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Matches in Ghent University Academic Bibliography for { ?s <http://schema.org/abstract> ?o. }

• 01GRTXTQMW2YJ5PCXW4CWJJH65 abstract "Extrusion-based 3D concrete printing is an emerging technology in the construction field due to the many advantages associated with it as compared to conventional mould casting technology. However, many aspects like durability and long-term service performance are yet to be investigated in detail. The present study focuses on understanding the salt scaling resistance of 3D printed concrete samples. 3D printed concrete samples were prepared with a Portland cement mixture on the one hand and a mixture containing a blend of Portland cement and blast furnace slag on the other hand. The printed samples were subjected to freeze and thaw cycles with a 3% saltwater concentration. It was observed that the 3D printed samples exhibited better resistance against salt scaling compared to the mould cast samples made with the same mixture. The pore structure of the 3D printed samples was characterized by mercury intrusion porosimetry. It was observed that the presence of a higher amount of interconnected and coarser pores at the interlayer region of the 3D printed samples, acting like pockets of air voids, facilitates the release of ice crystallization pressure during the freezing phase. The study gives insights into the durability characteristics and feasibility of using 3D printed concrete elements exposed to aggressive environmental conditions.".
• 01GRTY86T4TWRWWM3CVWCETCDP abstract "Introduction Trimeric intracellular potassium channels TRIC-A and -B are endoplasmic reticulum (ER) integral membrane proteins, involved in the regulation of calcium release mediated by ryanodine (RyRs) and inositol 1,4,5-trisphosphate (IP(3)Rs) receptors, respectively. While TRIC-A is mainly expressed in excitable cells, TRIC-B is ubiquitously distributed at moderate level. TRIC-B deficiency causes a dysregulation of calcium flux from the ER, which impacts on multiple collagen specific chaperones and modifying enzymatic activity, leading to a rare form of osteogenesis imperfecta (OI Type XIV). The relevance of TRIC-B on cell homeostasis and the molecular mechanism behind the disease are still unknown. Results In this study, we exploited zebrafish to elucidate the role of TRIC-B in skeletal tissue. We demonstrated, for the first time, that tmem38a and tmem38b genes encoding Tric-a and -b, respectively are expressed at early developmental stages in zebrafish, but only the latter has a maternal expression. Two zebrafish mutants for tmem38b were generated by CRISPR/Cas9, one carrying an out of frame mutation introducing a premature stop codon (tmem38b(-/-)) and one with an in frame deletion that removes the highly conserved KEV domain (tmem38b(Delta 120-7/Delta 120-7)). In both models collagen type I is under-modified and partially intracellularly retained in the endoplasmic reticulum, as described in individuals affected by OI type XIV. Tmem38b(-/-) showed a mild skeletal phenotype at the late larval and juvenile stages of development whereas tmem38b(Delta 120-7/Delta 120-7) bone outcome was limited to a reduced vertebral length at 21 dpf. A caudal fin regeneration study pointed towards impaired activity of osteoblasts and osteoclasts associated with mineralization impairment. Discussion Our data support the requirement of Tric-b during early development and for bone cell differentiation".
• 01GRTYAA0DBXJEX0NN76SY0BTF abstract "The evolution to Industry 4.0 is creating the impetus for the manufacturing industry to increase productivity through smart management and stabilization of resources, capacity and utilisation. Increased plant availability, extended service life of resources as well as optimised product and process quality require intelligent maintenance strategies. The conventional reactive maintenance (run-to-failure) causes unexpected production stoppages, and preventive maintenance at times leads to waste of working hours and material due to the premature replacement of machine components. A smart Predictive Maintenance (PdM) strategy equipped with fault detection and prediction based on acquired, processed and analysed data can result in an accurate estimation of the Remaining Useful Life (RUL) of machine components and thus trigger appropriate maintenance action plans. Data acquisition, processing, analysis and rule-based decision supporting require the development, application and combination of various Industrial Internet of Things (IIoT) devices, models and methods in an integrated manner. Through transparent development and integrated harmonisation of all models, methods and technologies, fault detections and respective RUL estimations of machine components become more accurate and reliable. This leads to an increasing acceptance of employees towards software-based recommendations, in particular maintenance instructions for operators and proposals for an optimised development of the next generation of production systems and equipment. Within the scope of the EU-funded project Z-BRE4K, this paper proposes an IIoT architecture that presents models, methods and technologies in an integrated manner and highlights the data and information flow between them. The architecture including the infrastructure has been applied in three pilot cases with the industrial end users PHILIPS, GESTAMP and CDS to demonstrate the compatibility of the architecture to different industries with various production systems and diverse conditions, requirements and needs. Based on the adaption of the generic architecture for the pilot cases, the models, methods and technologies were developed efficiently and continuously improved and validated. The proposed architecture is intended to be applicable across industries to facilitate the transformation from reactive or preventive to PdM and thereby improve the competitiveness of manufacturing companies.".
• 01GRTYD8HDQZ4YDMES8MF6QG7Q abstract "Visual analytics is arguably the most important step in getting acquainted with your data. This is especially the case for time series, as this data type is hard to describe and cannot be fully understood when using for example summary statistics. To realize effective time series visualization, four requirements have to be met; a tool should be (1) interactive, (2) scalable to millions of data points, (3) integrable in conventional data science environments, and (4) highly configurable. We observe that open source Python visualization toolkits empower data scientists in most visual analytics tasks, but lack the combination of scalability and interactivity to realize effective time series visualization. As a means to facilitate these requirements, we created Plotly-Resampler, an open source Python library. Plotly-Resampler is an add-on for Plotly's Python bindings, enhancing line chart scalability on top of an interactive toolkit by aggregating the underlying data depending on the current graph view. Plotly-Resampler is built to be snappy, as the reactivity of a tool qualitatively affects how analysts visually explore and analyze data. A benchmark task highlights how our toolkit scales better than alternatives in terms of number of samples and time series. Additionally, Plotly-Resampler's flexible data aggregation functionality paves the path towards researching novel aggregation techniques. Plotly-Resampler's integrability, together with its configurability, convenience, and high scalability, allows to effectively analyze high-frequency data in your day-to-day Python environment.".
• 01GRTYQS69X78N0JQEVG7XVXPN abstract "Haemal lordosis, a frequent skeletal deformity in teleost fish, has long been correlated with increased mechanical loads induced by swimming activity. In the present study, we examine whether juvenile zebrafish can recover from haemal lordosis and explore the musculoskeletal mechanisms involved. Juveniles were subjected to a swimming challenge test (SCT) that induced severe haemal lordosis in 49% of the animals and then immediately transferred them to 0.0 total body lengths (TL) per second of water velocity for a week. The recovery from lordosis was examined by means of whole mount staining, histology and gene expression analysis. Results demonstrate that 80% of the lordotic zebrafish are capable of internal and external recovery within a week after the SCT. Recovered individuals presented normal shape of the vertebral centra, maintaining though distorted internal tissue organization. Through the transcriptomic analysis of the affected haemal regions, several processes related to chromosome organization, DNA replication, circadian clock and transcription regulation were enriched within genes significantly regulated behind this musculoskeletal recovery procedure. Genes especially involved in adipogenesis, bone remodeling and muscular regeneration were regulated. A remodeling tissue-repair hypothesis behind haemal lordosis recovery is raised. Limitations and future possibilities for zebrafish as a model organism to clarify mechanically driven musculoskeletal changes are discussed.".
• 01GRTYYKP9X5TXR3NHGRSETSK6 abstract "Intermuscular bones (IBs) are mineralized spicules, present in the myosepta of many, but not all, teleost species. IBs are often small and sharp, and they consequently limit how the fish can be processed; the IBs may cause injury or trauma if lodged in consumers' throats or mouths, and therefore affect the appeal of the fish to many consumers. The development of IBs in teleosts is still not fully understood and the molecular basis of IB development remains to be established. Here, the characteristics of IB tissue are evaluated based on single-cell transcriptomics in wild-type zebrafish. The analysis defined 18 distinct cell types. Differentiation trajectories showed that IBs are derived from tendons and that a core tendon-osteoblast cell lineage is related to IB formation. In particular, the functions of 10 candidate genes were evaluated via CRISPR-Cas9 mutants. Among those, runx2b(-/-) mutants completely lost IBs, while swimming performance, growth and bone mineral density were not significantly different from runx2b(+/+) zebrafish. Comparative single-cell RNA sequencing (scRNA-seq) analysis in runx2b(-/-) and runx2b(+/+) zebrafish revealed the role of osteoblasts in IB formation. In addition, differentially expressed genes were enriched in the transforming growth factor beta/bone morphogenetic protein (TGF-beta/BMP) pathway after runx2b deletion. This study provides evidence for the crucial role of runx2b regulation in IB formation. Genetic breeding can target runx2b regulation and generate strains of commercial fish species without IBs, which can improve the safe consumption and economic value of many farmed fish species.".
• 01GRTZ22TC199H4VA0HAQ27MW7 abstract "Provides an overview of core concepts and technological foundations for continuous processing of Streaming Linked Data Presents a list of real-world examples as well as exercises that will guide future researchers and practitioners Introduces RSP4J, a novel open-source project that gathers community efforts".
• 01GRTZE6XQ125XQXZKHWHP4210 abstract "Oryzias latipes is increasingly used as a model in biomedical skeletal research. The standard approach is to generate genetic variants with particular skeletal phenotypes which resemble skeletal diseases in humans. The proper diagnosis of skeletal variation is key for this type of research. However, even laboratory rearing conditions can alter skeletal phenotypes. The subject of this study is the link between skeletal phenotypes and rearing conditions. Thus, wildtype medaka were reared from hatching to an early juvenile stage at low (LD: 5 individuals/L), medium (MD: 15 individuals/L), and high (HD: 45 individuals/L) densities. The objectives of the study are: (I) provide a comprehensive overview of the postcranial skeletal elements in medaka; (II) evaluate the effects of rearing density on specific meristic counts and on the variability in type and incidence of skeletal anomalies; (III) define the best laboratory settings to obtain a skeletal reference for a sound evaluation of future experimental conditions; (IV) contribute to elucidating the structural and cellular changes related to the onset of skeletal anomalies. The results from this study reveal that rearing densities greater than 5 medaka/L reduce the animals' growth. This reduction is related to decreased mineralization of dermal (fin rays) and perichondral (fin supporting elements) bone. Furthermore, high density increases anomalies affecting the caudal fin endoskeleton and dermal rays, and the preural vertebral centra. A series of static observations on Alizarin red S whole mount-stained preural fusions provide insights into the etiology of centra fusion. The fusion of preural centra involves the ectopic formation of bony bridges over the intact intervertebral ligament. An apparent consequence is the degradation of the intervertebral ligaments and the remodeling and reshaping of the fused vertebral centra into a biconoid-shaped centrum. From this study it can be concluded that it is paramount to take into account the rearing conditions, natural variability, skeletal phenotypic plasticity, and the genetic background along with species-specific peculiarities when screening for skeletal phenotypes of mutant or wildtype medaka.".
• 01GRV1TQ2B4KGK4SSP7CGKNN88 abstract "To assure high safety levels and functionality over the lifespan of concrete structures (50-100 years), it is important to understand the material's behavior. As widely known, concrete changes its performance over time typically leading to enhanced material properties if deterioration mechanisms are neglected (e.g. Alkali-Silica Reaction). This contribution considers merely the former aspect of enhanced material properties. The source of the so-called concrete aging is the ongoing hydration of the cement paste, which depends on the environmental conditions and the mix design. Consequently, it is crucial to understand the evolution of concrete properties as a function of the reaction degree. In this contribution, the previous established age-dependent lattice discrete particle model developed by Wan et al. for UHPC is applied to normal and high strength concretes. This model consists of a multi-physics model solving the relevant heat and moisture transport mechanisms as well as the chemical reactions and a discrete particle model which simulates concrete at the meso-scale. These two components are coupled by a set of aging functions, mapping the reaction degree to the meso-scale parameters. The framework is applied to an extensive data-set, including test data of concretes with various compositions and ages between 1 day and 155 days. The experimental data include calorimetric and shrinkage tests, measurements of internal humidity and temperature as well as different kinds of mechanical tests. The framework captures the experimental data well with minor changes in the aging laws. Furthermore, the results indicate a strong dependence of the aging parameters on the cement type.".
• 01GRV1ZEPWF589NHFD0TBGZ53H abstract "This study investigates moisture uptake and diffusion mechanisms in thermoset particle-filled composites for anchor applications. Two epoxy-based with low inorganic filler content and one vinyl ester-based with high inorganic filler content were studied. Material characterization revealed particle size distribution, particle density, the occurrence of pores, and filler composition. Moisture diffusion was monitored at different temperatures, different relative humidities, and in water immersion for up to 540 days. Based on these results a sorption isotherm, temperature dependencies, and diffusion paths could be determined. A phenomenological hybridisotherm, consisting of a combination of Henry's linear isotherm and Type III isotherm, was applied to describe the effect of different fillers on equilibrium moisture uptake. Fickian diffusion was observed for all composites with temperature-dependent Arrhenius relation. These observations allowed us to suggest three diffusion paths: through the polymer matrix, on the matrix-filler interfaces, and through matrix and fillers simultaneously.".
• 01GRV22NN3HFPRDF27MC8DWFBQ abstract "Thermoset polymers are widely used in the civil engineering field, especially as adhesives, coatings, and matrices for composite materials. During the in-situ application of these materials, thermal activation is typically not possible, resulting in an undefined curing state of the system, which depends on the reaction kinetics and ambient conditions. These resins can also react at low temperatures; however, a certain amount of time is needed to reach a fully cured state. This characteristic complicates the assessment of the mechanical properties and the prediction of long-term behavior. In this work, primarily the loading rate effect on strength is analyzed for different curing states, which are derived from relevant in-situ conditions while also the effect of stiffness is discussed. The degrees of cure have been assessed by means of DSC measurements after submitting the samples to specific curing and post-curing protocols. Two products, one epoxy-based and one vinyl ester-based, have been studied. The tensile strength of these materials was characterized at various loading rates, monitoring the strain using digital image correlation (DIC). The results reveal that the loading rate effect on strength and stiffness strongly depends on the polymer's curing degree. Finally, simplified models able to describe the dependencies between the degree of cure of the thermosets and the rate effects on strength and stiffness are proposed as an essential element for realistic numerical simulations of incompletely cured thermosets in real world applications.".
• 01GRV26WV4903VYEP7X1ECKCDD abstract "Employing CaO-based expansive agent (CaO-based EA) and superabsorbent polymer (SAP) in ultra-high per-formance concrete (UHPC) is a effective strategy to mitigate the shrinkage. The cracking identification can help to verify whether the cracking risk can be reduced. In this paper, the shrinkage cracking behavior of ultra-high strength mortar (UHSM, UHPC matrix) with different dosage of CaO-based EA and SAP was observed based on the temperature stress testing machine (TSTM) tests. The coupling mechanism of EA and SAP was investigated by comparing the cracking process to hydration progress, hydration product and internal water distribution at each stage. Furthermore, the creep and elastic modulus were also calculated to clarify the cracking risk development of UHSM with EA and SAP. Unlike ordinary concrete, "Time-zero" of shrinkage should also be redefined in UHSM with EA and SAP due to the change in early age deformation rate. Although the addition of EA and SAP can significantly increase the expansive deformation of UHSM at early age, cracking still occurs due to the post-peak shrinkage.".
