Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Griffith's_experiment> ?p ?o. }
Showing items 1 to 53 of
53
with 100 items per page.
- Griffith's_experiment abstract "Griffith's experiment, reported in 1928 by Frederick Griffith, was one of the first experiments suggesting that bacteria are capable of transferring genetic information through a process known as transformation. Griffith's findings were followed by research in the late 1930s and early 40s that isolated DNA as the material that communicated this genetic information.Pneumonia was a serious cause of death in the wake of the post-WWI Spanish influenza pandemic, and Griffith was studying the possibility of creating a vaccine. Griffith used two strains of pneumococcus (Streptococcus pneumoniae) bacteria which infect mice – a type III-S (smooth) and type II-R (rough) strain. The III-S strain covers itself with a polysaccharide capsule that protects it from the host's immune system, resulting in the death of the host, while the II-R strain doesn't have that protective capsule and is defeated by the host's immune system. A German bacteriologist, Fred Neufeld, had discovered the three pneumococcal types (Types I, II, and III) and discovered the Quellung reaction to identify them in vitro. Until Griffith's experiment, bacteriologists believed that the types were fixed and unchangeable, from one generation to another.In this experiment, bacteria from the III-S strain were killed by heat, and their remains were added to II-R strain bacteria. While neither alone harmed the mice, the combination was able to kill its host. Griffith was also able to isolate both live II-R and live III-S strains of pneumococcus from the blood of these dead mice. Griffith concluded that the type II-R had been "transformed" into the lethal III-S strain by a "transforming principle" that was somehow part of the dead III-S strain bacteria.Today, we know that the "transforming principle" Griffith observed was the DNA of the III-S strain bacteria. While the bacteria had been killed, the DNA had survived the heating process and was taken up by the II-R strain bacteria. The III-S strain DNA contains the genes that form the protective polysaccharide capsule. Equipped with this gene, the former II-R strain bacteria were now protected from the host's immune system and could kill the host. The exact nature of the transforming principle (DNA) was verified in the experiments done by Avery, McLeod and McCarty and by Hershey and Chase.".
- Griffith's_experiment thumbnail Griffith_experiment.svg?width=300.
- Griffith's_experiment wikiPageExternalLink ?id=iwDn7ubDO2kC.
- Griffith's_experiment wikiPageExternalLink avery.html.
- Griffith's_experiment wikiPageExternalLink query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=33226.
- Griffith's_experiment wikiPageID "12718".
- Griffith's_experiment wikiPageRevisionID "604347866".
- Griffith's_experiment hasPhotoCollection Griffith's_experiment.
- Griffith's_experiment subject Category:1928_in_science.
- Griffith's_experiment subject Category:Genetics_experiments.
- Griffith's_experiment subject Category:Microbiology.
- Griffith's_experiment type Abstraction100002137.
- Griffith's_experiment type Act100030358.
- Griffith's_experiment type Activity100407535.
- Griffith's_experiment type Event100029378.
- Griffith's_experiment type Experiment100639556.
- Griffith's_experiment type GeneticsExperiments.
- Griffith's_experiment type Investigation100633864.
- Griffith's_experiment type PsychologicalFeature100023100.
- Griffith's_experiment type Research100636921.
- Griffith's_experiment type ScientificResearch100641820.
- Griffith's_experiment type Work100575741.
- Griffith's_experiment type YagoPermanentlyLocatedEntity.
- Griffith's_experiment comment "Griffith's experiment, reported in 1928 by Frederick Griffith, was one of the first experiments suggesting that bacteria are capable of transferring genetic information through a process known as transformation.".
- Griffith's_experiment label "Eksperyment Griffitha".
- Griffith's_experiment label "Esperimento di Griffith".
- Griffith's_experiment label "Experiment van Griffith".
- Griffith's_experiment label "Experimento de Griffith".
- Griffith's_experiment label "Expérience de Griffith".
- Griffith's_experiment label "Griffith's experiment".
- Griffith's_experiment label "Griffiths Experiment".
- Griffith's_experiment label "Эксперимент Гриффита".
- Griffith's_experiment label "تجربة غريفيث".
- Griffith's_experiment label "グリフィスの実験".
- Griffith's_experiment label "格里菲斯實驗".
- Griffith's_experiment sameAs Griffiths_Experiment.
- Griffith's_experiment sameAs Πείραμα_του_Γκρίφιθ.
- Griffith's_experiment sameAs Experimento_de_Griffith.
- Griffith's_experiment sameAs Griffithen_esperimentua.
- Griffith's_experiment sameAs Expérience_de_Griffith.
- Griffith's_experiment sameAs Percobaan_Griffith.
- Griffith's_experiment sameAs Esperimento_di_Griffith.
- Griffith's_experiment sameAs グリフィスの実験.
- Griffith's_experiment sameAs 그리피스_실험.
- Griffith's_experiment sameAs Experiment_van_Griffith.
- Griffith's_experiment sameAs Eksperyment_Griffitha.
- Griffith's_experiment sameAs m.03bkk.
- Griffith's_experiment sameAs Q151141.
- Griffith's_experiment sameAs Q151141.
- Griffith's_experiment sameAs Griffith's_experiment.
- Griffith's_experiment wasDerivedFrom Griffith's_experiment?oldid=604347866.
- Griffith's_experiment depiction Griffith_experiment.svg.
- Griffith's_experiment isPrimaryTopicOf Griffith's_experiment.
