Q7251415.
- Protein-glutamate_methylesterase sameAs Protein-glutamate_methylesterase.
- Protein-glutamate_methylesterase wasDerivedFrom Protein-glutamate_methylesterase?oldid=592862908.
- Protein-glutamate_methylesterase depiction PDB_1a2o_EBI.jpg.
- Protein-glutamate_methylesterase isPrimaryTopicOf Protein-glutamate_methylesterase.
- Protein-glutamate_methylesterase name "protein-glutamate methylesterase".