• 01GRV2W7YJEF7XHH620BN88G9R abstract "With the support of the Olivia Hendrickx Research Fund, the ‘Team EARly DRug development in Paediatric oncology (TEARDRoP)’ consortium was founded. As the name indicates, this consortium was set up to support the translation of new research findings in the field of paediatric oncology to new therapeutic options, making science find its way to children in need of new and better treatments. In specific, the consortium will help bridge the gap between basic and clinical research through stimulating close collaborations and supporting biobanking efforts. Therefor I write and bring in to (clinical) practice practical flows for the biobanking of human body material for (inter)national academic clinical studies and general research, as well as support the set-up of a national pediatric-specific biobank collection. The access to patient material via this biobanking effort is crucial for the translation of (basic) research findings to the clinic, and is of utmost importance for the development and selection of the best fit treatment for each patient, the focus of personalized medicine. Thanks to the support of the Olivia Fund, I was appointed as coordinator of this consortium, under the direct supervision of paediatric oncologist Prof. Dr. Bram De Wilde (UZ Gent, CRIG), Prof. Dr. Catherine Van Der Straeten (HIRUZ UZ Gent), and Prof. Dr. Tim Lammens (UGent, CRIG). To ensure all (Belgian) patients benefit from the initiative, the TEARDRoP consortium has a close partnership with the ‘Belgian Society of Pediatric Haematology Oncology (BSPHO)’, an organization that has been supporting academic research into children’s cancer for years.".
• 01GRV39TYPKRFJ40N9G8EQ67KC abstract "Seventy-five blocks of low-moisture part-skim mozzarella cheese were procured from an industrial cheese plant, and the relationships between the physicochemical and functional properties were evaluated during refrigerated storage. In total, cheeses were obtained from 1 cheese vat on 7 different production dates, at 2 to 4 monthly intervals, over a 1.5-yr period; all cheeses were made using a standard recipe. The cheeses were held at 4°C for 0, 1, 2, 4, 8, 16, or 32 d and assayed for composition, primary proteolysis, serum distribution, texture profile analysis, heat-induced changes in viscoelastic behavior, cheese extensibility, and melt characteristics. The results demonstrated a substantial increase in serum uptake by the calcium-phosphate para-casein matrix between 1 and 16 d of storage with a concomitant improvement in the functional performance of the cheese. Extending the storage time to 32 d resulted in further changes in the functional quality, concurrent with ongoing increases in protein hydration and primary proteolysis. Differences in the measured characteristics between the cheeses obtained on different sampling occasions were evident. Principal component analysis separated the cheeses based on their variance in functional performance, which was found to be correlated mainly with the calcium content of the cheese. The results indicate that the manufacturing process should be tightly controlled to minimize variation in calcium content and enhance the quality consistency of the cheese.".
• 01GRV3J039J5PGR2PV4XT4935A abstract "With the support of the Olivia Hendrickx Research Fund, the ‘Team EARly DRug development in Paediatric oncology (TEARDRoP)’ consortium was founded to support the translation of new research findings in the field of pediatric oncology to new therapeutic options, making science find its way to children in need of new and better treatments. In specific, the consortium aims to support biobanking efforts through a bottom-up approach by: (i) bringing in to (clinical) practice practical flows for the biobanking of human body material for (inter)national academic clinical studies and general research, embedded into routine in order to help healthcare workers, (ii) set-up a national pediatric oncological-specific biobank collection as these are rare and precious materials The longitudinal collection and access to patient material via this biobanking effort is crucial for the translation of (basic) research findings to the clinic, and is of utmost importance for the development and selection of the best fit treatment for each patient, the focus of personalized medicine. To ensure all (Belgian) patients benefit from the initiative, the TEARDRoP consortium has a close partnership with the ‘Belgian Society of Pediatric Haematology Oncology (BSPHO)’, an organization that has been supporting academic research into children’s cancer for years. ".
• 01GRV3W1RMBZWCD1QHAAQ5DANZ abstract "BACKGROUND: Generic self-report measures do not reflect the complexity of a person's pain -related behavior. Since variations in a person's fear of movement and avoidance behavior may arise from contextual and motivational factors, a person-centered evaluation is required-addressing the cognitions, emotions, motivation, and actual behavior of the person.CLINICAL QUESTION: Most musculoskeletal rehabilitation clinicians will recognize that different people with chronic pain have very different patterns of fear and avoidance behavior. However, an important remaining question for clinicians is "How can I identify and reconcile discrepancies in fear of movement and avoidance behavior observed in the same person, and adapt my management accordingly?"KEY RESULTS: We frame a clinical case of a patient with persistent low back pain to illustrate the key pieces of information that clinicians may consider in a person-centered evaluation (ie, patient interview, self-report measures, and behavioral assessment) when working with patients to manage fear of movement and avoidance behavior.CLINICAL APPLICATION: Understanding the discrepancies in a person's fear of movement and avoidance behavior is essential for musculoskeletal rehabilitation clinicians, as they work in partnership with patients to guide tailored approaches to changing behaviors.".
• 01GRV48PVYZHRFFS94R2S56XT8 abstract "Het vertrekpunt van het artikel is het vraagstuk van het geweld binnen de context van een school. Centraal staat de idee dat er een spanning bestaat tussen ervaring en een taal voor die ervaring, een idee die naar voor wordt gebracht door zowel Freud als de Russische psycholoog Vygotsky. Het geweld wordt gehoord als de uitdrukking van een gemiste ontmoeting tussen ervaring en taal. Aan de hand van een aantal psychoanalytische concepten wordt deze stelling gedifferentieerd en telkens aangevuld met een klinisch fragment.".
• 01GRV4PF6Q6QPNBE3FDWZRVEW7 abstract "Although cities are highly dependent on the constant supply of food, urbanisation processes usually herald the end of local food production. Current urbanisation processes go hand in hand with a global food regime, actively contributing to the substitution of local food production. Numerous social and environmental excesses of the global food regime are challenging the existing urbanisation model in which agricultural rationales are absent. The starting point of this research is that a different, more sustainable food system also requires a different urbanisation model (and vice versa). This PhD examines how urbanisation processes could support local, agroecological food production. The search for such an “agroecological urbanism” departs at farm level, embedded in action research in an existing farming community in Flanders. From this, the PhD derives its thematic focus on one of the central issues in agroecological agriculture: how to compensate for a loss of soil fertility within the ecological boundaries of agroecosystems? The PhD explores what it means to understand agroecological soil fertility reproduction not as separate from urbanisation (as an individual responsibility of the farmer) but rather as an object of collective, urban organisation (the “urbanisation” of soil fertility reproduction). This is elaborated empirically in two ways. A critical systematisation of agroecological soil fertility reproduction practices demonstrates the disabling nature of current urbanisation processes and identifies pathways for an urbanism that does cater for these practices. An in-depth analysis of public landownership and public land transactions then explores the need and potential of public land management as part of an agroecological urbanism. The research results in a repoliticisation of soil fertility reproduction as both an agricultural and an urban issue, the elaboration of soil care as part of an agroecological urbanism and (re)new(d) attention to the crucial importance of land policy for enabling agroecological soil care.".
• 01GRV4PF6Q6QPNBE3FDWZRVEW7 abstract "Hoewel steden erg afhankelijk zijn van de constante aanvoer van voedsel, luiden verstedelijkingsprocessen doorgaans het einde in van lokale voedselproductie. Verstedelijking gaat vandaag hand in hand met een mondiaal voedselregime, waardoor lokale voedselproductie perfect vervangbaar lijkt. De talrijke sociale en ecologische uitwassen van het mondiaal voedselregime plaatsen stilaan echter grote vraagtekens bij een verstedelijkingsmodel waarin landbouwlogica’s geen plaats hebben. Het vertrekpunt van dit onderzoek is dat een ander, meer duurzaam voedselsysteem dus ook een ander verstedelijkingsmodel vereist (en vice versa). Dit doctoraatsonderzoek bestudeert hoe verstedelijkingsprocessen lokale, agro-ecologische voedselproductie zouden kunnen ondersteunen. De zoektocht naar zo’n “agro-ecologische stedenbouw” vertrekt bij de boer zelf, via actieonderzoek in een bestaande boerengemeenschap in Vlaanderen. Hieraan ontleent het doctoraat zijn thematische focus op één van de centrale vraagstukken in de agro-ecologische landbouw: hoe kan een verlies aan bodemvruchtbaarheid gecompenseerd worden binnen de ecologische grenzen van agro-ecosystemen? Het doctoraat verkent wat het betekent om de agro-ecologische reproductie van bodemvruchtbaarheid niet los van verstedelijking te zien (als een individuele verantwoordelijkheid van de boer) maar net als voorwerp van collectieve, stedelijke organisatie (de ‘verstedelijking’ van bodemvruchtbaarheidsreproductie). Dit wordt op twee fronten empirisch uitgewerkt. Een kritische systematisering van agro-ecologische bodemvruchtbaarheidsreproductiepraktijken laat zien hoe huidige verstedelijkingsprocessen dit tegenwerken en benoemt pistes voor een stedenbouw die deze praktijken wel verzorgt. Een diepgaande analyse van publiek grondbezit en publieke grondtransacties verkent vervolgens de nood en het potentieel van public land management als onderdeel van een agro-ecologische stedenbouw. Het onderzoek resulteert in een herpolitisering van bodemvruchtbaarheidsreproductie als agrarisch en als stedelijk vraagstuk, de uitwerking van bodemzorg als onderdeel van een agro-ecologische stedenbouw en (her)nieuw(d)e aandacht voor het cruciale belang van grondbeleid voor bodemzorg.".
• 01GRV7BDS6QRCA7DSJTDBXP9WQ abstract "Discussions on the nature and evolution of pre-modern European polities are as old as history itself as an academic discipline. When the scholarly enquiry into the past found a home in universities, first in the German-speaking world with the efflorescence of Historismus in the early nineteenth century and soon after in other parts of the world, historians were first and foremost preoccupied with tracing the genealogies of their own political projects, that is, the nineteenth-century states. The first question is how to conceptualise the dynastic union of two or more territories as a political and social project. For this, this chapter focuses on classic essay of John H. Elliott on composite unions in early modern Europe which was published in 1992 in Past & Present. The best approach to test whether processes of dynastic unification and disintegration among princely dynasties and regional elites were structurally identical or not is to compare whether both milieus saw the same trend towards concentration.".
• 01GRV7ZHT3MGG2F99QY5A8B5JK abstract "This study aims to analyse how Atticist lexicographers used ancient sources to problematize their lack of sensitivity to literary contexts. This article focuses on comic passages that are interpreted according to the prescriptive outlook of Atticist lexicographers. I will show how lexicographers' notes on linguistic correctness betray a general indifference towards the stylistic registers and complex variety of the language of comedy. Two case studies will be investigated: (a) the backdating of koine words and (b) the misinterpretation of comic corrections. The analysis of these two cases shows that lexicographers very often interpreted comic attestations as evidence of regular Greek expressions if this reading served the purpose of censoring or supporting a specific usage, regardless of whether or not the comedians were using a word metaphorically or in a jocular way.".
• 01GRV83HZHN2WS2VERWDWN0VQ0 abstract "Additive manufacturing is a perfect tool to manufacture topologically optimized elements. This is mostly done by 3D printing the contour of the desired element. As these printed constructions are hollow, their loadbearing capacity is limited. The use of a proper infill material can help to get rid of this shortcoming by properly integrating a conventional reinforcement system. Self-compacting concrete (SCC) seems an excellent material choice as it can flow into the irregular printed spaces. Not only the high flow properties are important, but the adhesion between the two types of concrete is of interest too. A good bond is needed to prevent delamination and assure a proper force transfer between the two materials. In this study, the bond strength between 3D printed and self-compacting concrete was tested. Linear 3D printed elements were cured at different conditions (dry and submerged in water) for different time periods (2, 6, 13 and 28 days) before casting SCC adjacent to it. After 28 days of curing of the SCC, cores were drilled out of the composite specimens and a direct tensile test was performed. Results showed that the bond strength between the two materials is neither dependent on the curing time of the printed material nor on the curing condition. However, the fracture plane does seem to be influenced by these factors. Specimens cured under water or specimens cured for a limited period tend to fail more at the interface between the two materials, while the ones cure".
• 01GRV85KN53R4JETCK4B59YS86 abstract "This article examines the case of Paul Lasker, Else Lasker-Schüler’s son, and his brief and ill-fated stint at the Odenwaldschule in the early 1900s. It discusses the school’s principles of holistic education and focus on students’ individual talents, situated in the wider Lebensreform movement. However, Paul faced difficulties and was eventually expelled, with the director citing cognitive and behavioral issues. The article analyzes this incident in light of ableist assumptions prevalent at the time, and questions if the school’s ideals of self-optimization and adaptation could accommodate neurodiverse pupils like Paul. The central paradox at stake can be paraphrased as follows: while the reform school’s director aimed to advocate against standardization and Prügelpädagogik, he relied not only on ableist and eugenicist conceptions (most virulently: regarding Paul’s stuttering and presumed low iq), but also on more ambiguously benign notions like students’ potential for self-efficacy, self-fashioning and selfimprovement in order to marginalize those who did not fit the norms of their era.".
• 01GRV8E9P19E1G84YDTKFP9K69 abstract "Aiming at obtaining good shape stability after extrusion, accelerators are used in extrusion-based 3D concrete printing. Instead of injecting a liquid accelerator into fresh concrete, limestone slurry is proposed as a carrier for the dry accelerator in this study. As such, two pumpable mixtures (a Portland cement-based mixture and a limestone powder-based mixture) and a combination of these two mixtures (a combined mixture) were prepared. The flow behaviors and structural build-up were investigated, respectively.".
• 01GRV96YAR69MNWMVB30K3MMR0 abstract "3D concrete printing (3DCP) is currently being explored both in academia and prac-tice and ensures a fast, economic, safe and formwork-free construction process. Although the elimination of formwork is one of the biggest advantages, it also removes the protection be-tween the curing concrete and the surrounding environment. As a consequence of the latter, cracking resulting from shrinkage can be more pronounced. Additionally, the effect of the layered fabrication process and the absence of compaction could increase the porosity and the occurrence of weakly bonded interfaces. The combination of these three phenomena might affect the durability of 3DCP elements, as these interfaces form ideal ingress paths for chemical substances. In order to improve the long-term behavior, this study aimed to comprehend the correlation between different print process parameters and the resistance against carbonation. Therefore, multi-layered elements were fabricated with two different print techniques (2D and 3D) and two interlayer time gaps (0 and 30 min). To enable a complete comparison between both fabrication processes also conventional cast elements were considered. In general, a more pronounced CO2 penetration could be observed in case of the printed elements, related to the higher porosity. Additionally, enlarged time gaps tend to be detrimental for the long-term be-havior, however, this effect could be counteracted the 3D-print technique. The higher pump pressure improves the bonding between subsequent layers and the general long-term behavior.".
• 01GRV9ERHQ5T535PYR2SXBKF2G abstract "Smartphone-based WiFi ranging using fine time measurement (FTM) is severely impacted by Non-line-of-sight (NLoS) environments, which causes significant positioning errors. To address this problem, we propose a novel WiFi FTM positioning (WFP) approach based on the geomagnetism and enhanced genetic algorithm (EGA), which can simultaneously execute WiFi localization and ranging compensation. Based on the distribution of the ranging error in NLoS environments, a semiparametric error model-based ranging compensation method is proposed. To construct the EGA searching model, geomagnetism-based positioning is adopted and fed to the EGA together with the measured WiFi ranging data and the ranging compensation method. During online localization, the EGA model dynamically compensates for the erroneous ranging data until it finds the optimal position. Experimental results show that the ranging and localization accuracy of this EGA-based WFP are 1.33 m and 1.64 m, being an improvement of 30.7% and 56.5% compared to the uncompensated ranging data and the trilateration algorithm using the weighted least square (WLS) method, respectively.".
