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- ABCB5 abstract "ATP-binding cassette sub-family B member 5 also known as P-glycoprotein ABCB5 is a plasma membrane-spanning protein that in humans is encoded by the ABCB5 gene. ABCB5 is an ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.More recently, the ABCB5 molecule has been shown to be functionally relevant to carcinogenesis, demonstrated in colorectal cancer where it was shown to act as a mediator of 5-FU patient chemoresistance, and had a further direct role in tumorigenesis shown by shRNA-mediated colorectal cancer cell-line ABCB5 knockdowns that impeded tumorigenesis in human-to-mouse xenografts. These data revealed multiple roles for ABCB5 in cancer progression and chemoresistance, making it an attractive target for combined therapy.".
- ABCB5 entrezgene "340273".
- ABCB5 wikiPageExternalLink b_viewarticle.php?3158333.
- ABCB5 wikiPageExternalLink 19725928.
- ABCB5 wikiPageID "8884213".
- ABCB5 wikiPageRevisionID "589911738".
- ABCB5 hasPhotoCollection ABCB5.
- ABCB5 subject Category:Tumor_markers.
- ABCB5 type Biomolecule.
- ABCB5 type Protein.
- ABCB5 type ProteinMolecule.
- ABCB5 type BiologicalObject.
- ABCB5 comment "ATP-binding cassette sub-family B member 5 also known as P-glycoprotein ABCB5 is a plasma membrane-spanning protein that in humans is encoded by the ABCB5 gene. ABCB5 is an ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma.".
- ABCB5 label "ABCB5".
- ABCB5 sameAs m.027n6s7.
- ABCB5 sameAs Q4650058.
- ABCB5 sameAs Q4650058.
- ABCB5 wasDerivedFrom ABCB5?oldid=589911738.
- ABCB5 isPrimaryTopicOf ABCB5.