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- ABCC8 abstract "ATP-binding cassette transporter sub-family C member 8 is a protein that in humans is encoded by the ABCC8 gene. ABCC8 orthologs have been identified in all mammals for which complete genome data are available.The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.".
- ABCC8 entrezgene "6833".
- ABCC8 wikiPageExternalLink NBK1375.
- ABCC8 wikiPageExternalLink br.fcgi?book=gene&part=dmn.
- ABCC8 wikiPageID "14602557".
- ABCC8 wikiPageRevisionID "589913562".
- ABCC8 hasPhotoCollection ABCC8.
- ABCC8 requireManualInspection "no".
- ABCC8 summaryText "The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.".
- ABCC8 updateCitations "yes".
- ABCC8 updatePage "yes".
- ABCC8 updateProteinBox "yes".
- ABCC8 updateSummary "yes".
- ABCC8 subject Category:ABC_transporters.
- ABCC8 type Biomolecule.
- ABCC8 type Protein.
- ABCC8 type BiologicalObject.
- ABCC8 comment "ATP-binding cassette transporter sub-family C member 8 is a protein that in humans is encoded by the ABCC8 gene. ABCC8 orthologs have been identified in all mammals for which complete genome data are available.The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.".
- ABCC8 label "ABCC8".
- ABCC8 sameAs m.03d96_z.
- ABCC8 sameAs Q4650075.
- ABCC8 sameAs Q4650075.
- ABCC8 sameAs ABCC8.
- ABCC8 sameAs SUR1.
- ABCC8 sameAs 230.
- ABCC8 wasDerivedFrom ABCC8?oldid=589913562.
- ABCC8 isPrimaryTopicOf ABCC8.