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- A-834,735 abstract "A-834,735 is a drug developed by Abbott Laboratories that acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors, with a Ki of 12nM at CB1 and 0.21nM at CB2. Replacing the aromatic 3-benzoyl or 3-naphthoyl group found in most indole derived cannabinoids, with the 3-tetramethylcyclopropylmethanone group of A-834,735 and related compounds, imparts significant selectivity for CB2, with most compounds from this group found to be highly selective CB2 agonists with little affinity for CB1. However low nanomolar CB1 binding affinity is retained with certain heterocyclic 1-position substituents such as (N-methylpiperidin-2-yl)methyl (cf. AM-1220, AM-1248), or the (tetrahydropyran-4-yl)methyl substituent of A-834,735, resulting in compounds that still show significant affinity and efficacy at both receptors despite being CB2 selective overall.".
- A-834,735 casNumber "895155-57-4".
- A-834,735 iupacName "1-(tetrahydropyran-4-ylmethyl)-1H-indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone".
- A-834,735 pubchem "11544639".
- A-834,735 thumbnail A-834735_structure.png?width=300.
- A-834,735 wikiPageID "30404865".
- A-834,735 wikiPageRevisionID "589910514".
- A-834,735 c "22".
- A-834,735 casNumber "895155".
- A-834,735 chembl "271158".
- A-834,735 chemspiderid "9719418".
- A-834,735 h "29".
- A-834,735 hasPhotoCollection A-834,735.
- A-834,735 iupacName "1".
- A-834,735 molecularWeight "339.47".
- A-834,735 n "1".
- A-834,735 o "2".
- A-834,735 pubchem "11544639".
- A-834,735 smiles "C4COCCC4Cnc2ccccc2c3CC1CC1C".
- A-834,735 stdinchi "1".
- A-834,735 stdinchikey "NQTMRZNYLIGQCF-UHFFFAOYSA-N".
- A-834,735 verifiedfields "changed".
- A-834,735 verifiedrevid "456505675".
- A-834,735 width "200".
- A-834,735 subject Category:Cannabinoids.
- A-834,735 subject Category:Cyclopropanes.
- A-834,735 subject Category:Pyrans.
- A-834,735 type Drug.
- A-834,735 type FunctionalSubstance.
- A-834,735 comment "A-834,735 is a drug developed by Abbott Laboratories that acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors, with a Ki of 12nM at CB1 and 0.21nM at CB2.".
- A-834,735 label "A-834,735".
- A-834,735 sameAs m.0g5scsc.
- A-834,735 sameAs Q4646879.
- A-834,735 sameAs Q4646879.
- A-834,735 wasDerivedFrom A-834,735?oldid=589910514.
- A-834,735 depiction A-834735_structure.png.
- A-834,735 isPrimaryTopicOf A-834,735.