Matches in DBpedia 2014 for { <http://dbpedia.org/resource/N-(2-Hydroxypropyl)_methacrylamide> ?p ?o. }
Showing items 1 to 25 of
25
with 100 items per page.
- N-(2-Hydroxypropyl)_methacrylamide abstract "N-(2-Hydroxypropyl)methacrylamide or HPMA is the monomer used to make the polymer poly(N-(2-hydroxypropyl)methacrylamide). The polymer is water-soluble (highly hydrophilic), non-immunogenic and non-toxic, and resides in the blood circulation well. Thus, it is frequently used as macromolecular carriers for low molecular weight drugs (especially anti-cancer chemotherapeutic agents) to enhance therapeutic efficacy and limit side effects. Poly(HPMA)-drug conjugate preferably accumulates in tumor tissues via the passive-targeting process (or so-called EPR effect). Due to its favorable characteristics, HPMA polymers and copolymers are also commonly used to produce synthetic biocompatible medical materials such as hydrogels.The development of pHPMA as anti-cancer drug delivery vehicles is initiated by Dr. Jindřich Kopeček and colleagues at the Czech (-oslovak) Academy of Sciences in Prague in the mid-1970s. Prior to this, it was used as a plasma expander. The Kopeček Laboratory designed and developed HPMA copolymer-drug conjugates as a lysosomal delivery vehicle to cancer cells. The concept of using pHPMA as polymeric drug carriers has opened a new perspective in modern pharmaceutical science, and developed into the first polymer-drug conjugate entering clinical trials (i.e. PK1; HPMA copolymer-doxorubicin conjugate).".
- N-(2-Hydroxypropyl)_methacrylamide iupacName "N-(2-Hydroxypropyl)methacrylamide".
- N-(2-Hydroxypropyl)_methacrylamide thumbnail HPMA.png?width=300.
- N-(2-Hydroxypropyl)_methacrylamide wikiPageID "36292499".
- N-(2-Hydroxypropyl)_methacrylamide wikiPageRevisionID "599210550".
- N-(2-Hydroxypropyl)_methacrylamide hasPhotoCollection N-(2-Hydroxypropyl)_methacrylamide.
- N-(2-Hydroxypropyl)_methacrylamide imagefile "HPMA.png".
- N-(2-Hydroxypropyl)_methacrylamide imagesize "200".
- N-(2-Hydroxypropyl)_methacrylamide iupacname "N-methacrylamide".
- N-(2-Hydroxypropyl)_methacrylamide name "N- methacrylamide".
- N-(2-Hydroxypropyl)_methacrylamide subject Category:Amides.
- N-(2-Hydroxypropyl)_methacrylamide subject Category:Monomers.
- N-(2-Hydroxypropyl)_methacrylamide type ChemicalCompound.
- N-(2-Hydroxypropyl)_methacrylamide type ChemicalSubstance.
- N-(2-Hydroxypropyl)_methacrylamide type ChemicalObject.
- N-(2-Hydroxypropyl)_methacrylamide type Thing.
- N-(2-Hydroxypropyl)_methacrylamide comment "N-(2-Hydroxypropyl)methacrylamide or HPMA is the monomer used to make the polymer poly(N-(2-hydroxypropyl)methacrylamide). The polymer is water-soluble (highly hydrophilic), non-immunogenic and non-toxic, and resides in the blood circulation well. Thus, it is frequently used as macromolecular carriers for low molecular weight drugs (especially anti-cancer chemotherapeutic agents) to enhance therapeutic efficacy and limit side effects.".
- N-(2-Hydroxypropyl)_methacrylamide label "N-(2-Hydroxypropyl) methacrylamide".
- N-(2-Hydroxypropyl)_methacrylamide sameAs m.0k3ljz_.
- N-(2-Hydroxypropyl)_methacrylamide sameAs Q6951330.
- N-(2-Hydroxypropyl)_methacrylamide sameAs Q6951330.
- N-(2-Hydroxypropyl)_methacrylamide wasDerivedFrom N-(2-Hydroxypropyl)_methacrylamide?oldid=599210550.
- N-(2-Hydroxypropyl)_methacrylamide depiction HPMA.png.
- N-(2-Hydroxypropyl)_methacrylamide isPrimaryTopicOf N-(2-Hydroxypropyl)_methacrylamide.
- N-(2-Hydroxypropyl)_methacrylamide name "N-(2-Hydroxypropyl) methacrylamide".
