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- 2-_and_4-Quinolones abstract "The 2- and 4-quinolones are a class of bicyclic molecules, organic chemical structures that are related to the heteroaromatic coal tar isolate quinoline, see image at right. Specific quinoline molecules substituted with an hydroxyl functional group at carbons 2 and 4 (C-2 and C-4, see image) are most often observed in isomeric forms termed 2- and 4-quinolones, respectively (tautomers, relationships explained further below). The relative importance of 4-quinolones has increased with the discovery that such structures that also bear a carboxylic acid (-COOH) and other functional groups at particular sites on the ring have very potent bacteriocidal activities, inhibiting of a broad spectrum of Gram negative and Gram positive DNA gyrase and topoisomerase enzymes. Hence, they are very useful in antibacterial therapy. An example of such a 4-quinolone is "cipro" (ciprofloxacin, image at right), where the atoms of quinoline can be traced within this related structure. Ciprofloxacin is a "second-generation" fluoroquinolone antibacterial (see below), introduced by Bayer AG and still in wide use as the second decade of the new millennium begins.".
- 2-_and_4-Quinolones thumbnail Quinoline_numbered.svg?width=300.
- 2-_and_4-Quinolones wikiPageExternalLink ID160.htm.
- 2-_and_4-Quinolones wikiPageExternalLink ar_lab_quinlolones.html.
- 2-_and_4-Quinolones wikiPageExternalLink fluoroquinolonesHCP.htm.
- 2-_and_4-Quinolones wikiPageExternalLink struct-act-duatb05-bryskier.pdf.
- 2-_and_4-Quinolones wikiPageID "31690663".
- 2-_and_4-Quinolones wikiPageRevisionID "601728810".
- 2-_and_4-Quinolones hasPhotoCollection 2-_and_4-Quinolones.
- 2-_and_4-Quinolones subject Category:Quinolone_antibiotics.
- 2-_and_4-Quinolones comment "The 2- and 4-quinolones are a class of bicyclic molecules, organic chemical structures that are related to the heteroaromatic coal tar isolate quinoline, see image at right. Specific quinoline molecules substituted with an hydroxyl functional group at carbons 2 and 4 (C-2 and C-4, see image) are most often observed in isomeric forms termed 2- and 4-quinolones, respectively (tautomers, relationships explained further below).".
- 2-_and_4-Quinolones label "2- and 4-Quinolones".
- 2-_and_4-Quinolones sameAs m.0gmfhwv.
- 2-_and_4-Quinolones sameAs Q16240467.
- 2-_and_4-Quinolones sameAs Q16240467.
- 2-_and_4-Quinolones wasDerivedFrom 2-_and_4-Quinolones?oldid=601728810.
- 2-_and_4-Quinolones depiction Quinoline_numbered.svg.
- 2-_and_4-Quinolones isPrimaryTopicOf 2-_and_4-Quinolones.