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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
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- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 3034664.bibtex.
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- aggregation isPartOf urn:issn:1431-6730.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "A catalogue of putative HIV-1 protease host cell substrates".
- aggregation abstract "Processing of human immunodeficiency virus (HIV) proteins by the HIV-1 protease is essential for HIV infectivity. In addition, several studies have revealed cleavage of human proteins by this viral protease during infection; however, no large-scale HIV-1 protease degradomics study has yet been performed. To identify putative host substrates in an unbiased manner and on a proteome-wide scale, we used positional proteomics to identify peptides reporting protein processing by the HIV-1 protease, and a catalogue of over 120 cellular HIV-1 protease substrates processed in vitro was generated. This catalogue includes previously reported substrates as well as recently described interaction partners of HIV-1 proteins. Cleavage site alignments revealed a specificity profile in good correlation with previous studies, even though the ELLE consensus motif was not cleaved efficiently when incorporated into peptide substrates due to subsite cooperativity. Our results are further discussed in the context of HIV-1 infection and the complex substrate recognition by the viral protease.".
- aggregation authorList BK965205.
- aggregation endPage "931".
- aggregation issue "9".
- aggregation startPage "915".
- aggregation volume "393".
- aggregation aggregates 3039756.
- aggregation isDescribedBy 3034664.
- aggregation similarTo hsz-2012-0168.
- aggregation similarTo LU-3034664.