Matches in UGent Biblio for { ?s ?p The alphaherpesvirus US3 kinase is a conserved multifunctional serine/threonine kinase that plays a role in regulating actin dynamics, egress of virus particles from the nucleus and apoptosis. However, the mechanisms used by the US3 protein to exert its functions remain poorly understood. Recently, we identified group A p21-activated kinases as important effectors in the US3-mediated cytoskeletal rearrangements. Here, we investigated if these PAKs are also involved in the other functions of US3. We report that group A PAKs only play a minor role in US3-mediated effects on apoptosis. On the other hand, we identified PAK2 as an important protein in the US3-assisted export of progeny virus from the nucleus, pointing at a possible novel role for PAK2 in nuclear export and suggesting that PAK2 may also be involved in US3-independent processes in the nucleus.. }
Showing items 1 to 1 of
1
with 100 items per page.
- aggregation abstract "The alphaherpesvirus US3 kinase is a conserved multifunctional serine/threonine kinase that plays a role in regulating actin dynamics, egress of virus particles from the nucleus and apoptosis. However, the mechanisms used by the US3 protein to exert its functions remain poorly understood. Recently, we identified group A p21-activated kinases as important effectors in the US3-mediated cytoskeletal rearrangements. Here, we investigated if these PAKs are also involved in the other functions of US3. We report that group A PAKs only play a minor role in US3-mediated effects on apoptosis. On the other hand, we identified PAK2 as an important protein in the US3-assisted export of progeny virus from the nucleus, pointing at a possible novel role for PAK2 in nuclear export and suggesting that PAK2 may also be involved in US3-independent processes in the nucleus.".