Matches in UGent Biblio for { ?s ?p Interleukin-2 (IL-2), originally described as a growth factor required for sustained proliferation of T cells in vitro 1,2 is a glycoprotein hormone of known structure3 which appears to be important for the generation of immune responses in vivo 4. As well as T lymphocytes, B lymphocytes5 and large granular lymphocytes with natural killer activity (NK cells)6 can also respond to IL-2. The action of IL-2 seemed to be limited specifically to lymphocytes, however, and the term 'T-lymphocytotrophic hormone' was used7. Here we provide evidence that human monocytes display a substantially increased cytotoxic activity as a direct and rapid response to human recombinant IL-2 but not to human recombinant glycosylated interferon-γ (IFN-γ) or lipopolysac-charide. Our results reveal a previously unknown function of IL-2 and suggest its possible involvement in monocyte-T cell interactions.. }
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- aggregation abstract "Interleukin-2 (IL-2), originally described as a growth factor required for sustained proliferation of T cells in vitro 1,2 is a glycoprotein hormone of known structure3 which appears to be important for the generation of immune responses in vivo 4. As well as T lymphocytes, B lymphocytes5 and large granular lymphocytes with natural killer activity (NK cells)6 can also respond to IL-2. The action of IL-2 seemed to be limited specifically to lymphocytes, however, and the term 'T-lymphocytotrophic hormone' was used7. Here we provide evidence that human monocytes display a substantially increased cytotoxic activity as a direct and rapid response to human recombinant IL-2 but not to human recombinant glycosylated interferon-γ (IFN-γ) or lipopolysac-charide. Our results reveal a previously unknown function of IL-2 and suggest its possible involvement in monocyte-T cell interactions.".