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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 1986960.bibtex.
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- aggregation isPartOf urn:issn:1073-1199.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Decellularization of heart valve matrices: search for the ideal balance".
- aggregation abstract "Objective: Currently used decellularization procedures have negative effects on extracellular matrix (ECM) integrity. The objective of this study is to evaluate four decellularization methods and their effect on the collagen ultrastructure, mechanical behavior and antigenicity of porcine aortic valves. Methods: Aortic valves were placed in a trypsin, osmotic, trypsin-osmotic or detergent-osmotic solution. Leaflets were processed for histology and mechanical testing. Matrices were implanted subdermally in rats to evaluate immune reaction and calcification. Results: Trypsin-osmotic methodology effected near-complete decellularization. Trypsin treatment resulted in cell removal only in the spongiosa layer. Osmotic and detergent-osmotic treatments did not remove any cells from the cusps. Mechanical strength was significantly inferior in the trypsin (p = 0,03) and trypsin-osmotic treated group (p = 0,04). Trypsin and trypsin-osmotic decellularized matrices evoked a strong CD3+ inflammatory cell infiltration. Conclusion: Enzymatic-osmotic decellularization appears to be the only effective method to remove cellular components. However, the near cell free scaffolds still evokes a strong CD3+ T-cell inflammatory reaction.".
- aggregation authorList BK764056.
- aggregation endPage "162".
- aggregation issue "1-2".
- aggregation startPage "151".
- aggregation volume "40".
- aggregation aggregates 1992649.
- aggregation isDescribedBy 1986960.
- aggregation similarTo 10731199.2011.637925.
- aggregation similarTo LU-1986960.