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- AM-1241 abstract "AM-1241 (1-(methylpiperidin-2-ylmethyl)-3-(2-iodo-5-nitrobenzoyl)indole) is a chemical from the aminoalkylindole family that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 3.4nM at CB2 and 80x selectivity over the related CB1 receptor. It has analgesic effects in animal studies, particularly against "atypical" pain such as hyperalgesia and allodynia. This is thought to be mediated through CB2-mediated peripheral release of endogeous opioid peptides, as well as direct activation of the TRPA1 channel. It has also shown efficacy in the treatment of amyotrophic lateral sclerosis in animal models.".
- AM-1241 casNumber "444912-48-5".
- AM-1241 iupacName "(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone".
- AM-1241 pubchem "10141893".
- AM-1241 thumbnail AM-1241-2D-skeletal.svg?width=300.
- AM-1241 wikiPageID "22817684".
- AM-1241 wikiPageRevisionID "590554371".
- AM-1241 c "22".
- AM-1241 casNumber "444912".
- AM-1241 chembl "408430".
- AM-1241 chemspiderid "8317404".
- AM-1241 h "22".
- AM-1241 hasPhotoCollection AM-1241.
- AM-1241 i "1".
- AM-1241 iupacName "-[1-[methyl]indol-3-yl]methanone".
- AM-1241 legalStatus "Legal".
- AM-1241 molecularWeight "503.333".
- AM-1241 n "3".
- AM-1241 o "3".
- AM-1241 pubchem "10141893".
- AM-1241 smiles "Ic2ccccc2Cccn1CC3CCCCN3C".
- AM-1241 stdinchi "1".
- AM-1241 stdinchikey "ZUHIXXCLLBMBDW-UHFFFAOYSA-N".
- AM-1241 verifiedfields "changed".
- AM-1241 verifiedrevid "477235775".
- AM-1241 subject Category:AM_cannabinoids.
- AM-1241 subject Category:Aminoalkylindoles.
- AM-1241 subject Category:Benzoylindoles.
- AM-1241 subject Category:Cannabinoids.
- AM-1241 subject Category:Designer_drugs.
- AM-1241 subject Category:Nitrobenzenes.
- AM-1241 subject Category:Organoiodides.
- AM-1241 subject Category:Piperidines.
- AM-1241 type Drug.
- AM-1241 type DrugProduct.
- AM-1241 type FunctionalSubstance.
- AM-1241 comment "AM-1241 (1-(methylpiperidin-2-ylmethyl)-3-(2-iodo-5-nitrobenzoyl)indole) is a chemical from the aminoalkylindole family that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 3.4nM at CB2 and 80x selectivity over the related CB1 receptor. It has analgesic effects in animal studies, particularly against "atypical" pain such as hyperalgesia and allodynia.".
- AM-1241 label "AM-1241".
- AM-1241 sameAs m.06410hz.
- AM-1241 sameAs Q4652487.
- AM-1241 sameAs Q4652487.
- AM-1241 wasDerivedFrom AM-1241?oldid=590554371.
- AM-1241 depiction AM-1241-2D-skeletal.svg.
- AM-1241 isPrimaryTopicOf AM-1241.