• 01GRV9KPJKYMD2H5R9JDZBF7WA abstract "Adhesive anchors are fastening solutions widely used in new and old structures for their strengthening and rehabilitation. Their flexible nature and ease of use facilitate the installation and attachment of new load bearing components to old concrete members. Nowadays, sustainability represents an important requirement in the design and rehabilitation of structures and their connections. This requires understanding their longterm behavior, since they are affected by sustained loads that, due to the gradual increase in deformations, ultimately lead to failure. Despite their advantages due to different influencing factors such as concrete aging, nonlinear viscosity, and post-curing of the adhesive and anchor geometry, the load-bearing behavior of adhesive anchors under sustained loading is still not very well understood. This paper presents the summary of the results of an extensive experimental test campaign, in particular isolating the potential effect of the embedment depth on tertiary creep rupture of a vinyl-ester based commercially available anchor system. This was achieved by means of an experimental campaign consisting of a series of tensile tests in a confined configuration. Each configuration consists of a set of short-term pull-out tests to determine the ultimate capacity followed by sustained load tests at various load levels. The ultimate load is used to define the load levels for long-term tests which are applied to a limited number of specimens. The time to failure is recorded for every sustained-load test and the so called time-to-failure curves are constructed by fitting the resulting data points based on different regression models. Finally, the different models are analyzed according to the long-term behavior prediction of the adhesive anchors.".
• 01GRVA3HYK94F21H03CE3A1CWM abstract "Smartphone-based WiFi ranging positioning based on fine time measurement (FTM) always collapses in real-life scenarios. In this work, a novel map-aided particle filter (PF)-based WiFi FTM fingerprinting approach is proposed to address the poor performance of the WiFi FTM ranging positioning. Different from manually collecting fingerprints, this approach utilizes the theoretical received signal strength and geometric distances between the access points and reference points as the fingerprints, which means less labour-intensive work. For accurate WiFi position estimation, a map-aided PF is designed to find the optimal position. Extensive experiments are carried out in the non-line-of-sight (NLoS) and mixed line-of-sight/non-line-of-sight (LoS/NLoS) environments, and the testing results show that the accuracy and stability of FTM fingerprinting are improved by using the mixed RSS and ranging data fingerprints. The minimal mean location errors (MEs) of the PF-based WiFi FTM fingerprinting in NLoS and mixed LoS/NLoS conditions are 1.70 m and 1.85 m, respectively. Compared to the classic weighted least square method, the MEs are reduced by 54.91% and 45.43%, respectively. The testing results demonstrate that the PF-based FTM fingerprinting is an effective approach that provides satisfactory localization results in real-life indoor environments.".
• 01GRVANV5SQ19W5NN06V4D3HNY abstract "WiFi-based indoor localization using the fine time measurement (FTM) protocol has become a popular technique. However, in harsh Non-Line-of-Sight (NLoS) environments, WiFi FTM positioning (WFP) suffers from poor performance. In this letter, a novel WiFi FTM localization method with the assistance of geomagnetic positioning (GP) is proposed. To ensure the accuracy of GP, an enhanced mind evolutionary algorithm (EMEA) is designed. A fine-grained WiFi position estimation method using the overlapping searching area (OSA) and the coincident points selection strategy is proposed. Experimental results show that the EMEA-based GP improves the localization performance of WFP in NLOS environments, the mean localization error (ME) and root-mean-square error (RMSE) of the GP-aided WFP are 1.82 m and 2.08 m, respectively. Compared with the classic WFP using the weighted least square (WLS) method, the ME and RMSE are reduced by 51.7% and 52.4%, respectively.".
• 01GRVAV0Z48624MDQ6AXM1VR7C abstract "Radio frequency identification (RFID) localization technology has attracted great attention in stocktaking in warehouses. In this paper, we investigate drone-based RFID localization for fast and accurate inventory management. Considering the drone trajectory errors, we propose a robust RFID lateral localization method based on the unwrapped phase, in which a temporal convolutional network (TCN) with non-causal convolutions is designed for the phase unwrapping. The tagged assets are localized via the nonlinear optimization upon the unwrapped phases. The experiment results in a logistic warehouse show that the proposed algorithm achieves RFID localization with 0.17-metermean absolute errors and 0.4- meter 90-th percentile errors, respectively.".
• 01GRVBBZAQBWC9PWDJ6Q2MDFP2 abstract "Stickler syndrome is a connective tissue disorder characterized by ocular, skeletal, orofacial and auditory manifestations. Its main symptoms are high myopia, retinal detachment, joint hypermobility, early osteoarthritis, cleft palate, midfacial hypoplasia, micrognathia and hearing loss. Large phenotypical variability is apparent and partly explained by the underlying genetic heterogeneity, including collagen genes (COL2A1, COL11A1, COL11A2, COL9A1, COL9A2, COL9A3) and non-collagen genes (BMP4, LRP2, LOXL3). The most frequent type of Stickler syndrome (COL2A1) is characterized by a rather mild high-frequency sensorineural hearing loss in about half of the patients. COL11A1- and COL11A2-related Stickler syndrome results in more frequent hearing loss, being moderate and involving all frequencies. Hearing loss in the rarer types of Stickler syndrome depends on the gene expression in the cochlea, with moderate to severe downsloping hearing loss for Stickler syndrome caused by biallelic type IX collagen gene mutations and none or mild hearing loss for the non-collagen genes. Inherent to the orofacial manifestations, middle ear problems and temporary conductive hearing loss, especially at young age, are also prevalent. Consequently, hearing loss should be actively sought for and adequately treated in Stickler syndrome patients given its high prevalence and the concomitant visual impairment in most patients.".
• 01GRVBDQD6SH7N34MQRKXGYG3F abstract "This paper establishes an indoor distributed radar-like prototype using a sub-6 GHz massive multiple-input multiple-output (MIMO) communication system. Based on the prototype, the contact-free human tracking performance is experimentally evaluated. Instead of extracting the location related geometrical metrics (angle and distance), we propose to localize the pedestrian through the channel state information (CSI) directly. Inspired by the concept of synthetic aperture, a particle filter-based hologram tracking algorithm is proposed. The experimental results show that the proposed algorithm can achieve 20.1-cm mean tracking accuracy in real-time.".
• 01GRVBTPX90T9KH84RBG9JREQJ abstract "Ultra-wideband (UWB) indoor positioning systems have the potential to achieve decimeter-level accuracy. However, the performance can degrade significantly under Non-Line-of-Sight (NLoS) conditions. Detection and mitigation of NLoS conditions is a complex problem, and has been the subject of many works over the past decades. When localizing pedestrians, human body shadowing (HBS) is an important cause of NLoS. In this paper, we propose an HBS mitigation strategy based on the orientation of the body and tag relative to the UWB anchors by attaching an inertial measurement unit to the UWB tag. Two algorithms are designed and implemented, of which the second algorithm is designed for robustness against errors in the IMU's estimated heading. The proposed algorithms are validated by UWB Two Way Ranging (TWR) measurements, performed in two environments. Two more algorithms are implemented as a benchmark, of which one is based on the estimated first path power, and the other is based on range residuals. The proposed algorithm outperforms the other algorithms in the higher error statistics, achieving a 49% reduction of the p90 error depending on the environment.".
• 01GRVC6R4VK5T6SM8GP0Q7Y3MW abstract "There is a paucity of literature on the minimum number of cases necessary to become an expert surgeon in hip resurfacing arthroplasty (HRA). Thus, we aimed to describe (I) the learning curve of a primary hip replacement; (II) the learning curve of HRA using different end-points (complications, joint survival, component alignment and patient-reported outcome measures); and (III) what the minimum number of cases performed per year should be to maintain competency. A comprehensive literature search was performed reviewing joint arthroplasty registries, case-controlled studies, and case-series that have reported on the above. The reported learning curve necessary to decrease the overall complication rate in primary total hip arthroplasty (THA) is 90 cases. Additionally, the literature suggests that at least 35 primary THA cases per year is the recommended number above which complications reduce significantly. There is no doubt that only surgeons trained in primary hip replacement should perform HRA of the hip. On average, a learning curve of 50 cases has been described. Following this threshold, less complications, better radiographic assessment and superior patient reported outcomes have been described. It is the authors' opinion that at least 25 cases should be performed annually, which is in line with other highly specialized surgical procedures.".
• 01GRVENFGH0S0FPS10BKN3NEGQ abstract "In this contribution, the authors examine the spatiotemporal distribution of residential burglaries in a Belgian police zone based on monthly residential burglaries before and during the COVID-19 crisis and assess the performance of a predictive crime model during this period. In general, compared to 2019, there were fewer home burglaries in 2020 during the COVID-19 crisis. Except for a few changes, the spatial distribution of residential burglaries in 2020 is largely similar to that of residential burglaries in 2019. The authors observe that the predictive crime model performs significantly worse at the start of the pandemic and when severe measures are taken, but that the model’s performance then rises again after a few months as the algorithm becomes more proficient in adjusting itself to big societal changes.".
• 01GRVKKMA3GYRKXYG5C221CWS1 abstract "In the era of molecular biology, identification of cells and even tissues mostly relies on the presence of fluorescent tags, or of “marker gene” expression. We list a number of caveats and present a protocol for embedding, sectioning, and staining semithin plastic sections. The method is neither new nor innovative, but is meant to revive skills that tend to get lost. This easy-to-use and inexpensive protocol (1) yields high-resolution images in transmitted and polarized light, (2) can be utilized simultaneously for transmission electron microscopy, and (3) is applicable to any type of material (wild type, morphants, mutants, transgenic, or pharmacologically treated animals as well as all of their controls), provided the sample size is kept under a limit. Thus, we hope to encourage researchers to use microanatomy and histology to complement molecular studies investigating, e.g., gene function.".
• 01GRVKV22NT61SFKKA56VV99GB abstract "The discovery of the notochord as a feature uniting all chordates arose from comparative embryological studies in the 19th century. This discovery established cephalochordates, ascidians (tunicates) and vertebrates as chordates. Hemichordates, initially included as chordates, came to be excluded when it was recognized that the hemichordate stomochord is not homologous with the notochord. This chapter examines the history of the search for chordates and early vertebrates in the fossil record, where the notochord is usually poorly preserved or not preserved at all. This discussion includes analysis of candidate vertebrates in the fossil record. The close resemblance between the notochord and notochordal cells (chordoblasts) and cartilage and cartilage cells (chondroblasts) has complicated interpretations of the nature of the notochord and of its origin – whether in the first chordate or in an earlier invertebrate ancestor – whether that ancestor was segmented or not – and whether the notochord is segmented. It has long been known that the anlagen of vertebral centra in teleosts are formed by segmented mineralisation of the notochord sheath. Recent studies on zebrafish and medaka embryos have uncovered the molecular mechanisms of a somite-independent notochord-driven segmentation process that establishes vertebral centra and intervertebral spaces. The fact that segmented mineralisation of the notochord sheath is not restricted to teleosts and evolved much earlier requires a new interpretation of the origin of vertebral bodies. Paleontology and developmental biology have reinforced one another in the search to understand the nature and evolutionary origin of the notochord and the vertebral column.".
• 01GRW0YYSQ8F8QJXFB0DWJB5VS abstract "Employing luminescence thermometry in the biomedical field is undeniably appealing as many health conditions are accompanied by temperature changes. In this work, we show our ongoing efforts and results at designing novel vehicles for dual-mode thermometry and pH-dependent drug release based on hollow spheres. Hereby for that purpose, we exploit the hollow Y2O3 and Y2O2SO4 host materials. These two inorganic hollow phosphors were investigated and showed to have excellent upconversion Er3+-Yb3+ luminescence properties and could be effectively used as optical temperature sensors in the physiological temperature range when induced by near-infrared CW light (975 nm). Further, doxorubicin was exploited as a model anti-cancer drug to monitor the pH-dependent drug release of these materials showing that they can be used for simultaneous thermometry and drug delivery applications.".
• 01GRW27KR1TDN9378GHEE6X7XH abstract "Time Series. Individual but averaged time series of tibial accelerations across the stance phase of running gait. Metrics. Individual metrics of each participant in each running condition. Pre: first running session, post: second running session, APTA: axial peak tibial acceleration, RPTA: resultant peak tibial acceleration, VLR: vertical loading rate of the ground reaction force. Subject names have been abbreviated to preserve confidentiality.".
• 01GRW2GR0H44MXGBQWQ9RS655M abstract "This dataset contains the time series of axial peak tibial acceleration. We recruited 10 runners with high axial peak tibial acceleration. The participants performed a gait retraining session whilst running overground at 3.2 ± 0.2 m/s in self-selected footwear. Real-time auditory biofeedback on axial peak tibial acceleration was provided. The axial peak tibial acceleration was detected before and during the biofeedback-based intervention using a backpack system connected to a very lightweight accelerometer. We refer to the full paper for details on how the data were collected and processed. Data are from an experimental protocol approved by the Ethics Committee of Ghent University (bimetra identification number 2015/0864). The present dataset has been used to determine when runners change their level of peak tibial acceleration during over-ground running using an auditory biofeedback system. The folder 'Change-Point" contains the .cpa-files to be opened in the Change-Point Analyzer v2.3 software. The values of axial peak tibial acceleration are also stored in an Excel-compatible file 'change point analysis_data' . The spreadsheet comprising of 10 columns. Each column represents a participant. A column contains the values of axial peak tibial acceleration of the no-biofeedback condition (1.5 min. of baseline), followed by the biofeedback condition (2x10 min.). The total number of trials detected per participant equals 1853 ± 88 (mean ± SD).".
• 01GRW338TK4YCQQNZYNKJ5M6FE abstract "Welcome to the repository associated with the manuscript titled: “One hundred marathons in 100 days: Unique biomechanical signature and the evolution of force characteristics and bone density”, accepted for publication in the Journal of Sport and Health science (add DOI). The study presents a biomechanical profile of a successful long-distance runner. The case was compared to a normative group of distance runners who were matched by foot strike pattern. The case scheduled 100 marathons in 100 days and was followed in time by the research unit Biomechanics of Human Movement of Ghent University. The pre-test was one of the first test sessions that took place in the Sport Science Laboratory-Jacques Rogge. We refer to the full paper for details on how the data were collected and processed. By making snapshots of the data available to you we aim to increase transparency of our study, enhance the visibility of our research in running biomechanics, and perhaps create new opportunities for collaboration. WHAT IS INCLUDED? This public repository contains the spreadsheet used for statistical analysis, editable figures, the video fragments, and a link to the paper. The paper was accepted for publication in the journal of Sport and Health Science in January 2021. We were encouraged by the journal to include an AudioSlides presentation and an infographic with the published article. AudioSlides were created to summarize the main results in a webinar-style presentation next to the online article. Please contact Pieter Van den Berghe if you have questions regarding the paper. CITATION If you make use of the provided content in your work or research, please cite us in your publications or on the web. Pieter Van den Berghe, Bastiaan Breine, Ella Haeck, Dirk De Clercq,. (2021). Data from: “One hundred marathons in 100 days: Unique biomechanical signature and the evolution of force characteristics and bone density” [Data set]. OSF.".
• 01GRX0PYNMY1QBMCKWJ1XJPDZV abstract "Impulsivity is a multifaceted construct that relates to different behaviors in everyday life and has been associated with many psychopathological disorders and behavioral problems, such as problematic gambling behavior. One questionnaire to measure these several facets on a trait level is the UPPS-P Impulsive Behavior Scale. Specifically, the UPPS-P investigates five distinct facets: (a) negative urgency, (b) lack of premeditation, (c) lack of perseverance, (d) sensation seeking, and (e) positive urgency. Negative urgency at a trait level in particular seems to be associated with the development of psychopathological disorders. To date, there are no established state measures of negative urgency. However, it was recently proposed that speeding after losses might be a suitable measure. Thus, in this study, we explored the possible relationship between a state measure of negative urgency modeled through a behavioral gambling task and a trait measure of negative urgency through the UPPS-P questionnaire. We used correlational and network analyses in an aggregated database of eight samples (total N = 1216) to explore the potential relationships between post-loss speeding on the behavioral gambling task and UPPS-P scores (by combining trait vs. item-based analyses). We found that the degree of speeding after losses (post-loss speeding) did not correlate with the trait measure of impulsivity in general and negative urgency specifically, either at the latent trait level or on an item-based level. This null finding indicates that our state measure of post-loss speeding and negative urgency on a trait level does not seem to capture the same underlying constructs. Implications for personality research are discussed.".
