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- Lithium_orotate abstract "Lithium orotate, is a salt of orotic acid and lithium. It is available as the monohydrate, LiC5H3N2O4·H2O. In this compound, lithium is non-covalently bound to an orotate ion, rather than to a carbonate or other ion. It is marketed as a dietary supplement used in small doses to treat certain medical conditions, such as stress, bipolar disorder, depression, suicidal ideations, alcoholism, ADHD, attention deficit disorder, aggression, PTSD, Alzheimer's and to improve memory. Intake of lithium has well documented positive neurological effects, and appears to be effective even in trace amounts. Still, lithium orotate's safety remains in question. There have been numerous case reports of patients requiring medical attention after taking lithium orotate supplements.While lithium orotate is capable of providing lithium to the body, like lithium carbonate and other lithium salts, there are no systematic reviews supporting the efficacy of lithium orotate and it is not approved by the U.S. Food and Drug Administration (FDA) for the treatment of any medical condition. A 1979 study found that its use may in fact be harmful to kidney function compared to lithium carbonate.In 1973, Nieper reported that lithium orotate contained 3.83 mg of elemental lithium per 100 mg and lithium carbonate contained 18.8 mg of elemental lithium per 100 mg. Nieper went on to claim that lithium did not dissolve from the orotate carrier until it passed through the blood brain barrier, however a 1976 study documented that lithium concentrations within the brains of rats were not statistically different between equivalent dosages of lithium from lithium orotate, lithium carbonate, or lithium chloride. While this study was conducted with rats, it directly contradicts the aforementioned assumptions made by Nieper and others. The pharmacokinetics of lithium orotate in human brains is poorly documented and further inquiry is needed to affirm that lithium concentrations in the brain are higher with lithium orotate. Major medical research has not been conducted on lithium orotate since the 1980s due to its patent status and the abundant availability of lithium carbonate. As previously stated, lithium intake appears to be effective even at low doses, and this may account for lithium orotates claimed effectiveness.".
- Lithium_orotate casNumber "5266-20-6".
- Lithium_orotate pubchem "23686432".
- Lithium_orotate thumbnail Lithium-orotate-2D-skeletal.png?width=300.
- Lithium_orotate wikiPageExternalLink Lithium-Orotate.htm.
- Lithium_orotate wikiPageExternalLink lithium-orotate.
- Lithium_orotate wikiPageExternalLink lithium-orotate.html.
- Lithium_orotate wikiPageExternalLink exp1121602b.html.
- Lithium_orotate wikiPageID "693170".
- Lithium_orotate wikiPageRevisionID "605907865".
- Lithium_orotate c "5".
- Lithium_orotate casNumber "5266".
- Lithium_orotate h "3".
- Lithium_orotate hasPhotoCollection Lithium_orotate.
- Lithium_orotate image "Lithium-orotate-from-xtal-3D-vdW.png".
- Lithium_orotate legalStatus "OTC".
- Lithium_orotate li "1".
- Lithium_orotate molecularWeight "162.03".
- Lithium_orotate n "2".
- Lithium_orotate o "4".
- Lithium_orotate pregnancyUs "X".
- Lithium_orotate pubchem "23686432".
- Lithium_orotate routesOfAdministration "Oral".
- Lithium_orotate verifiedrevid "450705490".
- Lithium_orotate watchedfields "changed".
- Lithium_orotate width "150".
- Lithium_orotate subject Category:Lithium_compounds.
- Lithium_orotate type Abstraction100002137.
- Lithium_orotate type Cognition100023271.
- Lithium_orotate type Compound105870180.
- Lithium_orotate type Concept105835747.
- Lithium_orotate type Content105809192.
- Lithium_orotate type Idea105833840.
- Lithium_orotate type LithiumCompounds.
- Lithium_orotate type PsychologicalFeature100023100.
- Lithium_orotate type Whole105869584.
- Lithium_orotate type Drug.
- Lithium_orotate type DrugProduct.
- Lithium_orotate type FunctionalSubstance.
- Lithium_orotate comment "Lithium orotate, is a salt of orotic acid and lithium. It is available as the monohydrate, LiC5H3N2O4·H2O. In this compound, lithium is non-covalently bound to an orotate ion, rather than to a carbonate or other ion. It is marketed as a dietary supplement used in small doses to treat certain medical conditions, such as stress, bipolar disorder, depression, suicidal ideations, alcoholism, ADHD, attention deficit disorder, aggression, PTSD, Alzheimer's and to improve memory.".
- Lithium_orotate label "Lithium orotate".
- Lithium_orotate label "Orotato de lítio".
- Lithium_orotate sameAs Orotato_de_lítio.
- Lithium_orotate sameAs m.0339f9.
- Lithium_orotate sameAs Q6647963.
- Lithium_orotate sameAs Q6647963.
- Lithium_orotate sameAs Lithium_orotate.
- Lithium_orotate wasDerivedFrom Lithium_orotate?oldid=605907865.
- Lithium_orotate depiction Lithium-orotate-2D-skeletal.png.
- Lithium_orotate isPrimaryTopicOf Lithium_orotate.
