Matches in UGent Biblio for { <https://biblio.ugent.be/publication/847384#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B583887.
- aggregation creator B583888.
- aggregation creator B583889.
- aggregation creator B583890.
- aggregation creator B583891.
- aggregation creator B583892.
- aggregation creator B583893.
- aggregation creator person.
- aggregation date "1998".
- aggregation format "application/pdf".
- aggregation hasFormat 847384.bibtex.
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- aggregation isPartOf urn:issn:0012-1797.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor (-/-) mice".
- aggregation abstract "Incretins are gastrointestinal hormones that act on the pancreas to potentiate glucose-stimulated insulin secretion. Despite the physiological importance of the enteroinsular axis, disruption of glucagon-like peptide (GLP)-1 action is associated with only modest glucose intolerance in GLP-1 receptor -/- (GLP-1R -/-) mice. me show here that GLP-1R -/- mice exhibit compensatory changes in the enteroinsular axis via increased glucose-dependent insulinotropic polypeptide (GIP) secretion and enhanced GIP action. Serum GIP levels in GLP-1R -/- mice were significantly elevated versus those in +/+ control mice after an oral glucose tolerance test (369 +/- 40 vs. 236 +/- 28 pmol/l; P less than or equal to 0.02). Furthermore, GIP perfusion of mice pancreas and isolated islets in the presence of elevated glucose concentrations elicited a significantly greater insulin response in GLP-1R -/- than in +/+ mice (P less than or equal to 0.02-0.05). In contrast, no significant perturbation in the insulin response to perfused glucagon was detected under conditions of low (4.4 mmol/l) or high (16.6 mmol/l) glucose in GLP-1R -/- mice. Total pancreatic insulin but not glucagon content was significantly reduced in GLP-1R -/- compared with in +/+ mice (77 +/- 9 vs. 121 +/- 10 pmol/mg protein; P less than or equal to 0.005). These observations suggest that upregulation of the GIP component of the enteroinsular axis, at the levels of GLP secretion and action, modifies the phenotype resulting from interruption of the insulinotropic activity of GLP-1 in vivo.".
- aggregation authorList BK936896.
- aggregation endPage "1052".
- aggregation issue "7".
- aggregation startPage "1046".
- aggregation volume "47".
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