• 01GRX4ATJBEVFTQ550YMGRRR48 abstract "Chemically bonded anchors are connecting elements that allow transfer of stresses by adhesion. Their strength and failure mechanism depend on the concrete's confinement, properties of the bonding agent and the installation method. Several investigations on their sustained load behavior have been performed and current standards have adopted the use of prediction laws for the determination of the total displacement throughout their service life which serves as an assessment criterion. Although the displacement criterion is a conservative assessment method it does not provide any direct information on the failure time with respect to the sustained load or the testing temperature. The aforementioned problem is overcome by the stress vs. time to failure-assessment method where the long-term behavior of bonded fasteners is assessed by extrapolating actual failure times. Even though knowledge of the time-to-failure of bonded anchors is crucial, their accurate lifetime prediction is still a challenge. This research aims at investigating the long-term behavior of chemically bonded anchors by means of an experimental campaign consisting of a series of tensile sustained load tests in a confined configuration. Two products are tested and different geometry variations are considered. Each configuration consists of a set of short-term pull-out tests to determine the ultimate pull-out capacity. The ultimate laod is then used to defiine the load levels for long-term tests which are applied to a limited number of specimens and the time to failure is recorded. The obtained results are used to construct time-to-failure (TTF) curves of the anchor sets. the lifetime prediction of the anchors is assessed by applying a new model based on a sigmoid function. Finally, statements on the robustness of the procedure and discussions of the long-term assessment of adhesive anchors and the potential presence of post-curing effects are presented.".
• 01GRX5309PTWHWECX2G7Y0TH9V abstract "The growing adoption of fiber reinforced concrete (FRC) as a structural material is motivating plenty of research in this field, especially those regarding the experimental aspects and the development of numerical models. The composite nature of the material suggests that the final mechanical performance is due to the contribution of both components and to their interaction. In this respect, the experimental research has a fundamental importance for the identification of the mechanical response scatter, as the natural heterogeneity of concrete is further incremented by the randomness of fiber distribution. When the mechanical behavior of FRCs is simulated numerically, this aspect needs to be properly reproduced to get a reliable response of the fiber reinforced concretes. In this framework, the present paper illustrates a numerical model describing the behavior of a FRC concrete reinforced with polymeric fibers, developed with the Lattice Discrete Particle Model (LDPM). This theory is able to reproduce the behavior of only concrete (LDPM), by describing the mechanical interaction between the aggregates, and also the interaction with fibers (LDPM-F). The model has been already validated for the plain concrete short- and long-term behavior (MLPDM); in the recent years, the fiber-bridging action due to the reinforcement has been introduced. Many numerical parameters concerning the fiber geometry and its mechanics determine the whole response: the discretization of each fiber, the definition of its shape, its elastic modulus and also the orientation of the fibrous reinforcement in the concrete matrix. Furthermore, polymeric fibers may be characterized by a crimped profile to improve the matrix-to-fiber bond and, so, it is fundamental to consider their actual shape also numerically. Their geometry is defined by the number of segments in which each fiber is divided and its tortuosity. This paper performs a parametric analysis of these specific aspects showing how they affect the flexural behavior of macro-synthetic fiber reinforced concrete beams. The fiber elastic modulus handles the force transferring when concrete is cracked so defines the post-peak strength in the flexural behavior: a value between the tangent and secant elastic modulus has to be considered in the calibration. The orientation of the reinforcement, especially in the crack surroundings, drives the crack development: the randomness is what influences more the scatter in the response that, in turn, depends on the number of fibers connecting the crack. In this numerical approach the counting of fibers has been also performed and, at a given fibers dosage, the orientation is a parameter calibrated to make the numerical count close to the experimental. Finally, regarding the concrete composition, the aggregates are here generated according to the minimum and maximum size: the minimum value given is shown to influence the post peak behavior especially in terms of cracking evolution under flexural load.".
• 01GRX71G6QGE0B9D54HXJG6V64 abstract "Bacillus thuringiensis (Bt) is commonly used as a biological control agent (BCA) to control insect pests in edible plant production and can as such be introduced into the food chain of fresh produce. Using standard food di-agnostics Bt will be detected and reported as presumptive B. cereus. Tomato plants are often sprayed with Bt biopesticides for insect control, thus these Bt BCAs can also reach the tomato fruits and persist until consumption. In this study, vine tomatoes from the retail in Belgium (Flanders) were investigated for the occurrence and re-sidual numbers of presumptive B. cereus and Bt. Of 109 tomato samples, 61 (56%) were tested positive for presumptive B. cereus. Of the presumptive B. cereus isolates (n = 213) recovered from these samples, 98% were identified as Bt by the production of parasporal crystals. Further quantitative real-time PCR assays on a sub -selection of Bt isolates (n = 61) showed that 95% of Bt isolates were indistinguishable from Bt biopesticide strains that are approved to be used on crops in the EU. Furthermore, the attachment strength of tested Bt biopesticide strains showed easier wash-off properties if using the commercial Bt granule formulation than the unformulated lab-cultured Bt or B. cereus spore suspensions.".
• 01GRX7ETWXVA27RFK7E9NCBEGY abstract "Chemical solution deposition (CSD) approach was introduced in this work to simplify and to optimize the trifluoracetic based M TiO 3 ( M TO, M = Ca, Sr, and Ba) precursor solution, leading to the high shelf-life and the purity. Growing these M TO solutions on (100) LaAlO 3 single-crystal substrates yields (h00) oriented and dense M TO buffer layers. Whereas it is clear that the roughness of M TO films and the lattice mismatch between M TO buffer layer and superconducting YBa 2 Cu 3 O 7-δ film is crucial for the film formation.".
• 01GRX7MYAJ9V1QKJSCK7K6NY0T abstract "This dataset contains RAW data of BaTiO3, CaTiO3 and SrTiO3 buffer layer on LaAlO3 substrate and YBCO grown MTO-buffered substrates. Several techniques such as TGA, SEM and XRD were introduced.".
• 01GRX9FS10V6ZFQS5GJSYSEDXM abstract "A preliminary study of two approaches for the internal structure generation utilized in the lattice discrete particle models (LDPM) [1] is presented. The presented methods used for particle generation and placement are meant to capture the internal structure of materials realistically. The first approach governs the positioning of the generated spherical particles by a gradient field to mimic the casting process. The second approach considers the non-spherical shape of individual particles, i.e. ellipsoidal particles. Therefore, the grain size, angularity, and flakiness can be controlled to match the real grain distribution closely.".
• 01GRXDEX1M9XXV6XSSN5B67Z3Y abstract "The mechanical performance of fibre reinforced concrete presents aspects still under investigation, mostly those regarding the long-term behaviour. Even if creep and shrinkage are two well-known phenomena that characterize concrete, in case of FRCs, and in particular of macro-synthetic Fiber reinforced concretes (MSFRCs), there are no reliable models for predicting their long term-behaviour, because of the interaction between concrete, fibre creep and bond. In addition, temperature is a further variable to control since it affects the material performance. In this perspective, the present paper shows the experimental results of a large campaign of creep tests performed on macro synthetic fibre reinforced concrete specimens. The material tested had a compressive strength of about 55 MPa and it is reinforced with 8 kg/m3 of polypropylene crimped fibres. The experimental investigation is carried out by performing creep compression tests on cylinders and direct tensile test on notched cylinders. In addition, the tensile behaviour of the single fibre under sustained load is analysed. The tests were conducted in a humidity and temperature controlled chamber. Furthermore, the temperature was increased from 20 °C to 30 °C after a time of 50 days of testing in order to understand how this condition modifies the creep deformations evolution of the material. The paper shows also the initial calibration of a numerical model based on the Lattice Discrete Particle Model (LDPM) theory. The LDPM is one of the most validated theories able to reflect the actual coarse aggregate distribution of a quasi-brittle material, i.e. concrete. Currently this theory has been extended to include the fibres reinforcement. The aim of the big study presented would be to elaborate a predictive model for the MSFRCs accounting also for concrete and polymers long term behaviour.".
• 01GRXEG7P5YZFDKYDBSZHDCCG6 abstract "The paper aims at characterizing the influence of particle placement and clustering in lattice discrete particle model (LDPM) simulations of concrete on structural response. The presented spatial variability package for LDPM enables for the first time to influence the previously independent and random particle placement. The proposed scheme correlates the particle placement to an initial random or gradient-based fields in order to mimic some of the experimentally observed phenomena such as aggregate clustering or the effect of casting direction. The study is based on high-dimensional Monte Carlo (MC) LDPM simulations of three classical concrete tests in which the inherent variability and production process are represented by the proposed particle placement schemes with varying parameters. The material property fields are kept constant at this phase of the investigation in order to isolate and quantify the potential effect of the proposed particle placement schemes on structural response. This investigation is based on a comparison of stress and strain values at peak for different tests against the case of independent and random placement. The coefficients of variation of the above-mentioned outputs are also evaluated. This research aims at evaluating the importance influencing the particle placement according to experimentally measurable phenomena before initiating research on the spatial variability of material properties and the respective correlation structure.".
• 01GRXFDG3JJ59EWGDMT7JFD3F1 abstract "Purpose: Lower urinary tract symptoms (LUTS) are common in patients with cerebral palsy (CP). Although recommended in typically developing children, uroflowmetry is not routinely used in children with CP. The objective of the study is to investigate uroflow measurement in children with CP with and without LUTS. Patients and methods: A cross-sectional observational study is conducted including children with CP between five and twelve years old. Children are evaluated using uroflowmetry followed by an automated evaluation of post void residual urine. Two to three toilet moments with a personally adapted toilet chair are caried out. Data concerning LUTS are collected by means of the validated Dutch Vancouver Symptom Score for Dysfunctional Elimination Syndrome (VSSDES) questionnaire. Results: The study will be conducted between 2021 and 2023 and is therefore still ongoing. Twenty-seven children have been included in the study, with a mean age of 8,44 years old and 59 % of them being male. 15 children (55%) were dry, 5 (19%) had isolated daytime incontinence, 3 (11%) had isolated enuresis and 4 (15 %) had combined daytime incontinence and enuresis. A bell-shaped curve was most frequently seen and demonstrated by 14 (52%) children. No significant difference was present in the amount of bell-shaped curves in the group with or without incontinence (p = 0,44). However, the group with combined daytime incontinence and enuresis demonstrated no bell-shaped curves. Voided volume as percentage of expected bladder capacity for age tended to be lower (40,6 % vs. 59,8 %) and PVR as percentage of voided volume tended to be higher (17 % vs. 7 %) in the children with incontinence, but no statistical difference was established. Conclusions: Uroflow abnormalities are frequent in children with CP. Results could improve the use and interpretation of uroflow measurement in children with CP.".
• 01GRXG37D15JTVKERVT1NTDETR abstract "This article investigates to what extent technological affordances are associated with people's preference for video streaming platforms over traditional television services. Such affordances refer to properties of these platforms (including personalized recommendations and easy-to-navigate interfaces) that provoke certain uses of the technology and satisfy social and psychological needs. Based on a quantitative study of 25–50-year-olds in Belgium ( N = 596) and a hierarchical regression analysis, the study builds further on the conceptualization of technological affordances as presented in the MAIN model, which suggests that four affordances (Modality, Agency, Interactivity and Navigability) are central to digital media technology. As such, the study presents an affordance-based measure of video streaming platforms, and helps to understand how video streaming technology shapes new patterns of audiovisual consumption and enhances the viewing experience beyond that of traditional television. Whereas most research attention has focused on user-oriented gratifications of video streaming platforms, this study addresses a gap in the literature by dealing with platform-oriented gratifications of video streaming platforms.".
• 01GRXHRCNSJMS2KDYEMG9ZMSNP abstract "The postglacial sea-level rise after the Last Glacial Maximum provided ideal conditions to study the transgressive sedimentary response to sudden shelf flooding driven by different rates of sea-level rise. In this study, a high-resolution seismic stratigraphic interpretation and sedimentological analysis were conducted on data from the northern Gulf of Cadiz continental shelf (SW Iberian Peninsula), in order to: 1) understand the succession of sedimentary processes during each shelf flooding episode and 2) explore the significance of variable rates of sea-level rise, sediment fluxes, and climatic conditions on the development of postglacial deposits. Four backstepping seismic postglacial transgressive units (PTUs; 4 to 1 from oldest to youngest) that are linked to the retreating mouth of the Guadiana River were interpreted. Together, these seismic units display a wedge-shape geometry, are located over the inner to middle shelf, and overlie a regional unconformity formed during the Last Glacial Maximum. Each PTU can be divided into several sub-units with distinctive seismic facies that have a similar stratigraphic organization. Each PTU contains lower sub-units that are composed of low-angle tangential-oblique clinoforms. The clinoforms are locally topped by a channelized sub-unit. The distal and/or lateral parts of the clinoforms are occasionally buried by sheet-like semitransparent subunits. The uppermost sub-units are present over the proximal and central parts of each seismic unit and are also sheet-like. PTUs can also be subdivided and described sedimentologically. Fine-grained sands with intercalated silty layers dominate the lower part of each PTU (lower clinoform sub-units). The upper part of each PTU (upper sheet-like sub-units) is characterized by reworked facies, composed of highly fragmented bioclasts within a mixture of silt and coarse to medium sand. Finally, mud deposits occur as a sediment drape over the PTUs. The internal structure of each PTU reveals several phases of development under a general process of transgressive submergence in which both coastal and marine deposits were formed and eventually preserved. The initial phase involved the development of coarse-grained deltas in shallow water, which were locally eroded by a network of distributary channels. In a transitional phase, the infilling of distributary channels and the offshore export of fine-grained sediments is related to a change in sediment sources, possibly triggered by enhanced hydrodynamic processes. The final phase involved the reworking of fluvio-deltaic sediments by shoreface processes to generate a sediment sheet. Age correlation with a suite of postglacial sea-level curves indicates that the formation of the postglacial transgressive deposits is bracketed between 14 ka and 9 ka. The studied deposits are related to a period of reduced sea-level rise, culminating in the Younger Dryas event (two oldest PTUs), and to phases of enhanced sea-level rise, such as Meltwater Pulse (MWP) 1B (two youngest PTUs). In spite of high rates of sea-level rise over MWP-1B, each PTU exhibits progradation and preservation of much of the delta. The preservation of progradational deltaic units is likely caused by increased sediment supply during progradational pulses. We suggest that those pulses of enhanced sediment fluxes during MWP-1B were strongly driven by the overall climatic conditions in the southwest of the Iberian Peninsula, probably resulting from enhanced rainfall runoff during humid periods and scarce land vegetation cover.".
• 01GRXJ5ESCXE3ZFYQHB1XW864S abstract "Purpose: Standard urotherapy is first-line treatment for LUTS in functional disorders. The study investigates effectiveness of group therapy or voiding class on symptom reduction and quality of life in children with LUTS. Patients and methods: A prospective cohort study is conducted including children, aged five to twelve, with LUTS. Voiding class takes place four weeks after recruitment and is followed with a follow-up consultation eight weeks after voiding class. During voiding class children receive standard urotherapy following ICCS guidelines in groups of four children. Data is collected before and after voiding class through a frequency-volume chart for three days, a bladder diary for fourteen nights and the validated Dutch Vancouver Symptom Score for Dysfunctional Elimination Syndrome (VSSDES) and Pediatric urinary incontinence Quality of life (PIN-Q) questionnaires. Adherence was evaluated by means of the amount of documents filled in before and after voiding class. Results: The study will be conducted between 2021 and 2023 and is therefore still ongoing. Twenty-four children have completed the voiding class and follow-up period. Children had a mean age of 7,43 years old and 75 % of them were male. Twelve children had combined daytime incontinence and enuresis, eleven children had isolated enuresis and one child had isolated daytime incontinence. Eight weeks after voiding class a statistically significant decrease in the VSSDES (p = 0.04) and adherence (p = 0.01) was found. Bladder capacity tended to increase although not statistically significant (p = 0.18). No changes concerning quality of life were seen on group level, although on individual level some children demonstrated a decrease in quality of life whereas others demonstrated an increase in quality of life. Conclusions: Preliminary results demonstrate effectiveness of group standard urotherapy. However, a high individual variability and low adherence was noted in the present study.".
