Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1960374#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B227640.
- aggregation creator B227641.
- aggregation creator B227642.
- aggregation creator B227643.
- aggregation creator B227644.
- aggregation creator B227645.
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- aggregation creator B227647.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1960374.bibtex.
- aggregation hasFormat 1960374.csv.
- aggregation hasFormat 1960374.dc.
- aggregation hasFormat 1960374.didl.
- aggregation hasFormat 1960374.doc.
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- aggregation hasFormat 1960374.txt.
- aggregation hasFormat 1960374.xls.
- aggregation hasFormat 1960374.yaml.
- aggregation isPartOf urn:issn:0021-9258.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Transcription factor Zic2 inhibits Wnt/β-catenin protein signaling".
- aggregation abstract "The Zic transcription factors play critical roles during embryonic development. Mutations in the ZIC2 gene are associated with human holoprosencephaly, but the etiology is still unclear. Here, we report a novel function for ZIC2 as a regulator of beta-catenin.TCF4-mediated transcription. We show that ZIC2 can bind directly to the DNA-binding high mobility group box of TCF4 via its zinc finger domain and inhibit the transcriptional activity of the beta-catenin.TCF4 complex. However, the binding of TCF4 to DNA was not affected by ZIC2. Zic2 RNA injection completely inhibited beta-catenin-induced axis duplication in Xenopus embryos and strongly blocked the ability of beta-catenin to induce expression of known Wnt targets in animal caps. Moreover, Zic2 knockdown in transgenic Xenopus Wnt reporter embryos led to ectopic Wnt signaling activity mainly at the midbrain-hindbrain boundary. Together, our results demonstrate a previously unknown role for ZIC2 as a transcriptional regulator of the beta-catenin.TCF4 complex.".
- aggregation authorList BK497335.
- aggregation endPage "37740".
- aggregation issue "43".
- aggregation startPage "37732".
- aggregation volume "286".
- aggregation aggregates 2938139.
- aggregation isDescribedBy 1960374.
- aggregation similarTo jbc.M111.242826.
- aggregation similarTo LU-1960374.