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- 01H6XKZFKFT5PY2AMHJ73FYK5G classification A1.
- 01H6XKZFKFT5PY2AMHJ73FYK5G date "2020".
- 01H6XKZFKFT5PY2AMHJ73FYK5G language "eng".
- 01H6XKZFKFT5PY2AMHJ73FYK5G type journalArticle.
- 01H6XKZFKFT5PY2AMHJ73FYK5G hasPart 01H6XM0AVSHC4EJPBXH9VR9PHX.pdf.
- 01H6XKZFKFT5PY2AMHJ73FYK5G subject "Chemistry".
- 01H6XKZFKFT5PY2AMHJ73FYK5G doi "10.3390/ijms21124522".
- 01H6XKZFKFT5PY2AMHJ73FYK5G issn "1422-0067".
- 01H6XKZFKFT5PY2AMHJ73FYK5G issue "12".
- 01H6XKZFKFT5PY2AMHJ73FYK5G volume "21".
- 01H6XKZFKFT5PY2AMHJ73FYK5G abstract "Aptamers are short single stranded DNA or RNA oligonucleotides that can recognize analytes with extraordinary target selectivity and affinity. Despite their promising properties and diagnostic potential, the number of commercial applications remains scarce. In order to endow them with novel recognition motifs and enhanced properties, chemical modification of aptamers has been pursued. This review focuses on chemical modifications, aimed at increasing the binding affinity for the aptamer's target either in a non-covalent or covalent fashion, hereby improving their application potential in a diagnostic context. An overview of current methodologies will be given, thereby distinguishing between pre- and post-SELEX (Systematic Evolution of Ligands by Exponential Enrichment) modifications.".
- 01H6XKZFKFT5PY2AMHJ73FYK5G author 3C8B8EA0-F0EE-11E1-A9DE-61C894A0A6B4.
- 01H6XKZFKFT5PY2AMHJ73FYK5G author A8ECF9D8-07B4-11E4-B754-00CA4B2F559A.
- 01H6XKZFKFT5PY2AMHJ73FYK5G author F4BF6416-F0ED-11E1-A9DE-61C894A0A6B4.
- 01H6XKZFKFT5PY2AMHJ73FYK5G dateCreated "2023-08-03T11:54:24Z".
- 01H6XKZFKFT5PY2AMHJ73FYK5G dateModified "2024-07-09T15:58:51Z".
- 01H6XKZFKFT5PY2AMHJ73FYK5G name "Chemical modification of aptamers for increased binding affinity in diagnostic applications : current status and future prospects".
- 01H6XKZFKFT5PY2AMHJ73FYK5G pagination urn:uuid:8574ad45-5e7f-4bdf-81f5-0b086af67330.
- 01H6XKZFKFT5PY2AMHJ73FYK5G publisher urn:uuid:1d6cc712-f920-40ad-91f2-6f8e9d973f60.
- 01H6XKZFKFT5PY2AMHJ73FYK5G sameAs LU-01H6XKZFKFT5PY2AMHJ73FYK5G.
- 01H6XKZFKFT5PY2AMHJ73FYK5G sourceOrganization urn:uuid:1a9480e0-8134-4ca2-8b70-7a68725ef0dc.
- 01H6XKZFKFT5PY2AMHJ73FYK5G type A1.