• 01GRXJAV2BEFBHMADFF0R98ZBH abstract "The Bransfield Strait (Antarctica) is an important region for evaluating changes in Weddell Sea shelf waters on geological time scales because of its restricted connections to the surrounding ocean. However, the detailed oceanographic consequences of the opening of the strait remain unclear. We present bottom-current-related sedimentary features in the Bransfield Strait and examine the impact of the strait's opening on deep-water circulation. Our findings show that the ocean circulation started to resemble that of the present day after a period of volcanic activity, possibly around the Middle Pleistocene. Coeval changes in Bransfield Strait morphology and an increase in seafloor irregularities due to the formation of volcanic chains finally determined new pathways for the Bransfield deep and bottom waters, enhanced due to the new climatic scenario of 100 k.y. cycles. The fact that "modernlike" oceanic circulation occurred only during previous interglacial periods demonstrates the significant impact of 100 k.y. climate cycles on the thermohaline changes of Antarctic deep waters. Hence, establishing a modern-day circulation model would enable researchers to assess paleoproductivity and local upwelling that have profoundly influenced the marine ecosystem of the Antarctic Peninsula after the Middle Pleistocene.".
• 01GRXJGD6F8M5PDAFPHQP6F8FZ abstract "Background and Objectives The aging population places increasing demands on our healthcare system. Mobile health offers the potential to reduce this burden. The aim of this systematic review is to thematically synthesize qualitative evidence of older adults' user engagement toward mobile health, and to generate relevant recommendations for intervention developers. Research Design and Methods A systematic literature search was performed in Medline, Embase, and Web of Science electronic databases from inception until February 2021. Papers on qualitative and mixed-methods studies that investigated older adults' user engagement with a mobile health intervention were included. Relevant data were extracted and analyzed using thematic analysis. The Critical Appraisal Skills Program Qualitative Checklist was used to assess the quality of the included studies. Results Thirty-two articles were deemed eligible for inclusion in the review. Three overarching analytical themes emerged from the 25 descriptive themes generated by the line-by-line coding: the limited capabilities, the prerequisite of motivation, and the importance of social support. Discussion and Implications Successful development and implementation of future mobile health intervention for older adults will be challenging given the physical and psychological limitations and motivational barriers that older adults experience. Design adaptations and well-thought-out blended alternatives (i.e., combining mobile health with face-to-face support) might be potential solutions to improve older adults' user engagement with mobile health interventions.".
• 01GRXK7H3G765PBRE6Y8JB4NSD abstract "X-ray fluorescence, grain-size and oxygen and carbon stable isotope measurements of a 33 m long piston core, recovered from the Pen Duick drift located at the foot of the prominent Pen Duick Escarpment (Atlantic Moroccan margin), are combined to decipher past oceanographic conditions. The data indicate that, similar to the northern Gulf of Cadiz, the Azores Front exerts a major control on the palaeoclimatology of the region. Contrasting the northern Gulf of Cadiz, where Mediterranean Outflow Water is the main water mass at similar water depths, the palaeoceanography of the studied area is mostly influenced by the amount of Antarctic Intermediate Water advected from the south. The density contrast between the Antarctic Intermediate Water and the overlying North Atlantic Central Water determined the strength of the prevailing internal tides and corresponding high current speeds, which drastically impacted the sedimentary record. The most notable impact is the presence of a 7.8 kyr condensed section (30.5-22.7 ka bp). The formation of the Pen Duick sediment drift was not just controlled by the strength of the bottom currents and the intensity of the internal tides, but also by the amount of (aeolian) sediment supplied to the region. Although variable, drift-growth phases seem to mainly occur during colder periods of the last glacial, that is Heinrich and Dansgaard-Oeschger events during Marine Isotope Stage 3 and late Marine Isotope Stage 2. These periods, characterised by increased aeolian dust supply and higher bottom currents, coincide with a phase of prolific cold-water coral growth and enhanced coral mound formation as recorded in numerous cores obtained from the southern Gulf of Cadiz. This implies that both records (on and off mound cores) are pivotal to provide the complete picture of the palaeoclimatic and palaeoceanographic conditions in the region.".
• 01GRXM708MXN9W6XKX0WN22095 abstract "Media exposure for dark consumption products mostly shows glamorized and positive portrayals, rarely showing the negative consequences of consuming those products. However, the Netflix series Squid Game addresses the issue of gambling in its most extreme forms and shows the negative consequences related to it in a shocking manner, which begs the question whether watching the series could act as a preventive tool to increase risk perceptions, de-normalize gambling and reduce gambling behavior. A pre-registered survey study (N = 271) examined whether watching the Netflix series Squid Game affected young adults' (18 to 35 years old) gambling intentions and play behavior through risk perceptions, subjective norms and attitudes toward gambling, and what role audience involvement plays. Although the results show that watching Squid Game increased young adults' subjective norms of gambling (i.e. belief that significant others approve of the behavior in question) and further increased their positive attitudes toward gambling and gambling intention, the study also found an important impact of audience involvement. Audiences who were more involved with the series saw greater risks of gambling and perceived gambling to be less common. This resulted in more negative attitudes toward gambling and further less gambling intention and more motivation to change gambling behavior due to watching Squid Game.".
• 01GRXMFK2QXB19W5EQXFMBT7KT abstract "Consider the Klein quadric Q(+)(5, q) in PG(5, q). A set of points of Q(+)(5, q) is called a quadratic set if it intersects each plane pi of Q(+)(5, q) in a possibly reducible conic of pi, i.e. in a singleton, a line, an irreducible conic, a pencil of two lines or the whole of pi. A quadratic set is called good if at most two of these possibilities occur as pi ranges over all planes of Q(+)(5, q). We obtain several classification results for good quadratic sets. We also provide a complete classification of all good quadratic sets of Q(+)(5, 2) and give an explicit construction for each of them.".
• 01GRXMS5N9Q1X32RYG7HVM1A27 abstract "Let H be a hyperplane of the Grassmannian of the k-dimensional subspaces of the projective space PG(n, F), 0 <= k <= n - 1, and let (H) over tilde denote the subgeometry of the Grassmannian induced on the point set H. We prove that the embedding and generating ranks of (H) over tilde are always equal to ((n+1)(k+1)) - 1.".
• 01GRXMX38AFNKBWQZ269P4AQA8 abstract "In this paper, we complete the classification of the caps in PG(n, q) having the property that on every tangent line L, there exists a unique point distinct from the tangency point though which there is at least one secant line. The examples include the Coxeter cap in PG(5, 3) related to the Mathieu group M-12, a set of three noncollinear points in PG(2, q) and some examples related to hyperovals of projective planes.".
• 01GRXN14TJ1ZTDP2KCWSYHST7Q abstract "Objective: Up to one in four patients living with epilepsy (PwE) mentions financial constraints as a reason for loss to follow-up at the Ndera tertiary neuropsychiatry hospital. Therefore, we evaluated the annual direct medical cost (DMC) and direct non-medical cost (DnMC) of epilepsy and calculated costs assuming different follow-up frequency. Materials and Methods: DMC data were obtained from a descriptive retrospective study of medical records, pharmacy dispensation and hospital logs of PwE, following their initial consultation in 2018 and who adhered to the normal clinical practice of monthly consultations for one year. DnMC data were collected through structured interviews of PwE in a cross-sectional cohort in August 2020. DnMC included biomedical care costs (eg, transportation, hospitality) and non-biomedical costs (traditional healer visits). We report weighted means for total costs, health insurance costs, and out-of-pocket costs (OoP). Results: Mean annual total cost was 389.4 US$, of which 226.2 US$ was covered by the Rwandan Health Insurance co-payment for DMC and 163.2 US$ was OoP paid by patients. Mean weighted annual DMC (n = 55) was 248.9 US$. Mean weighted annual DMC for medical consultations and antiseizure medication accounted for 30.7 US$ and 161.7 US$, respectively. Based on structured interviews (n = 69), mean weighted annual DnMC for biomedical care was 73.0 US$. Mean DnMC for traditional healer care was 67.6 US$. Weighted annual total OoP was 163.2 US$ or 20% of the GDP per capita. OoP consisted of 14% DMC co-payment, 45% biomedical DnMC, and 41% traditional healer DnMC. Conclusion: Epilepsy-related costs at a tertiary center are an important economic burden for PwE and Rwandan Health Insurance. Biomedical and traditional healer DnMC constitute 86% of total OoP. Future prospective studies should evaluate outcomes and costs of reduced visit frequency, indirect costs, and costs of comorbidities.".
• 01GRXQ8098WDJEWNXA6M45A0MG abstract "Remakes, sequels, reboots, spin-offs, and other forms of imitative filmmaking are part of ‘recycle film cultures’ and have become a central part of commercial filmmaking globally (Forrest & Koos, 2002; Cuelenaere, Willems & Joye, 2021). Research concerning this phenomenon has been mainly focused on Hollywood due to its dominant position in the film industry (Klein & Palmer, 2016; Henderson, 2014). However, while Hollywood is undeniably prolific in imitative filmmaking, recycle film cultures are not limited to the US, with Europe taking part in the practice as well. Meir (2019) demonstrates how these recycling forms have started to manifest themselves in large European film industries since the early 2000s. Although recycle film cultures are seemingly on the rise in small European film markets as well, these countries have received little critical and scholarly attention on the topic. Therefore, this research project will investigate how, why and with what economic and cultural implications small Western European film industries increasingly implement these practices. European countries with small domestic markets which depend on governmental support and deal with lower ticket sales (Hjort & Petrie, 2007: 6) appear to produce more and more sequels, remakes and other forms of adaptations since these types of imitative filmmaking proved to carry less financial risks with them while also guaranteeing some commercial success (Cuelenaere et al., 2021; Hutcheon, 2012; Joye, 2009). Using Belgium, Denmark, and the Netherlands as case studies, we will explore the rise in recycle film cultures in small Western European countries with three objectives in mind. Firstly, mapping the recycle film cultures in these countries from the 2000s onwards, researching what kind of films (genre, budget, admissions…) and which actors (institutions, directors, distributors…) are central to this practice. Secondly, exploring how and why this practice is becoming more popular in these countries and what its cultural and political implications are. Lastly, analysing the critical reception and audience perception of these types of filmmaking. To investigate the full extent of the industrial, economic and cultural dynamics and implications of recycle film cultures in small Western European film industries, this research will apply a multimethodological framework, using both quantitative and qualitative research methods. To map the case studies’ recycle film cultures, we will set up a database of all feature-length fiction films (excluding minority co-productions) produced and released in the selected countries between 2000 – 2021 and conduct a network analysis on the same dataset. Next, interviews with industry experts and the analysis of promotional, production, and distribution material will give insight into the industrial side of this phenomenon. Moreover, the research project will analyse prominent recycled films of the studied countries to reveal how, for example, certain ideological and cultural ideas are reinforced through media representations. Finally, focus group interviews and qualitative critical reception analyses of these same examples will be used to understand the reputation and general perception of this phenomenon. With its focus on recycle film cultures in small Western European film industries and popular European cinema, this research delves into two topics of European cinema which have been largely neglected in scholarly studies (Klein & Palmer, 2016; Smith & Verevis, 2017; Galt & Schoonover, 2010).".
• 01GRXS42VTYW9HWHE7RWZYS1GR abstract "Aim To compare connective tissue graft (CTG) with collagen matrix (CMX) in terms of increase in buccal soft tissue profile (BSP) at 1 year when applied at single implant sites. Materials and Methods Patients with a single tooth gap in the anterior maxilla and horizontal mucosa defect were enrolled in a multi-centre randomized controlled trial. All sites had a bucco-palatal bone dimension of at least 6 mm, received a single implant and an immediate implant restoration using a full digital workflow. Sites were randomly allocated to the control (CTG) or test group (CMX) to increase buccal soft tissue thickness. The primary outcome was the increase in BSP at 1 year when compared with the pre-operative situation based on superimposed digital surface models. The changes in BSP over time were registered at a buccal area of interest reaching from 0.5 mm below the soft tissue margin to 4 mm more apical. Secondary outcomes included patient-reported, clinical and aesthetic outcomes. Results Thirty patients were included per group (control: 50% females, mean age 50.1; test: 53% females, mean age 48.2). The increase in BSP at 1 year was 0.98 mm (98.3% confidence interval [CI]: 0.75-1.20) for CTG and 0.57 mm (98.3% CI: 0.34 to 0.79) for CMX. The mean difference of 0.41 mm (98.3% CI: 0.12 to 0.69) in favour of CTG was significant (p < .001). Based on an arbitrarily chosen threshold for success of 0.75 mm increase in BSP, 89.7% of the patients in the control group and 10% of the patients in the test group were successfully treated (odds ratio = 77.90; 95% CI: 13.52 to 448.80; p < .001). Sites treated with CMX demonstrated 0.89 mm (98.3% CI: 0.49 to 1.30) more shrinkage between postop and 1 year than sites treated with CTG. In addition, CMX resulted in significantly more marginal bone loss (0.39 mm; 95% CI: 0.05 to 0.74; p = .026) than CTG. There were no significant differences between the groups in terms of patients' aesthetic satisfaction (p = .938), probing depth (p = .917), plaque (p = .354), bleeding on probing (p = .783), midfacial recession (p = .915), Pink Esthetic Score (p = .121) and Mucosal Scarring Index (p = .965). Conclusions CTG remains the gold standard to increase soft tissue thickness at implant sites. Clinicians need to outweigh the benefits of CMX against considerable resorption of the graft. This study was registered in ClinicalTrials.gov (NCT04210596).".
• 01GRXS9EEN9064P2X6V018KQ8N abstract "AimTo answer the following PICOS question: "In patients with peri-implantitis, what is the efficacy of surgical therapy with adjunctive systemic or local antimicrobials, in comparison with surgical therapy alone, in terms of pocket probing depth reduction, as assessed in randomized controlled trials (RCTs) with at least 6 months of follow-up?" Materials and MethodsA systematic literature search was conducted. Reduction in mean probing pocket depth (PPD) was the primary outcome. Secondary clinical outcomes were changes in suppuration (%), changes in bleeding on probing (BOP) (%), marginal bone level changes (mm), disease resolution (%), and implant/prosthesis loss (%). Patient-reported outcome measures, possible adverse effects, and oral-health-related quality of life were also extracted if such data were available. ResultsFour RCTs assessing the use of locally (two RCTs) and systemically (two RCTs) administered antimicrobial adjuncts to surgical treatment of peri-implantitis, with 6-36-month follow-up, were included. Because of the substantial heterogeneity of interventions between the studies, meta-analysis could not be performed. A reduction in the mean PPD was observed following all the involved surgical treatments, irrespective of the addition of antimicrobials. Except for the effect of systemic antimicrobials on marginal bone level changes and local antimicrobials on BOP, the effect of systemic and local antimicrobials was equivocal for all secondary outcome measures. ConclusionsBased on the limited available evidence, the adjunctive use of the currently tested systemic or local antimicrobials during surgical therapy, in comparison with surgical therapy alone, in patients with peri-implantitis does not seem to improve the clinical efficacy. With regard the use of systemic antimicrobials, only 50% of the cases showed disease resolution after 1 year. There is a lack of studies that consider the sole use of local antimicrobials. Therefore, their true effect remains unclear.".
