Matches in UGent Biblio for { ?s ?p Aims: Significant aortic regurgitation (AR) may cause left ventricular (LV) dilatation and eventually heart failure. The aim of this study was to quantify LV function in horses with AR by tissue Doppler imaging (TDI) and two-dimensional speckle tracking (2DST). Methods: Echocardiographic examinations (GE Vivid 7 Pro) were performed on ten healthy horses (10±4 years; 509±58 kg) and fourteen horses with significant AR (17±4 years; 497±93 kg). Images were recorded from a right parasternal short-axis (TDI and 2DST) and long-axis view (2DST). By 2DST, global radial (SR) and longitudinal (SL) strain were measured. Regional systolic radial displacement (DRS) by 2DST and velocity (VS) by TDI were measured in the interventricular septum and LV free wall. LV end-diastolic internal diameter (LVIDd) and fractional shortening (FS) were measured from a short-axis M-mode image at chordal level. Results: Seven horses showed moderate AR (LVIDd range 11.0-12.7 cm), seven showed severe AR (LVIDd range 13.3-16.9 cm). FS, SR and SL showed no significant differences. However, SL was significantly correlated with LVIDd in normal horses and horses with moderate AR (r=-0.72, p<0.01) but inversely correlated in horses with severe AR (r=0.82, p<0.05), suggesting LV contractile dysfunction. Regional changes were present in the interventricular septum. Septal DRS and VS were correlated with LVIDd (r=0.667 and -0.778, p<0.001) and were increased in horses with moderate and severe AR compared to normal horses (p<0.05). This indicates increased septal motion in horses with AR both with and without LV dilatation. Conclusions and practical significance: TDI and 2DST allow quantification of altered LV function due to AR. The prognostic value of these measurements remains to be determined.. }
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- aggregation abstract "Aims: Significant aortic regurgitation (AR) may cause left ventricular (LV) dilatation and eventually heart failure. The aim of this study was to quantify LV function in horses with AR by tissue Doppler imaging (TDI) and two-dimensional speckle tracking (2DST). Methods: Echocardiographic examinations (GE Vivid 7 Pro) were performed on ten healthy horses (10±4 years; 509±58 kg) and fourteen horses with significant AR (17±4 years; 497±93 kg). Images were recorded from a right parasternal short-axis (TDI and 2DST) and long-axis view (2DST). By 2DST, global radial (SR) and longitudinal (SL) strain were measured. Regional systolic radial displacement (DRS) by 2DST and velocity (VS) by TDI were measured in the interventricular septum and LV free wall. LV end-diastolic internal diameter (LVIDd) and fractional shortening (FS) were measured from a short-axis M-mode image at chordal level. Results: Seven horses showed moderate AR (LVIDd range 11.0-12.7 cm), seven showed severe AR (LVIDd range 13.3-16.9 cm). FS, SR and SL showed no significant differences. However, SL was significantly correlated with LVIDd in normal horses and horses with moderate AR (r=-0.72, p<0.01) but inversely correlated in horses with severe AR (r=0.82, p<0.05), suggesting LV contractile dysfunction. Regional changes were present in the interventricular septum. Septal DRS and VS were correlated with LVIDd (r=0.667 and -0.778, p<0.001) and were increased in horses with moderate and severe AR compared to normal horses (p<0.05). This indicates increased septal motion in horses with AR both with and without LV dilatation. Conclusions and practical significance: TDI and 2DST allow quantification of altered LV function due to AR. The prognostic value of these measurements remains to be determined.".