Matches in DBpedia 2014 for { ?s ?p Ezetimibe /ɛˈzɛtɨmɪb/ is a drug that lowers plasma cholesterol levels. It acts by decreasing cholesterol absorption in the small intestine. It may be used alone (marketed as Zetia or Ezetrol), when other cholesterol-lowering medications are not tolerated, or together with statins (e.g., ezetimibe/simvastatin, marketed as Vytorin and Inegy) when statins alone do not control cholesterol. However, none of the studies have shown that ezetimibe reduced heart attack, stroke or death. Panels and experts have said that ezetimibe should only be used as a last resort for patients who can't tolerate other drugs, and possibly not even then. They have complained that ezetimibe is overpromoted and overprescribed. In the ARBITER 6-HALTS trial, subjects taking a statin plus ezetimibe had an increase in carotid intima–media thickness (CIMT), which is a measurement of the thickness of the arteries and correlated with atherosclerotic disease. They also had more adverse cardiovascular events than subjects taking a statin plus niacin. Subjects in the statin/niacin group had a decrease in CIMT thickness. Britain's NICE statement, published in 2007, endorses its use for monotherapy if statins are not tolerated or as add-on therapy.. }
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- Ezetimibe abstract "Ezetimibe /ɛˈzɛtɨmɪb/ is a drug that lowers plasma cholesterol levels. It acts by decreasing cholesterol absorption in the small intestine. It may be used alone (marketed as Zetia or Ezetrol), when other cholesterol-lowering medications are not tolerated, or together with statins (e.g., ezetimibe/simvastatin, marketed as Vytorin and Inegy) when statins alone do not control cholesterol. However, none of the studies have shown that ezetimibe reduced heart attack, stroke or death. Panels and experts have said that ezetimibe should only be used as a last resort for patients who can't tolerate other drugs, and possibly not even then. They have complained that ezetimibe is overpromoted and overprescribed. In the ARBITER 6-HALTS trial, subjects taking a statin plus ezetimibe had an increase in carotid intima–media thickness (CIMT), which is a measurement of the thickness of the arteries and correlated with atherosclerotic disease. They also had more adverse cardiovascular events than subjects taking a statin plus niacin. Subjects in the statin/niacin group had a decrease in CIMT thickness. Britain's NICE statement, published in 2007, endorses its use for monotherapy if statins are not tolerated or as add-on therapy.".