Matches in DBpedia 2014 for { ?s ?p 3-β-HSD (or 3-β-hydroxysteroid dehydrogenase/Δ-5-4 isomerase) (EC 1.1.1.145) is an enzyme that catalyzes the synthesis of progesterone from pregnenolone, 17-hydroxyprogesterone from 17-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone in the adrenal gland. It is the only enzyme in the adrenal pathway of corticosteroid synthesis that is not a member of the Cytochrome P450 family. In humans, there are two 3-β-HSD isozymes encoded by the HSD3B1 and HSD3B2 genes.It is also known as delta 5-delta 4-isomerase, which catalyzes the oxidative conversion of delta 5-3 beta- hydroxysteroids to the delta 4-3-keto configuration and is, therefore, essential for the biosynthesis of all classes of hormonal steroids, namely progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens.The 3-beta HSD complex is responsible for the conversion of: pregnenolone to progesterone 17-alpha-pregnenolone to 17-alpha-progesterone dehydroepiandrosterone (DHEA) to androstenedione androstenediol to testosterone↑ ↑. }
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- 3-beta-HSD abstract "3-β-HSD (or 3-β-hydroxysteroid dehydrogenase/Δ-5-4 isomerase) (EC 1.1.1.145) is an enzyme that catalyzes the synthesis of progesterone from pregnenolone, 17-hydroxyprogesterone from 17-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone in the adrenal gland. It is the only enzyme in the adrenal pathway of corticosteroid synthesis that is not a member of the Cytochrome P450 family. In humans, there are two 3-β-HSD isozymes encoded by the HSD3B1 and HSD3B2 genes.It is also known as delta 5-delta 4-isomerase, which catalyzes the oxidative conversion of delta 5-3 beta- hydroxysteroids to the delta 4-3-keto configuration and is, therefore, essential for the biosynthesis of all classes of hormonal steroids, namely progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens.The 3-beta HSD complex is responsible for the conversion of: pregnenolone to progesterone 17-alpha-pregnenolone to 17-alpha-progesterone dehydroepiandrosterone (DHEA) to androstenedione androstenediol to testosterone↑ ↑".