• 01GRXVC6K51RH3BV88FPBZ2AHK abstract "This work introduces BioLORD, a new pre-training strategy for producing meaningful representations for clinical sentences and biomedical concepts. State-of-the-art methodologies operate by maximizing the similarity in representation of names referring to the same concept, and preventing collapse through contrastive learning. However, because biomedical names are not always self-explanatory, it sometimes results in non-semantic representations. BioLORD overcomes this issue by grounding its concept representations using definitions, as well as short descriptions derived from a multi-relational knowledge graph consisting of biomedical ontologies. Thanks to this grounding, our model produces more semantic concept representations that match more closely the hierarchical structure of ontologies. BioLORD establishes a new state of the art for text similarity on both clinical sentences (MedSTS) and biomedical concepts (MayoSRS).".
• 01GRXX3EWFVKNRM9CP28RJQ3KP abstract "This paper aims to explore the all-pervasiveness of the technique of ekphrasis within Edoardo Sanguineti’s poetry, from Laborintus (1956) to Varie ed eventuali (2010). The study is conducted looking at six exemplary texts (Laborintus 3 and 7, Reisebilder 14, Cataletto 1, Corollario 43, Mantova 15) belonging to different periods of Sanguineti’s literary career and comparing them with the visual objects that they describe. In this way, the study tries to show the usage of ekphrasis not only as a simple rhetorical device but also as a primary poetical tool. Finally, the article drafts some future ways for further investigation, such as the cataloguing of all the ekphrasises hidden in Edoardo Sanguineti’s poetry, the application of the theoretical results achieved by the international visual studies, and the possibility of connecting Sanguineti’s ekphrasis with the ones used by other Italian contemporary poets.".
• 01GRXX91XK48FNJ0WEWTTK0XZ0 abstract " Gabriele d’Annunzio was frequently excluded from the generative matrix of the Italian poetical twentieth century. It is time to restore the truth free of any ideological biases. In order to do that, it is necessary to retrace the studies conducted by d’Annunzio’s successors who tried to explore different ways to reckon with his work. Studies of that kind would make it possible to hypothesise a methodology to use for a systematic investigation aimed at revealing the entity of the qualitative and quantitative impact d’Annunzio’s work has had on much of the Italian poetry. It would subsequently be possible to draft a rough analytic route to use as starting point for more substantial future investigations.".
• 01GRY2EYW560GFP9EA1E2RYZ61 abstract "The current study evaluated the feasibility and preliminary clinical impact of robot-led distraction during needle procedures in children with chronic diseases on pain-related memories. Participants were 22 children (8-12 years old) diagnosed with a chronic disease (e.g., chronic immune deficiency) and undergoing a needle procedure as part of their routine treatment. Children were randomized to the experimental group (i.e., robot-led distraction) or control group (i.e., usual care). For feasibility, we evaluated study- and needle-procedure-related characteristics, intervention fidelity and acceptability, and nurse perceptions of the intervention. Primary clinical outcomes included children's memory bias for pain intensity and pain-related fear (1 week later). Results indicated that intervention components were >90% successful. Overall, the robot-led distraction intervention was perceived highly acceptable by the children, while nurse perceptions were mixed, indicating several challenges regarding the intervention. Preliminary between-group analyses indicated a medium effect size on memory bias for pain intensity (Hedges' g = 0.70), but only a very small effect size on memory bias for pain-related fear (Hedges' g = 0.09), in favor of the robot-led distraction intervention. To summarize, while feasible, certain challenges remain to clinically implement robot-led distraction during needle procedures. Further development of the intervention while accounting for individual child preferences is recommended.".
• 01GRYGDEJQH21NWEJYYRG96T2V abstract "Titanium dioxide (TiO2) exhibits exceptional properties such as a rapid electron transport, high dielectric constant, wide band gap, high refractive index, and large birefringence. Further, it is a photocatalyst and highly biocompatible. It is widely implemented in electronic and photonic applications like solar cells, sensors, transistors, memory devices, and force transducers. However, its use at the nanoscale has been limited by challenges in fabrication. The most common bottom-up fabrication methods lack fine dimensional control and structural uniformity. To overcome these limitations, plasma etching-based top-down fabrication is preferred in general but TiO2 suffers from the difficulty in etching [1]. To address this challenge, we have developed a novel fabrication method utilizing fluorine-based dry etching to controllably fabricate TiO2 nanostructures, and chemically modify their surfaces employing readily accessible surface functionalization methods. In our fabrication protocol (Fig 1), a chromium (Cr) etch mask provides increased resistance to dry etching and allows a wider range of aspect ratios and sidewall angles through its high etch selectivity. The patterning process using electron-beam (e-beam) lithography allows high dimensional uniformity of nanostructures. Additionally, free nanoparticles can be generated from them through mechanical cleaving (Fig 1f, Fig 2). We have optimized TiO2 etching parameters for two types of fluorine-based plasma etching configurations. First, for the trifluoromethane (CHF3)-based plasma etching of TiO2 with a reactive ion etching (RIE) machine, we obtain high etch selectivity (~15:1) as well as controlled sidewall angles. Depending on the amount of added oxygen (O2) gas flow, the angles can be varied from positive to negative, including vertical sidewalls (Fig 3a). Interestingly, with higher O2 gas flow, the fabrication of hourglass-shaped nanocylinders is also possible (Fig 3b). Second, we also optimize the sulfur hexafluoride (SF6)-based plasma etching of TiO2 with an inductively coupled plasma (ICP)-RIE machine. It allows us to achieve higher etch rates of 100-200 nm/min, compared to those of 30-50 nm/min in CHF3-based RIE, possibly due to high ion density and less passivation. Increasing ICP power, hence providing higher ion density, results in more positive sidewall angles (Fig 3c) due to more rapid Cr mask etch rates which reduce etch selectivity. On the other hand, with a reduced ICP power, we can fabricate nanocylinders with nearly vertical sidewalls (Fig 3d), demonstrating sufficient etch selectivity (~12:1). As we use the rutile-phase TiO2 that is the most difficult to etch [2], our method is expected to be directly applicable to the other phases with only minor modifications of a few etching parameters. For surface functionalization of TiO2 surfaces, we utilize widely used epoxysilanes as surface linker molecule (Fig 4a) [3]. The dense, homogeneous surface coating is demonstrated by attaching fluorophores to the epoxysilane-coated surface and imaging their fluorescence emission (Fig 4b). Moreover, the functionalization can be selectively performed only on top of nanocylinders (Fig 4c) with partial PMMA coating (Fig 1e). The introduced fabrication and functionalization methods can be employed in diverse applications that exploit the unique physical and chemical properties of TiO2 at the nanoscale, including biomolecular sensing.".
• 01GRZHDNX1F3WM193KDVHKYB4K abstract "An ideal audio retrieval system efficiently and robustly recognizes a short query snippet from an extensive database. However, the performance of well-known audio fingerprinting systems falls short at high signal distortion levels. This paper presents an audio retrieval system that generates noise and reverberation robust audio fingerprints using the contrastive learning framework. Using these fingerprints, the method performs a comprehensive search to identify the query audio and precisely estimate its timestamp in the reference audio. Our framework involves training a CNN to maximize the similarity between pairs of embeddings extracted from clean audio and its corresponding distorted and time-shifted version. We employ a channel-wise spectral-temporal attention mechanism to better discriminate the audio by giving more weight to the salient spectral-temporal patches in the signal. Experimental results indicate that our system is efficient in computation and memory usage while being more accurate, particularly at higher distortion levels, than competing state-of-the-art systems and scalable to a larger database.".
• 01GS008BS762NKMZ92Q8CMSG7T abstract "Fretting fatigue has a wide range of applications in many fields, which have high requirements for accurate prediction of their lifetime. In this paper, the theory of critical distance using volume method and mesh control approach are applied to predict the fretting fatigue lifetime. Considering the existence of heterogeneity and defects in the material, the homogenization method and sub-model technique is used to directly investigate the influence of defects on stress, strain and fatigue lifetime. It is found that the computational cost can be reduced dramatically due to the use of mesh control approach. The prediction accuracy is improved through the implementation of the Unit Cell (UC) models based on a sub-modelling technique. Meanwhile, the Representative Volume Element (RVE) is applied for the estimations of fretting fatigue lifetimes using homogenization method taking into account the heterogeneity of material.".
• 01GS00PGYQT1P8VQARS5HEWS2P abstract "The current study empirically investigates patient agency as a multi-layered and dynamic construct. We explored how agency appears before, during and after 20 sessions of psychodynamic therapy. Building on the Listening Guide, we examined interviews with a woman who had depressive complaints, paying attention to the main plot lines, associative logic and musicality in speech. As a result, we constructed four voices (i.e., ‘the caregiver’s voice’, ‘the silent dictator’, ‘the inexplicable’, and ‘encouragement and doubt, fright and relief’) that shifted dynamically throughout the interviews. Each voice follows an idiosyncratic logic when it comes to agency. We interpreted the results building on psychoanalytic theory and the postmodern story notion and nuanced the concept of agency as implying both a subjective component that creates room for change and an egoic component that has a certain inertia and sustains the illusion of mastery".
• 01GS1539J2SKBHCDTSB7WK07SD abstract "Background It is important to understand the effects of population ageing on disease burden and explore conditions that drive poor health in later life to prevent or manage these. We examined the development of disease burden and its components for major disease groups among older adults in Europe over the last 30 years. Methods Using data from the Global Burden of Disease 2019 Study, we analyzed burden of disease trends between 1990 and 2019 measured by years of life lost (YLL), years lived with disability (YLD) and disability-adjusted life years (DALYs) among older adults (65+ years) in Western, Central and Eastern Europe using cause groups for diseases and injuries. Results Between 1990 and 2019, the crude numbers of DALYs for all causes increased substantially among older Western Europeans. In Eastern Europe, the absolute DALYs also increased from 1990 to 2005 but then decreased between 2006 and 2013. However, DALY rates declined for all European regions over time, with large differences in the magnitude by region and gender. Changes in the YLL rate were mainly driven by the contribution of cardiovascular diseases. Conclusions This study found an increased overall absolute disease burden among older Europeans between 1990 and 2019. The demographic change that has taken place in Eastern European countries implies a potential problem of directed resource allocation to the health care sector. Furthermore, the findings highlight the potential health gains through directing resources to health promotion and treatment to reduce YLDs and to prevent YLLs, primarily from cardiovascular diseases.".
• 01GS15403WA3XF008Q8YXJEQ0T abstract "Purpose: The purpose of this study was to examine the nature of speech disfluencies in autistic young adults and controls by using a wide-range disfluency classification of typical disfluencies (TD; i.e., filled pauses, revisions, abandoned utterances, and multisyllable word and phrase repetitions), stuttering-like disfluencies (SLD; i.e., sound and syllable repetitions, monosyllable word repetitions, prolongations, blocks, and broken words), and atypical disfluencies (AD; i.e., word-final prolongations and repetitions and atypical insertions). Method: Thirty-two autistic young adults and 35 controls completed a narrative telling task based on socially complex events. Frequencies of total disfluencies, TD, SLD, AD and stuttering severity were compared between groups. Results: The overall frequency of disfluencies was significantly higher in the autistic group and significant between-group differences were found for all disfluency categories. The autistic group produced significantly more revisions, filled pauses, and abandoned utterances, and each subtype of SLD and AD than the control group. In total, approximately every fourth autistic participants scored at least a very mild severity of stuttering, and every fifth produced more than three SLD per 100 syllables. Conclusions: Disfluent speech can be challenging for effective communication. This study revealed that the speech of autistic young adults was highly more disfluent than that of the controls. The findings provide information on speech disfluency characteristics in autistic young adults and highlight the importance of evaluating speech disfluency with a wide-range disfluency classification in autistic persons in order to understand their role in overall communication. The results of this study offer tools for SLPs to evaluate and understand the nature of disfluencies in autistic persons.".
• 01GS1587CDX72XH3Q8GT5A1CPC abstract " This systematic literature review aimed to provide an overview of the characteristics and methods used in studies applying the disability-adjusted life years (DALY) concept for infectious diseases within European Union (EU)/European Economic Area (EEA)/European Free Trade Association (EFTA) countries and the United Kingdom. Electronic databases and grey literature were searched for articles reporting the assessment of DALY and its components. We considered studies in which researchers performed DALY calculations using primary epidemiological data input sources. We screened 3053 studies of which 2948 were excluded and 105 studies met our inclusion criteria. Of these studies, 22 were multi-country and 83 were single-country studies, of which 46 were from the Netherlands. Food- and water-borne diseases were the most frequently studied infectious diseases. Between 2015 and 2022, the number of burden of infectious disease studies was 1.6 times higher compared to that published between 2000 and 2014. Almost all studies (97%) estimated DALYs based on the incidence- and pathogen-based approach and without social weighting functions; however, there was less methodological consensus with regards to the disability weights and life tables that were applied. The number of burden of infectious disease studies undertaken across Europe has increased over time. Development and use of guidelines will promote performing burden of infectious disease studies and facilitate comparability of the results.".
• 01GS2PSN69SAHSNDT57QXB91QC abstract "Although it is not a secret that the precise implications of the proportionality principle in criminal law matters are still subject to debate, up until now, this has not been perceived as problematic. However, analysis reveals that the poor framing of the proportionality principle has some extreme negative consequences in transnational (EU) settings. The vague and inconsistent interpretation of the proportionality principle could not only result in disproportionate sentences, but could also give rise to an infringement of the equality principle. This contribution aims to stress and challenge these insufficiencies of the theoretical framework by exploring the gaps that urgently need to be dealt with. Furthermore, some possible solutions are thoroughly examined.".
• 01GS2PZ8T18JHDRSVWV3JJR3SM abstract "The international validity of convictions can hardly be called a new topic, certainly not within a European Union context. Within the EU, mutual recognition of foreign convictions has been accepted as a leading principle. Therefore, it already gained considerable attention, both of the EU legislator and of legal scholars. However, analysis reveals that mutual recognition of foreign convictions has only been anchored partially in the current EU legal framework. Whereas foreign convictions are relevant in different phases of the criminal procedure, mutual recognition in one particular phase lacks adequate anchoring. The recognition of a foreign convictions has been dealt with in relation to ‘the prosecution phase’ and ‘the executing phase’, but has been largely left to Member State discretion for ‘the sentencing phase’ that comes in between those phases. As a result, some Member States have opted for sentencing laws which partially or even completely disregard the existence of relevant foreign convictions, whereas other Member States have opted for sentencing laws which – in the spirit of mutual recognition – treat foreign convictions as if it were national convictions. This contribution will argue that an infringement of the equality principle is possibly at stake – not so much between these two types of Member States, but within Member States that partially or completely disregard foreign convictions during sentencing. It does so with specific reference to the case law of both the Court of Justice of the European Union and the European Court of Human Rights.".
• 01GS2WQECJ884M7N1MNQ449041 abstract "A dataset comprising geomorphological information (side-scan sonar, bathymetry, samples, drop camera, scuba diving, and a limited number of subbottom profiles) revealed a large number of low-relief buildups occupying almost half of the Gulf of Gera, a shallow land-locked environment. They probably represent mud mounds constructed of biogenic fragments and benthic assemblages consisting mainly of mollusks in a fine-grained matrix, and they are confined to the central part of the gulf. According to their morphometric characteristics and surface distribution, the mounds were separated into three subtypes with the highest (up to 2.5 m), larger coalescing features occurring close to the gulf entrance, whereas the smaller and more circular features appear in an elongated zone at the center of the gulf. This configuration coincides with the gulf's circulation pattern that disperses and transports nutrients and fine-grained material. The high-resolution subbottom profiles, acquired in a restricted zone of the southeastern gulf, have shown the presence of paleo-mound surfaces in the Holocene highstand surface layer and fluids in the underlying sediments. Similar formations have been rarely reported in the literature, and those other reports are from different environmental settings. Consistent with the literature, they are probably developed due to the interplay of physical and biological processes. However, only an interdisciplinary study could shed light on the specific processes that drive their formation and their unique distribution pattern in the specific environment of the Gulf of Gera.".
