Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Enalaprilat> ?p ?o. }
Showing items 1 to 54 of
54
with 100 items per page.
- Enalaprilat abstract "Enalaprilat is the active metabolite of enalapril. It is the first dicarboxylate-containing ACE inhibitor and was developed partly to overcome these limitations of captopril. The sulfhydryl-moiety was replaced by a carboxylate-moiety, but additional modifications were required in its structure-based design to achieve a similar potency to captopril.Enalaprilat, however, had a problem of its own. The consequence of the structural modifications was that it proved to have unfavourable ionisation characteristics to allow sufficient potency for oral administration (in tablets). Thus, enalaprilat was only suitable for intravenous administration. This was overcome by the esterification of enalaprilat with ethanol to produce enalapril. As a prodrug, enalapril is metabolized in vivo to the active form enalaprilat by various esterases. Peak plasma enalaprilat concentrations occur 2 to 4 hours after oral enalapril administration. Elimination thereafter is biphasic, with an initial phase which reflects renal filtration (elimination half-life 2 to 6 hours) and a subsequent prolonged phase (elimination half-life 36 hours), the latter representing equilibration of drug from tissue distribution sites. The prolonged phase does not contribute to drug accumulation on repeated administration but is thought to be of pharmacological significance in mediating drug effects. Renal impairment [particularly creatinine clearance < 20 ml/min (< 1.2 L/h)] results in significant accumulation of enalaprilat and necessitates dosage reduction. Accumulation is probably the cause of reduced elimination in healthy elderly individuals and in patients with concomitant diabetes, hypertension and heart failure.".
- Enalaprilat casNumber "76420-72-9".
- Enalaprilat chEBI "4786".
- Enalaprilat fdaUniiCode "GV0O7ES0R3".
- Enalaprilat iupacName "(2S)-1-[(2S)-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}propanoyl]pyrrolidine-2-carboxylic acid".
- Enalaprilat thumbnail Enalaprilat.svg?width=300.
- Enalaprilat wikiPageID "763967".
- Enalaprilat wikiPageRevisionID "592623059".
- Enalaprilat c "18".
- Enalaprilat casNumber "76420".
- Enalaprilat chebi "4786".
- Enalaprilat chembl "577".
- Enalaprilat chemspiderid "4575429".
- Enalaprilat h "24".
- Enalaprilat hasPhotoCollection Enalaprilat.
- Enalaprilat imagename "Enalaprilat".
- Enalaprilat inchi "1".
- Enalaprilat inchikey "LZFZMUMEGBBDTC-QEJZJMRPBX".
- Enalaprilat iupacName "-1".
- Enalaprilat licenceUs "Enalaprilat".
- Enalaprilat molecularWeight "348.4".
- Enalaprilat n "2".
- Enalaprilat o "5".
- Enalaprilat smiles "C[C@H]CN2CCC[C@H]2CO".
- Enalaprilat stdinchi "1".
- Enalaprilat stdinchikey "LZFZMUMEGBBDTC-QEJZJMRPSA-N".
- Enalaprilat unii "GV0O7ES0R3".
- Enalaprilat width "200".
- Enalaprilat subject Category:ACE_inhibitors.
- Enalaprilat subject Category:Dicarboxylic_acids.
- Enalaprilat subject Category:Pyrrolidines.
- Enalaprilat type Abstraction100002137.
- Enalaprilat type Acid114607521.
- Enalaprilat type Chemical114806838.
- Enalaprilat type Compound114818238.
- Enalaprilat type DicarboxylicAcids.
- Enalaprilat type Material114580897.
- Enalaprilat type Matter100020827.
- Enalaprilat type Part113809207.
- Enalaprilat type PhysicalEntity100001930.
- Enalaprilat type Relation100031921.
- Enalaprilat type Substance100019613.
- Enalaprilat type Drug.
- Enalaprilat type FunctionalSubstance.
- Enalaprilat comment "Enalaprilat is the active metabolite of enalapril. It is the first dicarboxylate-containing ACE inhibitor and was developed partly to overcome these limitations of captopril. The sulfhydryl-moiety was replaced by a carboxylate-moiety, but additional modifications were required in its structure-based design to achieve a similar potency to captopril.Enalaprilat, however, had a problem of its own.".
- Enalaprilat label "Enalaprilat".
- Enalaprilat sameAs m.0gfdnjk.
- Enalaprilat sameAs Q5375179.
- Enalaprilat sameAs Q5375179.
- Enalaprilat sameAs enalaprilat.
- Enalaprilat sameAs Enalaprilat.
- Enalaprilat wasDerivedFrom Enalaprilat?oldid=592623059.
- Enalaprilat depiction Enalaprilat.svg.
- Enalaprilat isPrimaryTopicOf Enalaprilat.