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- 2-Methoxyestradiol abstract "2-Methoxyestradiol (2ME2) is a natural metabolite of estradiol. As an experimental drug candidate, it is being developed under the tradename of Panzem. It prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis), hence it is an angiogenesis inhibitor.It also acts as a vasodilator.[citation needed]2ME2 is derived from estrogen, although it binds poorly to known estrogen receptors.It induces apoptosis in some cancer cell lines.It has undergone Phase 1 clinical trials against breast cancer.[citation needed]A phase II trial of 18 advanced ovarian cancer patients reported encouraging results in Oct 2007.Preclinical models also suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. Several studies have been conducted showing 2ME2 is a microtubule-inhibitor and effective against prostate cancer in rodents.[citation needed]The CAS name for 2ME2 is (17 beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diol.".
- 2-Methoxyestradiol casNumber "362-07-2".
- 2-Methoxyestradiol chEBI "28955".
- 2-Methoxyestradiol fdaUniiCode "6I2QW73SR5".
- 2-Methoxyestradiol iupacName "(8R,9S,13S,14S,17S)-2-methoxy-".
- 2-Methoxyestradiol iupacName "13-methyl-6,7,8,9,11,12,14,15,16,17-".
- 2-Methoxyestradiol iupacName "decahydrocyclopenta[a]phenanthrene-3,17-diol".
- 2-Methoxyestradiol pubchem "66414".
- 2-Methoxyestradiol thumbnail 2-Methoxyestradiol.svg?width=300.
- 2-Methoxyestradiol wikiPageExternalLink detail.go?type=chem&acc=C022830.
- 2-Methoxyestradiol wikiPageExternalLink dispprod.php?ItemId=78389.
- 2-Methoxyestradiol wikiPageID "1300633".
- 2-Methoxyestradiol wikiPageRevisionID "593768653".
- 2-Methoxyestradiol c "19".
- 2-Methoxyestradiol casNumber "0362-07-02".
- 2-Methoxyestradiol chebi "28955".
- 2-Methoxyestradiol chembl "299613".
- 2-Methoxyestradiol chemspiderid "59788".
- 2-Methoxyestradiol h "26".
- 2-Methoxyestradiol hasPhotoCollection 2-Methoxyestradiol.
- 2-Methoxyestradiol inchi "1".
- 2-Methoxyestradiol inchikey "CQOQDQWUFQDJMK-SSTWWWIQBL".
- 2-Methoxyestradiol iupacName "-2".
- 2-Methoxyestradiol iupacName "13".
- 2-Methoxyestradiol iupacName "decahydrocyclopenta[a]phenanthrene-3,17-diol".
- 2-Methoxyestradiol molecularWeight "302.408".
- 2-Methoxyestradiol o "3".
- 2-Methoxyestradiol pubchem "66414".
- 2-Methoxyestradiol smiles "Oc1cc3c[C@H]2CC[C@@]4C".
- 2-Methoxyestradiol stdinchi "1".
- 2-Methoxyestradiol stdinchikey "CQOQDQWUFQDJMK-SSTWWWIQSA-N".
- 2-Methoxyestradiol unii "6".
- 2-Methoxyestradiol verifiedfields "changed".
- 2-Methoxyestradiol verifiedrevid "477213877".
- 2-Methoxyestradiol subject Category:Steroids.
- 2-Methoxyestradiol type Drug.
- 2-Methoxyestradiol type DrugProduct.
- 2-Methoxyestradiol type FunctionalSubstance.
- 2-Methoxyestradiol comment "2-Methoxyestradiol (2ME2) is a natural metabolite of estradiol. As an experimental drug candidate, it is being developed under the tradename of Panzem.".
- 2-Methoxyestradiol label "2-Methoxyestradiol".
- 2-Methoxyestradiol sameAs m.04r33q.
- 2-Methoxyestradiol sameAs Q4596897.
- 2-Methoxyestradiol sameAs Q4596897.
- 2-Methoxyestradiol wasDerivedFrom 2-Methoxyestradiol?oldid=593768653.
- 2-Methoxyestradiol depiction 2-Methoxyestradiol.svg.
- 2-Methoxyestradiol isPrimaryTopicOf 2-Methoxyestradiol.