Matches in DBpedia 2014 for { ?s ?p 2-Methoxyestradiol (2ME2) is a natural metabolite of estradiol. As an experimental drug candidate, it is being developed under the tradename of Panzem. It prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis), hence it is an angiogenesis inhibitor.It also acts as a vasodilator.[citation needed]2ME2 is derived from estrogen, although it binds poorly to known estrogen receptors.It induces apoptosis in some cancer cell lines.It has undergone Phase 1 clinical trials against breast cancer.[citation needed]A phase II trial of 18 advanced ovarian cancer patients reported encouraging results in Oct 2007.Preclinical models also suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. Several studies have been conducted showing 2ME2 is a microtubule-inhibitor and effective against prostate cancer in rodents.[citation needed]The CAS name for 2ME2 is (17 beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diol.. }
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- 2-Methoxyestradiol abstract "2-Methoxyestradiol (2ME2) is a natural metabolite of estradiol. As an experimental drug candidate, it is being developed under the tradename of Panzem. It prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis), hence it is an angiogenesis inhibitor.It also acts as a vasodilator.[citation needed]2ME2 is derived from estrogen, although it binds poorly to known estrogen receptors.It induces apoptosis in some cancer cell lines.It has undergone Phase 1 clinical trials against breast cancer.[citation needed]A phase II trial of 18 advanced ovarian cancer patients reported encouraging results in Oct 2007.Preclinical models also suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. Several studies have been conducted showing 2ME2 is a microtubule-inhibitor and effective against prostate cancer in rodents.[citation needed]The CAS name for 2ME2 is (17 beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diol.".