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• Paget's_disease_of_bone abstract "Paget's disease of bone or Paget disease of bone (/ˈpædʒɨt/, rhymes with "gadget") is a chronic disorder that can result in enlarged and misshapen bones. Paget's is caused by the excessive breakdown and formation of bone, followed by disorganized bone remodelling. This causes affected bone to weaken, resulting in pain, misshapen bones, fractures, and arthritis in the joints near the affected bones. Often Paget's disease is localized to only a few bones in the body. The pelvis, femur, and lower lumbar vertebrae are the most commonly affected bones. The disease is named after Sir James Paget.Paget's disease typically is localized, affecting just one or a few bones, as opposed to osteoporosis, for example, which usually affects all the bones in the body.Decisions about treating Paget's disease may be complicated because people are often affected very differently by Paget's disease, and it is sometimes difficult to predict whether a person with Paget's disease who shows no signs or symptoms of the disorder will develop symptoms or complications (such as a bone fracture) in the future.Although there is no cure for Paget's disease, medications (bisphosphonates and calcitonin) can help control the disorder and lessen pain and other symptoms. These medications are usually recommended for people with Paget's disease whohave bone pain, headache, back pain, or a nerve-related symptom (such as "shooting" pains in the leg) that is directly associated with the disease;have elevated levels of serum alkaline phosphatase (ALP) in their blood;display evidence that a bone fracture will occur;require pretreatment therapy for affected bones that require surgery;have active symptoms in the skull, long bones, or vertebrae (spine);have the disease in bones located next to major joints, placing them at risk of developing osteoarthritis;develop hypercalcemia that occurs when a person with several bones affected by Paget's disease and a high serum alkaline phosphatase level is immobilized.Medications are often successful in controlling the disorder, especially when started before complications begin.Paget's disease is rare in people less than 55 years of age. Men are more commonly affected than women (3:2). The prevalence of Paget's disease ranges from 1.5 to 8.0 percent, depending on age and country of residence. Because early diagnosis and treatment is important, after age 40, siblings and children of someone with Paget's disease may wish to have an alkaline phosphatase blood test every two or three years. If the alkaline phosphatase level is above normal, other tests such as a bone-specific alkaline phosphatase test, bone scan, or X-ray can be performed.".
• Paget's_disease_of_bone diseasesdb "9479".
• Paget's_disease_of_bone emedicineSubject "med".
• Paget's_disease_of_bone emedicineTopic "2998".
• Paget's_disease_of_bone icd10 "M88".
• Paget's_disease_of_bone icd9 "731.0".
• Paget's_disease_of_bone medlineplus "000414".
• Paget's_disease_of_bone meshId "D010001".
• Paget's_disease_of_bone omim "602080".
• Paget's_disease_of_bone thumbnail Pagets_skull.jpg?width=300.
• Paget's_disease_of_bone wikiPageExternalLink www.paget.org.uk.
• Paget's_disease_of_bone wikiPageExternalLink www.paget.org.
• Paget's_disease_of_bone wikiPageID "650007".
• Paget's_disease_of_bone wikiPageRevisionID "601569418".
• Paget's_disease_of_bone caption ""This 92 year-old male patient presented for assessment of acute hemiparesis. An incidental finding was marked thickening of the calvarium. The diploic space is widened and there are ill-defined sclerotic and lucent areas throughout. The cortex is thickened and irregular. The findings probably correspond to the “cotton wool spots” seen on plain films in the later stages of Paget’s disease."".
• Paget's_disease_of_bone diseasesdb "9479".
• Paget's_disease_of_bone emedicinesubj "med".
• Paget's_disease_of_bone emedicinetopic "2998".
• Paget's_disease_of_bone hasPhotoCollection Paget's_disease_of_bone.
• Paget's_disease_of_bone icd "731".
• Paget's_disease_of_bone icd "M88".
• Paget's_disease_of_bone medlineplus "414".
• Paget's_disease_of_bone meshid "D010001".
