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- Ada_(protein) abstract "Ada, also called as O6 alkyl guanine transferase I (O6 AGT I), is an enzyme induced by treatment of bacterial cells with alkylating agents that mainly cause methylation damage. This phenomenon is called the adaptive response hence the name . Ada transfers the alkyl group from DNA bases and sugar-phosphate backbone to a cysteine residue, inactivating itself. Consequently, it reacts stoichiometrically with its substrate rather than catalytically and is referred to as a suicide enzyme. Methylation of Ada protein converts it into a self transcriptional activator, inducing its own gene expression and the expression of other genes which together with Ada help the cells repair alkylation damage. Ada removes the alkyl group attached to DNA bases like guanine (O6-alkyl guanine) or thymine (O4-alkyl thymine) and to the oxygen of the phosphodiester backbone of the DNA. However, Ada shows greater preference for O6- alkyl guanine compared to either O4-thymine and alkylated phosphotriesters. Ada enzyme has two active sites, one for the alkylated guanines and thymines and the other for alkylated phosphotriesters.".
- Ada_(protein) wikiPageID "8498347".
- Ada_(protein) wikiPageRevisionID "598156256".
- Ada_(protein) hasPhotoCollection Ada_(protein).
- Ada_(protein) subject Category:Transferases.
- Ada_(protein) type Abstraction100002137.
- Ada_(protein) type Activator114723079.
- Ada_(protein) type Catalyst114723628.
- Ada_(protein) type Chemical114806838.
- Ada_(protein) type Compound114818238.
- Ada_(protein) type Enzyme114732946.
- Ada_(protein) type Enzymes.
- Ada_(protein) type Macromolecule114944888.
- Ada_(protein) type Material114580897.
- Ada_(protein) type Matter100020827.
- Ada_(protein) type Molecule114682133.
- Ada_(protein) type OrganicCompound114727670.
- Ada_(protein) type Part113809207.
- Ada_(protein) type PhysicalEntity100001930.
- Ada_(protein) type Protein114728724.
- Ada_(protein) type Relation100031921.
- Ada_(protein) type Substance100019613.
- Ada_(protein) type Thing100002452.
- Ada_(protein) type Unit109465459.
- Ada_(protein) comment "Ada, also called as O6 alkyl guanine transferase I (O6 AGT I), is an enzyme induced by treatment of bacterial cells with alkylating agents that mainly cause methylation damage. This phenomenon is called the adaptive response hence the name . Ada transfers the alkyl group from DNA bases and sugar-phosphate backbone to a cysteine residue, inactivating itself. Consequently, it reacts stoichiometrically with its substrate rather than catalytically and is referred to as a suicide enzyme.".
- Ada_(protein) label "Ada (protein)".
- Ada_(protein) sameAs m.0275mch.
- Ada_(protein) sameAs Q4678217.
- Ada_(protein) sameAs Q4678217.
- Ada_(protein) sameAs Ada_(protein).
- Ada_(protein) wasDerivedFrom Ada_(protein)?oldid=598156256.
- Ada_(protein) isPrimaryTopicOf Ada_(protein).