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- Squalamine abstract "Squalamine /ˈskweɪləmiːn/ is an aminosterol compound with potent broad spectrum antimicrobial activity discovered in the tissues of the dogfish shark( Squalus acanthias) by a team led by Dr. Michael Zasloff Dr. Zasloff searched the tissues of the dogfish for compounds that might help explain the hardiness of this animal to infection, despite its "primitive" immune system. Using techniques that Zasloff's team had developed to isolate and identify antimicrobial peptides from animal tissues, the team extracted and characterized a novel bile acid like compound containing a polyamine, never before seen in nature. The compound was called "squalamine", based on its source (Squalus acanthias), and its chemical structure ( a sterol linked to a polyamine ). Further analyses of larger quantities of dogfish liver extracts revealed squalamine to be the most abundant member of a larger aminosterol family, comprising at least 12 related compounds. One of these, "MSI-1436" or "Trodusquemine", although structurally similar to squalamine (it carries a spermine rather than a spermidine), and also quite potent as an anti-infective, exhibits a profoundly different pharmacology in vertebrates, causing weight loss and adipose tissue mobilization. Squalamine is sometimes confused with the similar sounding squalene, an unrelated compound also found in shark-liver.".
- Squalamine fdaUniiCode "F8PO54Z4V7".
- Squalamine iupacName "(1S,2S,5S,7R,9R,10R,11S,14R,15R)-N-{3-[(4- aminobutyl)amino]propyl}-9-hydroxy-2,15-dimethyl- 14-[(2R,5R)-6-methyl-5-(sulfooxy)heptan-2- yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5- aminium".
- Squalamine thumbnail Squalamine.png?width=300.
- Squalamine wikiPageID "22213930".
- Squalamine wikiPageRevisionID "598167897".
- Squalamine hasPhotoCollection Squalamine.
- Squalamine imagefile "Squalamine.png".
- Squalamine imagesize "300".
- Squalamine iupacname "-N-{3-[amino]propyl}-9-hydroxy-2,15-dimethyl- 14-[-6-methyl-5-heptan-2- yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5- aminium".
- Squalamine unii "F8PO54Z4V7".
- Squalamine subject Category:Angiogenesis_inhibitors.
- Squalamine subject Category:Polyamines.
- Squalamine subject Category:Steroids.
- Squalamine type Abstraction100002137.
- Squalamine type Chemical114806838.
- Squalamine type Compound114818238.
- Squalamine type Material114580897.
- Squalamine type Matter100020827.
- Squalamine type OrganicCompound114727670.
- Squalamine type Part113809207.
- Squalamine type PhysicalEntity100001930.
- Squalamine type Relation100031921.
- Squalamine type Steroid115057744.
- Squalamine type Steroids.
- Squalamine type Substance100019613.
- Squalamine type ChemicalCompound.
- Squalamine type ChemicalSubstance.
- Squalamine type ChemicalObject.
- Squalamine type Thing.
- Squalamine comment "Squalamine /ˈskweɪləmiːn/ is an aminosterol compound with potent broad spectrum antimicrobial activity discovered in the tissues of the dogfish shark( Squalus acanthias) by a team led by Dr. Michael Zasloff Dr. Zasloff searched the tissues of the dogfish for compounds that might help explain the hardiness of this animal to infection, despite its "primitive" immune system.".
- Squalamine label "Squalamine".
- Squalamine sameAs m.05q5yc4.
- Squalamine sameAs Q15427852.
- Squalamine sameAs Q15427852.
- Squalamine sameAs Squalamine.
- Squalamine wasDerivedFrom Squalamine?oldid=598167897.
- Squalamine depiction Squalamine.png.
- Squalamine isPrimaryTopicOf Squalamine.