Matches in UGent Biblio for { ?s ?p Alzheimer's disease is characterized by the presence of amyloid plaques in the brain, which comprise mainly beta-amyloid peptide and alpha-1-antichymotrypsin. Here, Peter Vandenabeele and Walter Fiers advance the hypothesis that this amyloidogenesis results from an IL-1-/IL-6-mediated acute phase reaction in the brain. They propose possible intracerebral sources of cytokines and acute phase proteins in microglia, astrocytes, neurons and cells of the choroid plexus.. }
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- aggregation abstract "Alzheimer's disease is characterized by the presence of amyloid plaques in the brain, which comprise mainly beta-amyloid peptide and alpha-1-antichymotrypsin. Here, Peter Vandenabeele and Walter Fiers advance the hypothesis that this amyloidogenesis results from an IL-1-/IL-6-mediated acute phase reaction in the brain. They propose possible intracerebral sources of cytokines and acute phase proteins in microglia, astrocytes, neurons and cells of the choroid plexus.".