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- 01JDHE8N2P1FA1D4FVXAM6VCKB classification A1.
- 01JDHE8N2P1FA1D4FVXAM6VCKB date "2024".
- 01JDHE8N2P1FA1D4FVXAM6VCKB language "eng".
- 01JDHE8N2P1FA1D4FVXAM6VCKB type journalArticle.
- 01JDHE8N2P1FA1D4FVXAM6VCKB hasPart 01JDHE96A5RYRGDSD8QQMFB8CF.pdf.
- 01JDHE8N2P1FA1D4FVXAM6VCKB subject "Technology and Engineering".
- 01JDHE8N2P1FA1D4FVXAM6VCKB subject "Veterinary Sciences".
- 01JDHE8N2P1FA1D4FVXAM6VCKB doi "10.1371/journal.pone.0309816".
- 01JDHE8N2P1FA1D4FVXAM6VCKB issn "1932-6203".
- 01JDHE8N2P1FA1D4FVXAM6VCKB issue "10".
- 01JDHE8N2P1FA1D4FVXAM6VCKB volume "19".
- 01JDHE8N2P1FA1D4FVXAM6VCKB abstract "Background Manual screening of a Kato-Katz (KK) thick stool smear remains the current standard to monitor the impact of large-scale deworming programs against soil-transmitted helminths (STHs). To improve this diagnostic standard, we recently designed an artificial intelligence based digital pathology system (AI-DP) for digital image capture and analysis of KK thick smears. Preliminary results of its diagnostic performance are encouraging, and a comprehensive evaluation of this technology as a cost-efficient end-to-end diagnostic to inform STH control programs against the target product profiles (TPP) of the World Health Organisation (WHO) is the next step for validation.Methods Here, we describe the study protocol for a comprehensive evaluation of the AI-DP based on its (i) diagnostic performance, (ii) repeatability/reproducibility, (iii) time-to-result, (iv) cost-efficiency to inform large-scale deworming programs, and (v) usability in both laboratory and field settings. For each of these five attributes, we designed separate experiments with sufficient power to verify the non-inferiority of the AI-DP (KK2.0) over the manual screening of the KK stool thick smears (KK1.0). These experiments will be conducted in two STH endemic countries with national deworming programs (Ethiopia and Uganda), focussing on school-age children only.Discussion This comprehensive study will provide the necessary data to make an evidence-based decision on whether the technology is indeed performant and a cost-efficient end-to-end diagnostic to inform large-scale deworming programs against STHs. Following the protocolized collection of high-quality data we will seek approval by WHO. Through the dissemination of our methodology and statistics, we hope to support additional developments in AI-DP technologies for other neglected tropical diseases in resource-limited settings.Trial registration The trial was registered on September 29, 2023 Clinicaltrials.gov (ID: NCT06055530).".
- 01JDHE8N2P1FA1D4FVXAM6VCKB author 19400CD2-F0EE-11E1-A9DE-61C894A0A6B4.
- 01JDHE8N2P1FA1D4FVXAM6VCKB author 329F3766-F0EE-11E1-A9DE-61C894A0A6B4.
- 01JDHE8N2P1FA1D4FVXAM6VCKB author 4a965b27-e101-11eb-addc-ace23246a5b1.
- 01JDHE8N2P1FA1D4FVXAM6VCKB author 599637c2-fde8-11ea-a1fc-fb18e55508d8.
- 01JDHE8N2P1FA1D4FVXAM6VCKB author A2897C98-290D-11E6-8F07-710BB5D1D7B1.
- 01JDHE8N2P1FA1D4FVXAM6VCKB author C94F5484-F0EE-11E1-A197-91C894A0A6B4.
- 01JDHE8N2P1FA1D4FVXAM6VCKB author F6BA63F6-F0ED-11E1-A9DE-61C894A0A6B4.
- 01JDHE8N2P1FA1D4FVXAM6VCKB author F82B56AA-F0ED-11E1-A9DE-61C894A0A6B4.
- 01JDHE8N2P1FA1D4FVXAM6VCKB author urn:uuid:76c7c966-4af4-4078-80c4-55a433809cdd.
- 01JDHE8N2P1FA1D4FVXAM6VCKB author urn:uuid:a4e14885-09d0-479d-9bea-21c7bb039ab9.
- 01JDHE8N2P1FA1D4FVXAM6VCKB author urn:uuid:abb013d4-d309-43c7-bafb-70ec1108eae0.
- 01JDHE8N2P1FA1D4FVXAM6VCKB author urn:uuid:cfe8b103-70ef-4d19-8158-a6bf46fca5b2.
- 01JDHE8N2P1FA1D4FVXAM6VCKB author urn:uuid:faa2c858-284f-40ef-b781-38ad590d9ec3.
- 01JDHE8N2P1FA1D4FVXAM6VCKB dateCreated "2024-11-25T10:35:51Z".
- 01JDHE8N2P1FA1D4FVXAM6VCKB dateModified "2024-12-12T21:14:08Z".
- 01JDHE8N2P1FA1D4FVXAM6VCKB name "A comprehensive evaluation of an artificial intelligence based digital pathology to monitor large-scale deworming programs against soil-transmitted helminths : a study protocol".
- 01JDHE8N2P1FA1D4FVXAM6VCKB pagination urn:uuid:c399b693-6ec5-4374-9ab6-b1e5f88b12ea.
- 01JDHE8N2P1FA1D4FVXAM6VCKB sameAs LU-01JDHE8N2P1FA1D4FVXAM6VCKB.
- 01JDHE8N2P1FA1D4FVXAM6VCKB sourceOrganization urn:uuid:db4ae615-d6ab-45bc-bc93-decb007a7b27.
- 01JDHE8N2P1FA1D4FVXAM6VCKB sourceOrganization urn:uuid:dc280a5c-248c-4e11-86aa-0e2e03066b78.
- 01JDHE8N2P1FA1D4FVXAM6VCKB sourceOrganization urn:uuid:dd8f1fac-d719-4382-a2a9-6496cae34c83.
- 01JDHE8N2P1FA1D4FVXAM6VCKB type A1.