• 01GS2X1FSEJS6W554C9S3CNPN3 abstract "We report the sediment features of the 2018 Palu tsunami in Indonesia based on the results of laboratory analysis. The mechanism for generating the 2018 Palu tsunami was a combination of an earthquake and a landslide, and several previous studies classified the tsunami as having a shorter wavelength and period. The characteristics of the deposits of tsunamis with shorter wavelengths and periods are not well recognized. We analysed samples of tsunami deposits along two transects on the east coast of Palu Bay. Grain size analysis showed that the deposits were generally fining upward along the transect, except for the seaward sites at Kayumalue. At both transects, grain sizes were mostly unimodally distributed. The organic and carbonate content in the tsunami deposits fluctuated, but in general the carbonates were higher in the tsunami deposits than in the pre-tsunami deposits. Organic matter tended to be higher in the pre-tsunami sediments. The content of geochemical elements also fluctuated. The content of foraminifera in the tsunami deposits was dominated by benthic species. The dominant sources of tsunami deposits were the transition to inner neritic zones, with minor contribution from pre-tsunami sediments. We conclude that the short-wave tsunami deposits of the Palu event are characterized by thin deposits with a dominant unimodal grain size distribution, sourced mostly from the shallow areas of Palu Bay.".
• 01GS2XAVTEE8VAHWGG60QEY7XP abstract "South-eastern Sicily is one of the most seismically active areas of the Mediterranean Sea, marked by a high level of crustal seismicity, causing major earthquakes (up to Mw similar to 7). As a consequence, this area is prone to earthquake-generated tsunamis, which affected the Ionian coast of Sicily in historical times. These tsunamis left geomorphic and sedimentary imprints, such as large boulders or high-energy deposits, along the coasts. One of these was reported by previous works along the coast of Ognina, a small residential area located 20 km south of Siracusa. The deposits fill the back edge of a ria incised into Miocene limestones, are composed of three main stratigraphic units and were attributed to several tsunami and storm events that occurred along the coasts of south-eastern Sicily since the IV century Common Era (CE). Here, we use numerical models to simulate the impact of these extreme marine events, at the time of their occurrence, along the Ognina coastal sector, with the aim to: i) better define the tsunamigenic sources responsible for the events found in the deposits, ii) verify if some units could be related to a storm event, iii) investigate constrains on the paleogeography of the studied area at the time of tsunami and storm occurrence. We reconstructed the morphology of ancient local landscapes using geological and historical information, together with a detailed topographic and geoelectrical survey. We implemented a modelling chain (composed of Delft Dashboard, Delft 3d-FLOW and XBeach) to simulate the tsunami and storm wave propagation upon the ancient landscapes. Our results demonstrate that the use of advanced modeling tools, combined with in situ geological evidence and geophysical survey, has the potential to support the attribution of coastal geomorphic imprints to specific tsunami or storm events, the better definition of the paleo-landscapes, and the identification of the most likely tsunamigenic sources. This last aspect plays a fundamental role in providing more reliable characteristics of the tsunami propagation as well as in the assessing of potential tsunami hazard and related coastal impacts.".
• 01GS2XQJ54GFGYXSD7A4R6N2QM abstract "Glacier meltwater supplies silicon (Si) and iron (Fe) sourced from weathered bedrock to downstream ecosystems. However, the extent to which these nutrients reach the ocean is regulated by the nature of the benthic cycling of dissolved Si and Fe within fjord systems, given the rapid deposition of reactive particulate fractions at fjord heads. Here, we examine the benthic cycling of the two nutrients at four Patagonian fjord heads through geochemical analyses of sediment pore waters, including Si and Fe isotopes (δ30Si and δ56Fe), and reaction-transport modeling for Si. A high diffusive flux of dissolved Fe from the fjord sediments (up to 0.02 mmol m−2 day−1) compared to open ocean sediments (typically <0.001 mmol m−2 day−1) is supported by both reductive and non-reductive dissolution of glacially-sourced reactive Fe phases, as reflected by the range of pore water δ56Fe (−2.7 to +0.8‰). In contrast, the diffusive flux of dissolved Si from the fjord sediments (0.02–0.05 mmol m−2 day−1) is relatively low (typical ocean values are >0.1 mmol m−2 day−1). High pore water δ30Si (up to +3.3‰) observed near the Fe(II)-Fe(III) redox boundary is likely associated with the removal of dissolved Si by Fe(III) mineral phases, which, together with high sedimentation rates, contribute to the low diffusive flux of Si at the sampled sites. Our results suggest that early diagenesis promotes the release of dissolved Fe, yet suppresses the release of dissolved Si at glaciated fjord heads, which has significant implications for understanding the downstream transport of these nutrients along fjord systems.".
• 01GS4RY0KK0BMSQM3C0TKTS50A abstract "Background and AimsNon-alcoholic fatty liver disease (NAFLD) is defined as fatty liver disease in the absence of heavy alcohol consumption. However, the impact of light-to-moderate alcohol consumption on progressive NAFLD and on mortality is presently unclear. MethodsMedline, Embase, OATD and OpenGrey were systematically searched up to November 2022 for relevant cross-sectional, case-control and cohort studies. The study outcomes were progressive NAFLD-steatohepatitis (NASH), fibrosis, cirrhosis, hepatocellular carcinoma (HCC) and mortality. The entire review process was performed by two independent reviewers. A narrative synthesis was performed for all outcomes, while meta-analyses, subgroup analyses and publication bias assessment were performed depending on the number of articles. ResultsAfter study selection, 32 articles were included. Cohort studies reported that moderate alcohol intake increased the risk for advanced fibrosis (pooled OR 1.56; 95% CI 1.08-2.26 and HR 1.39; 95% CI 1.22-1.57), which was not observed in cross-sectional studies. Alcohol use also increased the risk of developing liver cirrhosis and HCC, but seemed to lower the risk of steatohepatitis. Light alcohol consumption protected against all-cause mortality, an effect not observed in NAFLD patients with moderate intake. ConclusionsThere is wide heterogeneity in studies on the impact of alcohol on progressive NAFLD. Nevertheless, cohort studies reported a significant harmful effect of moderate alcohol consumption on the occurrence of advanced fibrosis. Further research is needed to make valid recommendations with regard to alcohol consumption in patients with NAFLD.".
• 01GS4V8P2RE7W2NZE29E3F5CFK abstract "To meet the increasing global demand for food, feed, fibre and other plant-derived products, a steep increase in crop productivity is a scientifically and technically challenging imperative. The CropBooster-P project, a response to the H2020 call ‘Future proofing our plants’, is developing a roadmap for plant research to improve crops critical for the future of European agriculture by increasing crop yield, nutritional quality, value for non-food applications and sustainability. However, if we want to efficiently improve crop production in Europe and prioritize methods for crop trait improvement in the coming years, we need to take into account future socio-economic, technological and global developments, including numerous policy and socio-economic challenges and constraints. Based on a wide range of possible global trends and key uncertainties, we developed four extreme future learning scenarios that depict complementary future developments. Here, we elaborate on how the scenarios could inform and direct future plant research, and we aim to highlight the crop improvement approaches that could be the most promising or appropriate within each of these four future world scenarios. Moreover, we discuss some key plant technology options that would need to be developed further to meet the needs of multiple future learning scenarios, such as improving methods for breeding and genetic engineering. In addition, other diverse platforms of food production may offer unrealized potential, such as underutilized terrestrial and aquatic species as alternative sources of nutrition and biomass production. We demonstrate that although several methods or traits could facilitate a more efficient crop production system in some of the scenarios, others may offer great potential in all four of the future learning scenarios. Altogether, this indicates that depending on which future we are heading toward, distinct plant research fields should be given priority if we are to meet our food, feed and non-food biomass production needs in the coming decades.".
• 01GS4WSP8WTF3R8GGRMF9CXTS2 abstract "Food-approved biopolymeric stabilizers that can construct stable emulsions, but destabilize on purpose using a specific stimulus like pH change would be of great importance to food and pharmaceutical industries (bioactive delivery). However, such edible stabilizers are reasonably rare, since they must possess superb interfacial activity (rapid, robust, and reversible adsorption at the oil/water interface) to be efficient in the stabilization of such unique systems. Herein, we report the formation of sodium caseinate (SC)-kappa appa-carrageenan (kC) conjugates that can offer such stabilizing ability. SC-kC conjugates were prepared by wet-heating Maillard reaction after sonication pre-treatments (400 W, 20 kHz) for 10, 20, and 30 min. The SC-kC conjugation was confirmed by Fourier transform infrared spectroscopy, CD spectra, and glycation degree (GD). With increased sonication duration, a higher GD (59.75 +/- 0.69% in 30 min) was observed, which led to an improved interfacial activity (higher adsorption quantity and rate at interface), lower particle size (< 500 nm) as well as higher emulsifying activity and stability indices. It was observed that the emulsion prepared with the 30 min ultrasonic conjugate had the lowest mean droplet size (1.65 +/- 0.10 mu m) and polydispersity index (0.46 +/- 0.00) along with the highest absolute zeta potential value (-35.76 +/- 0.54 mV). Furthermore, it was found that sonothermal glycation with kC empowered the SC to fabricate emulsions with excellent pH-responsive behaviors where it can be easily switched on (pH = 7) and off (pH = 4.5) over four cycles and remain stable with further emulsification. Therefore, unique emulsion systems with attributes desired for many applications can be fabricated by SC-kC conjugates.".
• 01GS4ZE7S71G1X4AGTZ4NE95K1 abstract "IntroductionMeasuring changes in the appropriateness of end-of-life care provided to patients with advanced illness such as cancer, COPD or dementia can help governments and practitioners improve service delivery and quality of life. However, an assessment of a possible shift in appropriateness of end-of-life care across the population is lacking. AimMeasuring quality indicators with routinely collected population-level data, this study aims to evaluate the appropriateness of end-of-life care for people with cancer, COPD or dementia in Belgium. DesignA population-level decedent cohort study, using data from eight population-level databases, including death certificate and health claims data. We measured validated sets of quality indicators for appropriateness of end-of-life care. Setting/ParticipantsAll people who died from cancer or COPD or with dementia between 1st January 2010 and 1st January 2016 in Belgium. ResultsWe identified three main trends over time across the three disease groups of increasing use of: family physicians in the last 30 days of life (+21.7% in cancer, +33.7% in COPD and +89.4% in dementia); specialist palliative care in the last 14 days of life (+4.6% in cancer, +36.9% in COPD, +17.8% in dementia); and emergency department in the last 30 days of life (+7.0% in cancer, +4.4% in COPD and +8.2% in dementia). ConclusionsAlthough we found an increase of both specialized palliative care and generalist palliative care use, we also found an increase in potentially inappropriate care, including ED and ICU admissions. To increase the quality of end-of-life care, both timely initiating (generalist and specialist) palliative care and avoiding potentially inappropriate care transitions, treatments and medications need to be quality performance targets.".
• 01GS53FSXPBZWVC28VEXB52F8G abstract "In order to develop smart laser powder bed fusion (LPBF) devices that autonomously identify a defect and remove it during the process for first-time-right and zero-defect parts, it is important to develop reliable on-machine defect measuring capabilities. As defects in LPBF parts often occur below the layer that is being processed, capturing the information of a printing layer may not give information about physical phenomena that are occurring below this layer. Therefore, to predict volumetric features such as porosity only by looking at the layer being processed, the correlation between process signatures identified in-process and defects measured via post-process inspection methods (for example X-ray computed tomography) needs to be conducted. Hence, in situ monitoring and post-process metrology form a basis to better understand the fundamental physics involved in an LPBF process and ultimately to determine its stability. By utilizing high-speed imaging, various process signatures are produced during single-track formation of 316L stainless steel with various combinations of laser power and scan speed. In this study, we evaluate whether these signatures can be used to detect the onset of potential defects. To identify process signatures, image segmentation and feature detection are applied to the monitoring data along the line scans. The process signatures determined in the current study are mainly related to the features like the process zone length-to-width ratio, process zone area, process zone mean intensity, spatter speed and number of spatters. It is shown that the scan speed has a significant impact on the process stability and spatter formation during single-track fusion. Simulations with similar processing conditions were also performed to predict melt pool geometric features. Post-process characterization techniques such as X-ray computed tomography and 2.5-D surface topography measurement were carried out for a quality check of the line track. An attempt was made to correlate physics-based features with process-related defects and a correlation between the number of keyhole porosities, and the number of spatters was observed for the line tracks.".
• 01GS543H4V1685G4NKERHH6FJT abstract "CCR5 is the main HIV co-receptor. We aimed to (1) compare CCR5 expression on immune cells between people living with HIV (PLHIV) using combination antiretroviral therapy (cART) and HIV-uninfected controls, (2) relate CCR5 expression to viral reservoir size and (3) assess determinants of CCR5 expression. This cross-sectional study included 209 PLHIV and 323 controls. Percentages of CCR5+ cells (%) and CCR5 mean fluorescence intensity assessed by flow cytometry in monocytes and lymphocyte subsets were correlated to host factors, HIV-1 cell-associated (CA)-RNA and CA-DNA, plasma inflammation markers and metabolites. Metabolic pathways were identified. PLHIV displayed higher percentages of CCR5+ monocytes and several CD8+ T cell subsets, but lower percentages of CCR5+ naive CD4+ T cells and regulatory T cells (Tregs). HIV-1 CA-DNA and CA-RNA correlated positively with percentages of CCR5+ lymphocytes. Metabolome analysis revealed three pathways involved in energy metabolism associated with percentage of CCR5+ CD8+ T cells in PLHIV. Our results indicate that CCR5 is differently expressed on various circulating immune cells in PLHIV. Hence, cell-trafficking of CD8+ T cells and Tregs may be altered in PLHIV. Associations between energy pathways and percentage of CCR5+ CD8+ T cells in PLHIV suggest higher energy demand of these cells in PLHIV.".
• 01GS546BDBZ939SQCSJ64JPQ5A abstract "ObjectivesTo investigate the value of magnetization transfer (MT) MRI and texture analysis (TA) of T2-weighted MR images (T2WI) in the assessment of intestinal fibrosis in a mouse model.MethodsChronic colitis was induced in mice by cyclic administration of dextran sodium sulphate (DSS) resulting in chronic inflammation and progressive bowel fibrosis. Mice underwent 7-T MR imaging at various time points. Bowel wall MT ratio (MTR) and textural features (skewness, kurtosis, entropy), extracted by a filtration histogram technique, were correlated with histopathology. Performance of both techniques were validated using antifibrotic therapy. Finally, a retrospective study was conducted in five patients with Crohn's disease (CD) who underwent bowel surgery.ResultsMTR and texture entropy correlated with histopathological fibrosis (r = .85 and .81, respectively). Entropy was superior to MTR for monitoring bowel fibrosis in the presence of coexisting inflammation (linear regression R-2 = .93 versus R-2 = .01). Furthermore, texture entropy was able to assess antifibrotic therapy response (placebo mice versus treated mice at endpoint scan; Delta mean = 0.128, p < .0001). An increase in entropy was indicative of fibrosis accumulation in human CD strictures (inflammation: 1.29; mixed strictures: 1.4 and 1.48; fibrosis: 1.73 and 1.9).ConclusionMT imaging and TA of T2WI can both noninvasively detect established intestinal fibrosis in a mouse model. However, TA is especially useful for the longitudinal quantification of fibrosis in mixed inflammatory-fibrotic tissue, as well as for antifibrotic treatment response evaluation. This accessible post-processing technique merits further validation as the benefits for clinical practice as well as antifibrotic trial design would be numerous.".
