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- ABCC5 abstract "Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene.The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.".
- ABCC5 entrezgene "10057".
- ABCC5 wikiPageID "14765800".
- ABCC5 wikiPageRevisionID "589913548".
- ABCC5 hasPhotoCollection ABCC5.
- ABCC5 requireManualInspection "no".
- ABCC5 summaryText "The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.".
- ABCC5 updateCitations "yes".
- ABCC5 updatePage "yes".
- ABCC5 updateProteinBox "yes".
- ABCC5 updateSummary "yes".
- ABCC5 subject Category:ABC_transporters.
- ABCC5 type Biomolecule.
- ABCC5 type Protein.
- ABCC5 type BiologicalObject.
- ABCC5 comment "Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene.The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance.".
- ABCC5 label "ABCC5".
- ABCC5 sameAs m.03gx7rd.
- ABCC5 sameAs Q4650074.
- ABCC5 sameAs Q4650074.
- ABCC5 wasDerivedFrom ABCC5?oldid=589913548.
- ABCC5 isPrimaryTopicOf ABCC5.