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- ACTL6A abstract "Actin-like protein 6A is a protein that in humans is encoded by the ACTL6A gene.This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.".
- ACTL6A entrezgene "86".
- ACTL6A wikiPageID "14756720".
- ACTL6A wikiPageRevisionID "602988123".
- ACTL6A hasPhotoCollection ACTL6A.
- ACTL6A requireManualInspection "no".
- ACTL6A summaryText "This gene encodes a family member of actin-related proteins , which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.".
- ACTL6A updateCitations "yes".
- ACTL6A updatePage "yes".
- ACTL6A updateProteinBox "yes".
- ACTL6A updateSummary "yes".
- ACTL6A subject Category:Human_proteins.
- ACTL6A type Biomolecule.
- ACTL6A type Protein.
- ACTL6A type BiologicalObject.
- ACTL6A comment "Actin-like protein 6A is a protein that in humans is encoded by the ACTL6A gene.This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling.".
- ACTL6A label "ACTL6A".
- ACTL6A label "ACTL6A".
- ACTL6A sameAs ACTL6A.
- ACTL6A sameAs m.03gww8b.
- ACTL6A sameAs Q8182782.
- ACTL6A sameAs Q8182782.
- ACTL6A wasDerivedFrom ACTL6A?oldid=602988123.
- ACTL6A isPrimaryTopicOf ACTL6A.