• 01GS546VHYFRCPR631K1S16AEW abstract "Simple Summary The current routine treatment for glioblastoma (GB), the most lethal high-grade brain tumor in adults, aims to induce DNA damage in the tumor. However, the tumor cells might be able to repair that damage, which leads to therapy resistance. Fortunately, DNA repair defects are common in GB cells, and their survival is often based on a sole backup repair pathway. Hence, targeted drugs inhibiting essential proteins of the DNA damage response have gained momentum and are being introduced in the clinic. This review gives a perspective on the use of radiopharmaceuticals targeting DDR kinases for imaging in order to determine the DNA repair phenotype of GB, as well as for effective radionuclide therapy. Finally, four new promising radiopharmaceuticals are suggested with the potential to lead to a more personalized GB therapy. Despite numerous innovative treatment strategies, the treatment of glioblastoma (GB) remains challenging. With the current state-of-the-art therapy, most GB patients succumb after about a year. In the evolution of personalized medicine, targeted radionuclide therapy (TRT) is gaining momentum, for example, to stratify patients based on specific biomarkers. One of these biomarkers is deficiencies in DNA damage repair (DDR), which give rise to genomic instability and cancer initiation. However, these deficiencies also provide targets to specifically kill cancer cells following the synthetic lethality principle. This led to the increased interest in targeted drugs that inhibit essential DDR kinases (DDRi), of which multiple are undergoing clinical validation. In this review, the current status of DDRi for the treatment of GB is given for selected targets: ATM/ATR, CHK1/2, DNA-PK, and PARP. Furthermore, this review provides a perspective on the use of radiopharmaceuticals targeting these DDR kinases to (1) evaluate the DNA repair phenotype of GB before treatment decisions are made and (2) induce DNA damage via TRT. Finally, by applying in-house selection criteria and analyzing the structural characteristics of the DDRi, four drugs with the potential to become new therapeutic GB radiopharmaceuticals are suggested.".
• 01GS54ATVFBEX73SDY0236Z5KA abstract "BackgroundBefore April 2022, monkeypox virus infection in humans was seldom reported outside African regions where it is endemic. Currently, cases are occurring worldwide. Transmission, risk factors, clinical presentation, and outcomes of infection are poorly defined. MethodsWe formed an international collaborative group of clinicians who contributed to an international case series to describe the presentation, clinical course, and outcomes of polymerase-chain-reaction-confirmed monkeypox virus infections. ResultsWe report 528 infections diagnosed between April 27 and June 24, 2022, at 43 sites in 16 countries. Overall, 98% of the persons with infection were gay or bisexual men, 75% were White, and 41% had human immunodeficiency virus infection; the median age was 38 years. Transmission was suspected to have occurred through sexual activity in 95% of the persons with infection. In this case series, 95% of the persons presented with a rash (with 64% having <10 lesions), 73% had anogenital lesions, and 41% had mucosal lesions (with 54 having a single genital lesion). Common systemic features preceding the rash included fever (62%), lethargy (41%), myalgia (31%), and headache (27%); lymphadenopathy was also common (reported in 56%). Concomitant sexually transmitted infections were reported in 109 of 377 persons (29%) who were tested. Among the 23 persons with a clear exposure history, the median incubation period was 7 days (range, 3 to 20). Monkeypox virus DNA was detected in 29 of the 32 persons in whom seminal fluid was analyzed. Antiviral treatment was given to 5% of the persons overall, and 70 (13%) were hospitalized; the reasons for hospitalization were pain management, mostly for severe anorectal pain (21 persons); soft-tissue superinfection (18); pharyngitis limiting oral intake (5); eye lesions (2); acute kidney injury (2); myocarditis (2); and infection-control purposes (13). No deaths were reported. ConclusionsIn this case series, monkeypox manifested with a variety of dermatologic and systemic clinical findings. The simultaneous identification of cases outside areas where monkeypox has traditionally been endemic highlights the need for rapid identification and diagnosis of cases to contain further community spread. Clinical Features of Monkeypox in HumansIn this report, 528 cases of monkeypox across 16 countries are described. Rash, mucosal lesions, fever, lethargy, and lymphadenopathy were common clinical findings. Few patients were hospitalized.".
• 01GS54HPV6PTBSBN2JEX1S7NCN abstract "Self-amplifying RNA vaccines may induce equivalent or more potent immune responses at lower doses compared to non -repli-cating mRNA vaccines via amplified antigen expression. In this paper, we demonstrate that 1mg of an LNP-formulated dual -antigen self-amplifying RNA vaccine (ZIP1642), encoding both the S-RBD and N antigen, elicits considerably higher neutral-izing antibody titers against Wuhan-like Beta B.1.351 and Delta B.1.617.2 SARS-CoV-2 variants compared to those of convales-cent patients. In addition, ZIP1642 vaccination in mice expanded both S-and N-specific CD3+CD4+ and CD3+CD8+ T cells and caused a Th1 shifted cytokine response. We demon-strate that the induction of such dual antigen-targeted cell -medi-ated immune response may provide better protection against variants displaying highly mutated Spike proteins, as infectious viral loads of both Wuhan-like and Beta variants were decreased after challenge of ZIP1642 vaccinated hamsters. Supported by these results, we encourage redirecting focus toward the induc-tion of multiple antigen-targeted cell-mediated immunity in addition to neutralizing antibody responses to bypass waning antibody responses and attenuate infectious breakthrough and disease severity of future SARS-CoV-2 variants.".
• 01GS54PRYX1JVA6KRYTX6T9DYZ abstract "Using concentration-time data from the NEAT001/ARNS143 study (single sample at week 4 and 24), we determined raltegravir pharmacokinetic parameters using nonlinear mixed effects modelling (NONMEM v.7.3; 602 samples from 349 patients) and investigated the influence of demographics and SNPs (SLC22A6 and UGT1A1) on raltegravir pharmacokinetics and pharmacodynamics. Demographics and SNPs did not influence raltegravir pharmacokinetics and no significant pharmacokinetic/pharmacodynamic relationships were observed. At week 96, UGT1A1*28/*28 was associated with lower virological failure (p = 0.012), even after adjusting for baseline CD4 count (p = 0.048), but not when adjusted for baseline HIV-1 viral load (p = 0.082) or both (p = 0.089). This is the first study to our knowledge to assess the influence of SNPs on raltegravir pharmacodynamics. The lack of a pharmacokinetic/pharmacodynamic relationship is potentially an artefact of raltegravir's characteristic high inter and intra-patient variability and also suggesting single time point sampling schedules are inadequate to thoroughly assess the influence of SNPs on raltegravir pharmacokinetics.".
• 01GS54ZR612NJP21RB7F63AQHA abstract "GM-CSF promotes myelopoiesis and inflammation, and GM-CSF blockade is being evaluated as a treatment for COVID-19-associated hyperinflammation. Alveolar GM-CSF is, however, required for monocytes to differentiate into alveolar macrophages (AMs) that control alveolar homeostasis. By mapping cross-species AM development to clinical lung samples, we discovered that COVID-19 is marked by defective GM-CSF-dependent AM instruction and accumulation of pro-inflammatory macrophages. In a multi-center, open-label RCT in 81 non-ventilated COVID-19 patients with respiratory failure, we found that inhalation of rhu-GM-CSF did not improve mean oxygenation parameters compared with standard treatment. However, more patients on GM-CSF had a clinical response, and GM-CSF inhalation induced higher numbers of virus-specific CD8 effector lymphocytes and class-switched B cells, without exacerbating systemic hyperinflammation. This translational proof-of-concept study provides a rationale for further testing of inhaled GM-CSF as a non-invasive treatment to improve alveolar gas exchange and simultaneously boost antiviral immunity in COVID-19. This study is registered at ClinicalTrials.gov (NCT04326920) and EudraCT (2020-001254-22).".
• 01GS54ZWGJXYZYW9Q6DAQ529YM abstract "The objective of this study was to retrospectively evaluate preoperative imaging modalities for localization of parathyroid adenomas with a view to enable minimally invasive parathyroidectomy and in particular, to consider the contribution of F-18-fluorocholine-PET/CT. 104 patients with primary hyperparathyroidism, who underwent parathyroid surgery in a single centre during a 6-year period were included. Of these, 103 underwent ultrasound, 97 Tc-99m-Pertechnetate/SestaMIBI-SPECT, 20 MRI and 30 F-18-fluorocholine-PET/CT. Based on surgical findings, sensitivities and specificities for correct lateralisation in orthotopic locations were: for ultrasound 0.75 (0.65-0.83) and 0.89 (0.81-0.94), for Tc-99m-MIBI-SPECT 0.57 (0.46-0.67) and 0.97 (0.91-0.99), for MRI 0.60 (0.36-0.81) and 0.83 (0.59-0.96) and for F-18-fluorocholine-PET/CT 0.90 (0.73-0.98) and 0.90 (0.73-0.98). Correctly lateralized adenomas were significantly larger than those not found with ultrasound (p = 0.03) and SPECT (p = 0.002). Pre-operative PTH-levels were higher in single adenomas detected by scintigraphy than in those not (p = 0.02). 64 patients could be treated with a minimally invasive procedure. Cure after parathyroidectomy was obtained in 94% of patients. F-18-Fluorocholine-PET/CT could be shown to be a highly accurate modality to localize parathyroid adenomas preoperatively, obviating the need for total exploration in the majority of patients in whom ultrasound and scintigraphic results are discordant or both negative.".
• 01GS551VA5TGVQM69BWW0QF70R abstract "Lately, the interest in long non-coding RNAs (lncRNAs) as potential drug targets and predictive markers in the context of HIV-1 has peaked, but their in vivo expression and regulation remains largely unexplored. Therefore, the present study examined lncRNA expression patterns during a clinical antiretroviral treatment interruption (ATI) trial. Peripheral blood mononuclear cells were isolated from ten patients at four timepoints: prior to ATI, 7-15 days after stop, at viral rebound and 3 months post antiretroviral therapy re-initiation. RNA was extracted and RT-qPCR on five known HIV-1-related lncRNAs (HEAL, MALAT1, NEAT1, GAS5 and NRON) was performed and correlated with HIV-1 and host marker expression. All lncRNAs correlated stronger with interferon stimulated genes (ISGs) than with HIV-1 reservoir and replication markers. However, one lncRNA, HEAL, showed significant upregulation at viral rebound during ATI compared to baseline and re-initiation of therapy (p = 0.0010 and p = 0.0094, respectively), following a similar viral-load-driven expression pattern to ISGs. In vitro knockdown of HEAL caused a significant reduction in HIV-1 infection levels, validating HEAL's importance for HIV-1 replication. We conclude that the HIV-1-promoting lncRNA HEAL is upregulated at viral rebound during ATI, most likely induced by viral cues.".
• 01GS556BV955QMM4ZEPX6PA8TB abstract "PurposeTo investigate the short-term cerebral metabolic effects of intravenous chemotherapy and their association with long-term fatigue/cognitive complaints. Experimental designUsing [F-18]-FDG-PET/CT whole-body scans, we retrospectively quantified relative cerebral glucose metabolism before and after neoadjuvant chemotherapy in a cohort of patients treated for non-metastatic breast cancer (2009-2019). Self-report of cognitive complaints and fatigue were prospectively assessed 7 +/- 3 years after therapy. Metabolic changes were estimated with i) robust mixed-effects modelling in regions-of-interest (frontal, parietal, temporal, occipital, and insular cortex) and ii) general-linear modelling of whole-brain voxel-wise outcomes. iii) The association between metabolic changes and self-reported outcomes was evaluated using linear regression-analysis. ResultsOf the 667 screened patients, 263 underwent PET/CT before and after chemotherapy and 183 (48 +/- 9 years) met the inclusion criteria. After chemotherapy, decreased frontal and increased parietal and insular metabolism were observed (|ss|>0.273, p(FDR)<0.008). Separately, additional increased occipital metabolism after epiribucin+ cyclophosphamide (EC) and temporal metabolism after EC+ fluorouracil chemotherapy were observed (ss>0.244, p(FDR)<= 0.048). Voxel-based analysis (p(cluster-FWE)<0.001) showed decreased metabolism in the paracingulate gyrus (-3.2 +/- 3.9%) and putamen (3.1 +/- 4.1%) and increased metabolism in the lateral cortex (L=2.9 +/- 3.1%) and pericentral gyri (3.0 +/- 4.4%). Except for the central sulcus, the same regions showed changes in EC, but not in FEC patients. Of the 97 self-reported responders, 23% and 27% experienced extreme fatigue and long-term cognitive complaints, respectively, which were not associated with metabolic changes. ConclusionBoth hyper- and hypometabolism were observed after chemotherapy for breast cancer. Combined with earlier findings, this study could support inflammatory mechanisms resulting in relative hypermetabolism, mainly in the parietal/occipital cortices. As early metabolic changes did not precede long-term complaints, further research is necessary to identify vulnerable patients.".
• 01GS55EFTCE84PG1MNA88JKB45 abstract "Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder involving loss of upper and lower motor neurons, with most cases ending in death within 3-5 years of onset. Several molecular and cellular pathways have been identified to cause ALS; however, treatments to stop or reverse disease progression are yet to be found. Riluzole, a neuroprotective agent offering only a modest survival benefit, has long been the sole disease-modifying therapy for ALS. Edaravone, which demonstrated statistically significant slowing of ALS disease progression, is gaining approval in an increasing number of countries since its first approval in 2015. Sodium phenylbutyrate and taurursodiol (PB-TURSO) was conditionally approved in Canada in 2022, having shown significant slowing of disease progression and prolonged survival. Most clinical trials have focused on testing small molecules affecting common cellular pathways in ALS: targeting glutamatergic, apoptotic, inflammatory, and oxidative stress mechanisms among others. More recently, clinical trials utilizing stem cell transplantation and other biologics have emerged. This rich and ever-growing pipeline of investigational products, along with innovative clinical trial designs, collaborative trial networks, and an engaged ALS community', provide renewed hope to finding a cure for ALS. This article reviews existing ALS therapies and the current clinical drug development pipeline.".
• 01GS56988G0PJJJC4QK8Q60QEG abstract "With the pervasiveness and ubiquitous distribution of the magnetic field in indoor environments, indoor localization using magnetic positioning (MP) has attracted considerable attention. This work concentrates on the MP and pedestrian dead reckoning (PDR) method, and constructs a fusion system for smartphones using MP and PDR based on the extended Kalman filter (EKF). The mind evolutionary algorithm (MEA) is introduced to search for the optimal magnetic position based on a heuristic searching strategy, which uses the similartaxis and dissimilation for the evolutionary operation. In the PDR module, the acceleration characteristics of different walking patterns are analyzed and the corresponding features are extracted. The enhanced genetic algorithm-based extreme learning machine (EGA-ELM) is adopted to train these features and address the gait recognition problem of different walking patterns. Finally, to obtain a lightweight and high-precision fusion method, MEA-based MP is integrated with PDR based on the EKF. Extensive experiments are conducted to evaluate the proposed methods. The testing results showed that MEA-based MP can obtain a location error within 2.3 m and steps can be recognized with a mean accuracy of 95% when different users participate in testing. The positioning results after fusion with PDR reveal that the mean location error and root-mean-square error (RMSE) are 1.25 m and 1.53 m respectively, which outperforms the MP, PDR, MP and PDR fusion methods using improved particle filter (IPF) and genetic particle filter (GPF).".
• 01GS56FJPQ5Z4E430SJ9YZ9PMS abstract "While the motives behind municipalities’ choices of service delivery modes may lie in the past, current research still pays little attention to history. Applied to the service delivery of two waste services in nine municipalities over the period 1962–2021, this study aims to overcome this limitation by bringing in historical institutionalism. Based on the analysis of a database covering 5,229 government documents and 30 semi-structured interviews, we show that past choices structure future choices by creating juridical and economic lock-ins. Path-dependent processes overrule other potential sources of change in choices, resulting in a high degree of stability of choices.".

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