• Paget's_disease_of_bone name "Paget's disease of bone".
• Paget's_disease_of_bone omim "602080".
• Paget's_disease_of_bone wordnet_type synset-disease-noun-1.
• Paget's_disease_of_bone subject Category:Osteitis.
• Paget's_disease_of_bone subject Category:Osteopathies.
• Paget's_disease_of_bone type Abstraction100002137.
• Paget's_disease_of_bone type Act100030358.
• Paget's_disease_of_bone type Activity100407535.
• Paget's_disease_of_bone type Attribute100024264.
• Paget's_disease_of_bone type Care100654885.
• Paget's_disease_of_bone type Condition113920835.
• Paget's_disease_of_bone type Disease114070360.
• Paget's_disease_of_bone type Event100029378.
• Paget's_disease_of_bone type IllHealth114052046.
• Paget's_disease_of_bone type Illness114061805.
• Paget's_disease_of_bone type Osteopathies.
• Paget's_disease_of_bone type Osteopathy100709205.
• Paget's_disease_of_bone type PathologicalState114051917.
• Paget's_disease_of_bone type PhysicalCondition114034177.
• Paget's_disease_of_bone type PsychologicalFeature100023100.
• Paget's_disease_of_bone type State100024720.
• Paget's_disease_of_bone type Treatment100658082.
• Paget's_disease_of_bone type Work100575741.
• Paget's_disease_of_bone type YagoPermanentlyLocatedEntity.
• Paget's_disease_of_bone type Disease.
• Paget's_disease_of_bone type AilmentCondition.
• Paget's_disease_of_bone type Situation.
• Paget's_disease_of_bone comment "Paget's disease of bone or Paget disease of bone (/ˈpædʒɨt/, rhymes with "gadget") is a chronic disorder that can result in enlarged and misshapen bones. Paget's is caused by the excessive breakdown and formation of bone, followed by disorganized bone remodelling. This causes affected bone to weaken, resulting in pain, misshapen bones, fractures, and arthritis in the joints near the affected bones. Often Paget's disease is localized to only a few bones in the body.".
• Paget's_disease_of_bone label "Choroba Pageta kości".
• Paget's_disease_of_bone label "Doença de Paget do osso".
• Paget's_disease_of_bone label "Maladie osseuse de Paget".
• Paget's_disease_of_bone label "Malattia ossea di Paget".
• Paget's_disease_of_bone label "Osteodystrophia deformans".
• Paget's_disease_of_bone label "Osteítis deformante".
• Paget's_disease_of_bone label "Paget's disease of bone".
• Paget's_disease_of_bone label "Ziekte van Paget".
• Paget's_disease_of_bone label "مرض باجيت".
• Paget's_disease_of_bone sameAs Osteodystrophia_deformans.
• Paget's_disease_of_bone sameAs Osteítis_deformante.
• Paget's_disease_of_bone sameAs Maladie_osseuse_de_Paget.
• Paget's_disease_of_bone sameAs Penyakit_Tulang_Paget.
• Paget's_disease_of_bone sameAs Malattia_ossea_di_Paget.
• Paget's_disease_of_bone sameAs Ziekte_van_Paget.
• Paget's_disease_of_bone sameAs Choroba_Pageta_kości.
• Paget's_disease_of_bone sameAs Doença_de_Paget_do_osso.
• Paget's_disease_of_bone sameAs m.02_jyw.
• Paget's_disease_of_bone sameAs Q2035074.
• Paget's_disease_of_bone sameAs Q2035074.
• Paget's_disease_of_bone sameAs C0029401.
• Paget's_disease_of_bone sameAs Paget's_disease_of_bone.
• Paget's_disease_of_bone wasDerivedFrom Paget's_disease_of_bone?oldid=601569418.
• Paget's_disease_of_bone depiction Pagets_skull.jpg.
• Paget's_disease_of_bone isPrimaryTopicOf Paget's_disease_of_bone.
• Paget's_disease_of_bone name "Paget's disease of bone".