Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Levinthal's_paradox> ?p ?o. }
Showing items 1 to 50 of
50
with 100 items per page.
- Levinthal's_paradox abstract "Levinthal's paradox is a thought experiment, also constituting a self-reference in the theory of protein folding. In 1969, Cyrus Levinthal noted that, because of the very large number of degrees of freedom in an unfolded polypeptide chain, the molecule has an astronomical number of possible conformations. An estimate of 3300 or 10143 was made in one of his papers. (Often incorrectly cited as a 1968 paper.) For example, a polypeptide of 100 residues will have 99 peptide bonds, and therefore 198 different phi and psi bond angles. If each of these bond angles can be in one of three stable conformations, the protein may misfold into a maximum of 3198 different conformations (including any possible folding redundancy). Therefore if a protein were to attain its correctly folded configuration by sequentially sampling all the possible conformations, it would require a time longer than the age of the universe to arrive at its correct native conformation. This is true even if conformations are sampled at rapid (nanosecond or picosecond) rates. The "paradox" is that most small proteins fold spontaneously on a millisecond or even microsecond time scale. This paradox is central to computational approaches to protein structure prediction.Levinthal himself was aware that proteins fold spontaneously and on short timescales. He suggested that the paradox can be resolved if "protein folding is sped up and guided by the rapid formation of local interactions which then determine the further folding of the peptide; this suggests local amino acid sequences which form stable interactions and serve as nucleation points in the folding process." Indeed, the protein folding intermediates and the partially folded transition states were experimentally detected, which explains the fast protein folding. This is also described as protein folding directed within funnel-like energy landscapes Some computational approaches to protein structure prediction have sought to identify and simulate the mechanism of protein folding.Levinthal also suggested that the native structure might have a higher energy, if the lowest energy was not kinetically accessible. An analogy is a rock tumbling down a hillside that lodges in a gully rather than reaching the base.".
- Levinthal's_paradox wikiPageExternalLink levinthal.html.
- Levinthal's_paradox wikiPageExternalLink levinthal.html.
- Levinthal's_paradox wikiPageExternalLink blue_pr.html.
- Levinthal's_paradox wikiPageID "579400".
- Levinthal's_paradox wikiPageRevisionID "601320704".
- Levinthal's_paradox hasPhotoCollection Levinthal's_paradox.
- Levinthal's_paradox subject Category:Physical_paradoxes.
- Levinthal's_paradox subject Category:Protein_structure.
- Levinthal's_paradox subject Category:Thought_experiments.
- Levinthal's_paradox type Abstraction100002137.
- Levinthal's_paradox type Act100030358.
- Levinthal's_paradox type Activity100407535.
- Levinthal's_paradox type Communication100033020.
- Levinthal's_paradox type Contradiction107206887.
- Levinthal's_paradox type Event100029378.
- Levinthal's_paradox type Experiment100639556.
- Levinthal's_paradox type Falsehood106756407.
- Levinthal's_paradox type Investigation100633864.
- Levinthal's_paradox type Message106598915.
- Levinthal's_paradox type Paradox106724559.
- Levinthal's_paradox type PhysicalParadoxes.
- Levinthal's_paradox type PsychologicalFeature100023100.
- Levinthal's_paradox type Research100636921.
- Levinthal's_paradox type ScientificResearch100641820.
- Levinthal's_paradox type Statement106722453.
- Levinthal's_paradox type ThoughtExperiments.
- Levinthal's_paradox type Work100575741.
- Levinthal's_paradox type YagoPermanentlyLocatedEntity.
- Levinthal's_paradox comment "Levinthal's paradox is a thought experiment, also constituting a self-reference in the theory of protein folding. In 1969, Cyrus Levinthal noted that, because of the very large number of degrees of freedom in an unfolded polypeptide chain, the molecule has an astronomical number of possible conformations. An estimate of 3300 or 10143 was made in one of his papers.".
- Levinthal's_paradox label "Levinthal's paradox".
- Levinthal's_paradox label "Levinthal-Paradox".
- Levinthal's_paradox label "Levinthalparadox".
- Levinthal's_paradox label "Paradoja de Levinthal".
- Levinthal's_paradox label "Paradosso di Levinthal".
- Levinthal's_paradox label "Paradoxe de Levinthal".
- Levinthal's_paradox label "Парадокс Левинталя".
- Levinthal's_paradox label "利文索尔佯谬".
- Levinthal's_paradox sameAs Levinthal-Paradox.
- Levinthal's_paradox sameAs Paradoja_de_Levinthal.
- Levinthal's_paradox sameAs Paradoxe_de_Levinthal.
- Levinthal's_paradox sameAs Paradosso_di_Levinthal.
- Levinthal's_paradox sameAs 레빈탈의_역설.
- Levinthal's_paradox sameAs Levinthalparadox.
- Levinthal's_paradox sameAs m.02s0hy.
- Levinthal's_paradox sameAs Q899017.
- Levinthal's_paradox sameAs Q899017.
- Levinthal's_paradox sameAs Levinthal's_paradox.
- Levinthal's_paradox wasDerivedFrom Levinthal's_paradox?oldid=601320704.
- Levinthal's_paradox isPrimaryTopicOf Levinthal's_paradox.