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• Huntington's_disease abstract "Huntington's disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and leads to cognitive decline and psychiatric problems. It typically becomes noticeable in mid-adult life. HD is the most common genetic cause of abnormal involuntary writhing movements called chorea, which is why the disease used to be called Huntington's chorea.It is much more common in people of Western European descent than in those of Asian or African ancestry. The disease can affect both men and women. The disease is caused by an autosomal dominant mutation in either of an individual's two copies of a gene called Huntingtin, which means any child of an affected person typically has a 50% chance of inheriting the disease. Physical symptoms of Huntington's disease can begin at any age from infancy to old age, but usually begin between 35 and 44 years of age. Through genetic anticipation, the disease may develop earlier in life in each successive generation. About 6% of cases start before the age of 21 years with an akinetic-rigid syndrome; they progress faster and vary slightly. The variant is classified as juvenile, akinetic-rigid or Westphal variant HD.The Huntingtin gene provides the genetic information for a protein that is also called "huntingtin". Expansion of a CAG (cytosine-adenine-guanine) triplet repeat stretch within the Huntingtin gene results in a different (mutant) form of the protein, which gradually damages cells in the brain, through mechanisms that are not fully understood. The genetic basis of HD was discovered in 1993 by an international collaborative effort spearheaded by the Hereditary Disease Foundation.Genetic testing can be performed at any stage of development, even before the onset of symptoms. This fact raises several ethical debates: the age at which an individual is considered mature enough to choose testing; whether parents have the right to have their children tested; and managing confidentiality and disclosure of test results. Genetic counseling has developed to inform and aid individuals considering genetic testing and has become a model for other genetically dominant diseases.Symptoms of the disease can vary between individuals and even among affected members of the same family, but usually progress predictably. The earliest symptoms are often subtle problems with mood or cognition. A general lack of coordination and an unsteady gait often follows. As the disease advances, uncoordinated, jerky body movements become more apparent, along with a decline in mental abilities and behavioral and psychiatric problems. Physical abilities are gradually impeded until coordinated movement becomes very difficult. Mental abilities generally decline into dementia. Complications such as pneumonia, heart disease, and physical injury from falls reduce life expectancy to around twenty years after symptoms begin. There is no cure for HD, and full-time care is required in the later stages of the disease. Existing pharmaceutical and non-drug treatments can relieve many of its symptoms.Research and support organizations, first founded in the 1960s and increasing in number, work to increase public awareness, to provide support for individuals and their families, and to promote and facilitate research. Many new research discoveries have been made and understanding of the disease is improving. Current research directions include determining the exact mechanism of the disease, improving animal models to expedite research, clinical trials of pharmaceuticals to treat symptoms or slow the progression of the disease, and studying procedures such as stem cell therapy with the goal of repairing damage caused by the disease.".
• Huntington's_disease diseasesdb "6060".
• Huntington's_disease emedicineSubject "article".
• Huntington's_disease emedicineTopic "1150165".
• Huntington's_disease icd10 "G10, F02.2".
• Huntington's_disease icd9 "333.4, 294.1".
• Huntington's_disease medlineplus "000770".
• Huntington's_disease meshId "D006816".
• Huntington's_disease omim "143100".
• Huntington's_disease thumbnail Neuron_with_mHtt_inclusion.jpg?width=300.
• Huntington's_disease wikiPageExternalLink hdbuzz.net.
• Huntington's_disease wikiPageExternalLink hddrugworks.org.
• Huntington's_disease wikiPageExternalLink hopes.stanford.edu.
• Huntington's_disease wikiPageID "47878".
• Huntington's_disease wikiPageRevisionID "604436196".
• Huntington's_disease alt "Several neurons colored yellow and having a large central core with up to two dozen tendrils branching out of them, the core of the neuron in the foreground contains an orange blob about a quarter of its diameter".
• Huntington's_disease caption "A microscope image of medium spiny neurons with nuclear inclusions , which occur as part of the disease process, image width 360 µm".
• Huntington's_disease diseasesdb "6060".
• Huntington's_disease emedicinesubj "article".
