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- FIE3_(ftz_instability_element_3')_element abstract "The FIE3 (ftz instability element 3') element is an RNA element found in the 3' UTR of the fushi tarazu mRNA.The fushi tarazu gene is essential for the establishment of the Drosophila embryonic body plan. When first expressed in early embryogenesis, fushi tarazu mRNA is uniformly distributed over most of the embryo. Subsequently, fushi tarazu mRNA expression rapidly evolves into a pattern of seven stripes that encircle the embryo. The instability of fushi tarazu mRNA may contribute to the localization of this pattern of expression, but this is unlikely to be a dominant effect since the 744 base-pair ftz zebra stripe element can drive the ectopic expression of a reporter construct (with mRNA structure entirely unrelated to the ftz transcript) in a qualitatively highly similar pattern. Experiments provide evidence for at least two destabilising elements in the fushi tarazu mRNA, one located within the 5' one-third of the mRNA and the other near the 3' end (termed FIE3 for ftz instability element 3'). The FIE3 lies within a 201-nucleotide sequence just upstream of the polyadenylation signal and can act autonomously to destabilise a heterologous mRNA. Further deletion constructs identified an essential 68-nucleotide element within the FIE3. Although this element is predicted to contain a secondary structure, it also contains a GU rich sequence (UGUUUUGUUU) that is similar to GU rich instability elements subsequently identified in other systems.".
- FIE3_(ftz_instability_element_3')_element thumbnail RF00227.jpg?width=300.
- FIE3_(ftz_instability_element_3')_element wikiPageID "11420827".
- FIE3_(ftz_instability_element_3')_element wikiPageRevisionID "603895110".
- FIE3_(ftz_instability_element_3')_element caption "Predicted secondary structure and sequence conservation of FIE3".
- FIE3_(ftz_instability_element_3')_element hasPhotoCollection FIE3_(ftz_instability_element_3')_element.
- FIE3_(ftz_instability_element_3')_element id "RF00227".
- FIE3_(ftz_instability_element_3')_element name "FIE3 element".
- FIE3_(ftz_instability_element_3')_element rfam "RF00227".
- FIE3_(ftz_instability_element_3')_element rnaType Cis-regulatory_element.
- FIE3_(ftz_instability_element_3')_element symbol "FIE3".
- FIE3_(ftz_instability_element_3')_element taxDomain Eukaryote.
- FIE3_(ftz_instability_element_3')_element subject Category:RNA.
- FIE3_(ftz_instability_element_3')_element comment "The FIE3 (ftz instability element 3') element is an RNA element found in the 3' UTR of the fushi tarazu mRNA.The fushi tarazu gene is essential for the establishment of the Drosophila embryonic body plan. When first expressed in early embryogenesis, fushi tarazu mRNA is uniformly distributed over most of the embryo. Subsequently, fushi tarazu mRNA expression rapidly evolves into a pattern of seven stripes that encircle the embryo.".
- FIE3_(ftz_instability_element_3')_element label "FIE3 (ftz instability element 3') element".
- FIE3_(ftz_instability_element_3')_element sameAs m.02rbxrv.
- FIE3_(ftz_instability_element_3')_element sameAs Q5425709.
- FIE3_(ftz_instability_element_3')_element sameAs Q5425709.
- FIE3_(ftz_instability_element_3')_element wasDerivedFrom FIE3_(ftz_instability_element_3')_element?oldid=603895110.
- FIE3_(ftz_instability_element_3')_element depiction RF00227.jpg.
- FIE3_(ftz_instability_element_3')_element isPrimaryTopicOf FIE3_(ftz_instability_element_3')_element.
