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- 4-hydroxy-2-oxovalerate_aldolase abstract "In enzymology, a 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) is an enzyme that catalyzes the chemical reaction4-hydroxy-2-oxopentanoate acetaldehyde + pyruvateHence, this enzyme has one substrate, 4-hydroxy-2-oxopentanoate, and two products, acetaldehyde and pyruvate. Baker et al.. showed that BphI, a member of this family from Burkholderia xenovorans LB400 was able to utilize 4-hydroxy- 2-oxohexanoate (HOHA) with equal catalytic efficiency as 4-hydroxy-2-oxopentanoate, producing propionaldehyde + pyruvate. Furthermore, the enzyme was also able to catalyze the cleavage of 4-hydroxy-2-oxoheptanoate (HOHEP), forming butryaldehyde + pyruvate. Baker et al.. we also able to show that acetaldehyde and propionaldehyde are not released into the bulk solvent, but are channeled to an associated acetaldehyde dehydrogenase known as BphJ. This is the first demonstration of substrate channeling in this family of enzymes.This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming). Other names in common use include 4-hydroxy-2-ketovalerate aldolase, HOA, DmpG, BphI, 4-hydroxy-2-oxovalerate pyruvate-lyase, and 4-hydroxy-2-oxopentanoate pyruvate-lyase. This enzyme participates in 8 metabolic pathways: phenylalanine metabolism, benzoate degradation via hydroxylation, biphenyl degradation, toluene and xylene degradation, 1,4-dichlorobenzene degradation, fluorene degradation, carbazole degradation, and styrene degradation.".
- 4-hydroxy-2-oxovalerate_aldolase ecNumber "4.1.3.39".
- 4-hydroxy-2-oxovalerate_aldolase wikiPageID "14281586".
- 4-hydroxy-2-oxovalerate_aldolase wikiPageRevisionID "556511372".
- 4-hydroxy-2-oxovalerate_aldolase ecNumber "4.1".
- 4-hydroxy-2-oxovalerate_aldolase hasPhotoCollection 4-hydroxy-2-oxovalerate_aldolase.
- 4-hydroxy-2-oxovalerate_aldolase iubmbEcNumber "4".
- 4-hydroxy-2-oxovalerate_aldolase name "4".
- 4-hydroxy-2-oxovalerate_aldolase subject Category:EC_4.1.3.
- 4-hydroxy-2-oxovalerate_aldolase subject Category:Enzymes_of_unknown_structure.
- 4-hydroxy-2-oxovalerate_aldolase type Biomolecule.
- 4-hydroxy-2-oxovalerate_aldolase type Enzyme.
- 4-hydroxy-2-oxovalerate_aldolase type BiologicalObject.
- 4-hydroxy-2-oxovalerate_aldolase comment "In enzymology, a 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) is an enzyme that catalyzes the chemical reaction4-hydroxy-2-oxopentanoate acetaldehyde + pyruvateHence, this enzyme has one substrate, 4-hydroxy-2-oxopentanoate, and two products, acetaldehyde and pyruvate. Baker et al..".
- 4-hydroxy-2-oxovalerate_aldolase label "4-hydroxy-2-oxovalerate aldolase".
- 4-hydroxy-2-oxovalerate_aldolase sameAs m.03c_5fl.
- 4-hydroxy-2-oxovalerate_aldolase sameAs Q4637220.
- 4-hydroxy-2-oxovalerate_aldolase sameAs Q4637220.
- 4-hydroxy-2-oxovalerate_aldolase wasDerivedFrom 4-hydroxy-2-oxovalerate_aldolase?oldid=556511372.
- 4-hydroxy-2-oxovalerate_aldolase isPrimaryTopicOf 4-hydroxy-2-oxovalerate_aldolase.
- 4-hydroxy-2-oxovalerate_aldolase name "4-hydroxy-2-oxovalerate aldolase".