Matches in UGent Biblio for { ?s ?p The pharmacokinetics of amoxycillin in pigeons (Columba livia) and the efficacy of amoxycillin treatment in pigeon streptococcosis, were investigated. After intravenous administration of 150mg.kg(-1) amoxycillin, the drug plasma concentration-time profile fitted an open two-compartment model. Amoxycillin was quickly cleared from the circulation with a mean half-life of 66min and showed a distribution volume of 0.9L.kg(-1) The absolute oral bioavailability of amoxycillin was 50.1 %. A 5-day drinking water treatment with amoxycillin (1500mg.L-1, corresponding to 112.0mg.kg(-1).day(-1) during day-light hours) significantly reduced the postinoculation morbidity in pigeons experimentally infected with Streptococcus bovis, compared to untreated infected controls.. }
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- aggregation abstract "The pharmacokinetics of amoxycillin in pigeons (Columba livia) and the efficacy of amoxycillin treatment in pigeon streptococcosis, were investigated. After intravenous administration of 150mg.kg(-1) amoxycillin, the drug plasma concentration-time profile fitted an open two-compartment model. Amoxycillin was quickly cleared from the circulation with a mean half-life of 66min and showed a distribution volume of 0.9L.kg(-1) The absolute oral bioavailability of amoxycillin was 50.1 %. A 5-day drinking water treatment with amoxycillin (1500mg.L-1, corresponding to 112.0mg.kg(-1).day(-1) during day-light hours) significantly reduced the postinoculation morbidity in pigeons experimentally infected with Streptococcus bovis, compared to untreated infected controls.".