Matches in UGent Biblio for { <https://biblio.ugent.be/publication/837220#aggregation> ?p ?o. }
Showing items 1 to 45 of
45
with 100 items per page.
- aggregation classification "A1".
- aggregation creator B190603.
- aggregation creator B190604.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 837220.bibtex.
- aggregation hasFormat 837220.csv.
- aggregation hasFormat 837220.dc.
- aggregation hasFormat 837220.didl.
- aggregation hasFormat 837220.doc.
- aggregation hasFormat 837220.json.
- aggregation hasFormat 837220.mets.
- aggregation hasFormat 837220.mods.
- aggregation hasFormat 837220.rdf.
- aggregation hasFormat 837220.ris.
- aggregation hasFormat 837220.txt.
- aggregation hasFormat 837220.xls.
- aggregation hasFormat 837220.yaml.
- aggregation isPartOf urn:issn:0027-8874.
- aggregation language "eng".
- aggregation publisher "OXFORD UNIV PRESS INC".
- aggregation title "Antitumor Activity of the Selective MDM2 Antagonist Nutlin-3 Against Chemoresistant Neuroblastoma With Wild-Type p53".
- aggregation abstract "Restoring p53 function by antagonizing its interaction with the negative regulator MDM2 is an appealing nongenotoxic approach to treating tumors with wild-type p53. Mutational inactivation of p53 is rare in neuroblastoma tumors at diagnosis and occurs in only a subset of multidrug-resistant neuroblastomas. The antiproliferative and cytotoxic effect of nutlin-3, a small-molecule MDM2 antagonist, was examined in chemosensitive (UKF-NB-3) and matched chemoresistant neuroblastoma cells with wild-type p53 (UKF-NB-3(r)DOX(20)) or with mutant p53 (UKF-NB-3(r)VCR(10)). Activation of the p53 pathway was assessed by expression analysis of p53 target genes, flow cytometric cell cycle analysis, and apoptosis assays. Mice with established chemoresistant tumor xenografts were treated orally with nutlin-3 or vehicle control (n = 5-10 mice per group) and were used to evaluate effects on tumor growth, p53 pathway activity, and metastatic tumor burden. All statistical tests were two-sided. Nutlin-3 induced a similar activation of the p53 pathway in UKF-NB-3 and UKF-NB-3(r)DOX(20) cells, as evidenced by increased expression of p53 target genes, G(1) cell cycle arrest, and induction of apoptosis. No such response was observed in UKF-NB-3(r)VCR(10) cells with mutant p53. Oral administration of nutlin-3 to UKF-NB-3(r)DOX(20) xenograft-bearing mice led to inhibition of primary tumor growth (mean tumor volume after 3 weeks of treatment, nutlin-3- vs vehicle-treated mice: 772 vs 1661 mm(3), difference = 890 mm(3), 95% confidence interval = 469 to 1311 mm(3), P < .001), p53 pathway activation, and reduction in the extent of metastatic disease. The growth of UKF-NB-3(r)VCR(10) xenografts was unaffected by nutlin-3. Nutlin-3 activates the p53 pathway and suppresses tumor growth in this model system of chemoresistant neuroblastoma, provided that wild-type p53 is present.".
- aggregation authorList BK449292.
- aggregation endPage "1574".
- aggregation issue "22".
- aggregation startPage "1562".
- aggregation volume "101".
- aggregation aggregates 2937097.
- aggregation isDescribedBy 837220.
- aggregation similarTo djp355.
- aggregation similarTo LU-837220.