• Huntington's_disease emedicinetopic "1150165".
• Huntington's_disease hasPhotoCollection Huntington's_disease.
• Huntington's_disease icd "333.4".
• Huntington's_disease icd "G10, F02.2".
• Huntington's_disease medlineplus "770".
• Huntington's_disease meshid "D006816".
• Huntington's_disease name "Huntington's disease".
• Huntington's_disease omim "143100".
• Huntington's_disease wordnet_type synset-disease-noun-1.
• Huntington's_disease subject Category:Autosomal_dominant_disorders.
• Huntington's_disease subject Category:Extrapyramidal_and_movement_disorders.
• Huntington's_disease subject Category:Genetic_disorders.
• Huntington's_disease subject Category:Huntington's_disease.
• Huntington's_disease subject Category:Systemic_atrophies_primarily_affecting_the_central_nervous_system.
• Huntington's_disease subject Category:Trinucleotide_repeat_disorders.
• Huntington's_disease type Abstraction100002137.
• Huntington's_disease type Attribute100024264.
• Huntington's_disease type Condition113920835.
• Huntington's_disease type Disease114070360.
• Huntington's_disease type GeneticDisease114151139.
• Huntington's_disease type GeneticDisorders.
• Huntington's_disease type IllHealth114052046.
• Huntington's_disease type Illness114061805.
• Huntington's_disease type PathologicalState114051917.
• Huntington's_disease type PhysicalCondition114034177.
• Huntington's_disease type State100024720.
• Huntington's_disease type Disease.
• Huntington's_disease type AilmentCondition.
• Huntington's_disease type Situation.
• Huntington's_disease comment "Huntington's disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and leads to cognitive decline and psychiatric problems. It typically becomes noticeable in mid-adult life. HD is the most common genetic cause of abnormal involuntary writhing movements called chorea, which is why the disease used to be called Huntington's chorea.It is much more common in people of Western European descent than in those of Asian or African ancestry.".
• Huntington's_disease label "Chorea Huntington".
• Huntington's_disease label "Doença de Huntington".
• Huntington's_disease label "Enfermedad de Huntington".
• Huntington's_disease label "Huntington's disease".
• Huntington's_disease label "Maladie de Huntington".
• Huntington's_disease label "Malattia di Huntington".
• Huntington's_disease label "Pląsawica Huntingtona".
• Huntington's_disease label "Ziekte van Huntington".
• Huntington's_disease label "Болезнь Хантингтона".
• Huntington's_disease label "داء هنتنغتون".
• Huntington's_disease label "ハンチントン病".
• Huntington's_disease label "亨丁頓舞蹈症".
• Huntington's_disease sameAs Huntingtonova_choroba.
• Huntington's_disease sameAs Chorea_Huntington.
• Huntington's_disease sameAs Νόσος_του_Χάντινγκτον.
• Huntington's_disease sameAs Enfermedad_de_Huntington.
• Huntington's_disease sameAs Huntingtonen_gaixotasuna.
• Huntington's_disease sameAs Maladie_de_Huntington.
• Huntington's_disease sameAs Penyakit_Huntington.
• Huntington's_disease sameAs Malattia_di_Huntington.
• Huntington's_disease sameAs ハンチントン病.
• Huntington's_disease sameAs 헌팅턴병.
• Huntington's_disease sameAs Ziekte_van_Huntington.
• Huntington's_disease sameAs Pląsawica_Huntingtona.
• Huntington's_disease sameAs Doença_de_Huntington.
• Huntington's_disease sameAs m.0cvql.
• Huntington's_disease sameAs Q190564.
• Huntington's_disease sameAs Q190564.
• Huntington's_disease sameAs 2641.
• Huntington's_disease sameAs 529.
• Huntington's_disease sameAs Huntington's_disease.
• Huntington's_disease wasDerivedFrom Huntington's_disease?oldid=604436196.
• Huntington's_disease depiction Neuron_with_mHtt_inclusion.jpg.
• Huntington's_disease isPrimaryTopicOf Huntington's_disease.
• Huntington's_disease name "Huntington's disease (HD)".