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- AP_endonuclease abstract "Apurinic/apyrimidinic (AP) endonuclease (BRENDA = 4.2.99.18) is an enzyme that is involved in the DNA base excision repair pathway (BER). Its main role in the repair of damaged or mismatched nucleotides in DNA is to create a nick in the phosphodiester backbone of the AP site created when DNA glycosylase removes the damaged base.There are four types of AP endonucleases that have been classified according to their sites of incision. Class I and class II AP endonucleases incise DNA at the phosphate groups 3´ and 5´ to the baseless site leaving 3´-OH and 5´-phosphate termini. Class III and class IV AP endonucleases also cleave DNA at the phosphate groups 3´ and 5´to the baseless site, but they generate a 3´-phosphate and a 5´-OH.Human AP Endonuclease (APE1), like most AP endonucleases, is of class II and requires an Mg2+ in its active site in order to carry out its role in base excision repair. The yeast homolog of this enzyme is APN1.".
- AP_endonuclease thumbnail ApEndonuclease1.jpg?width=300.
- AP_endonuclease wikiPageExternalLink AP_endonuclease.html.
- AP_endonuclease wikiPageExternalLink PDOC00598.
- AP_endonuclease wikiPageExternalLink PDOC00599.
- AP_endonuclease wikiPageExternalLink 3405.
- AP_endonuclease wikiPageExternalLink 41715.
- AP_endonuclease wikiPageID "2953206".
- AP_endonuclease wikiPageRevisionID "594660999".
- AP_endonuclease hasPhotoCollection AP_endonuclease.
- AP_endonuclease subject Category:Enzymes.
- AP_endonuclease type Abstraction100002137.
- AP_endonuclease type Activator114723079.
- AP_endonuclease type Catalyst114723628.
- AP_endonuclease type Chemical114806838.
- AP_endonuclease type Compound114818238.
- AP_endonuclease type Enzyme114732946.
- AP_endonuclease type Enzymes.
- AP_endonuclease type Macromolecule114944888.
- AP_endonuclease type Material114580897.
- AP_endonuclease type Matter100020827.
- AP_endonuclease type Molecule114682133.
- AP_endonuclease type OrganicCompound114727670.
- AP_endonuclease type Part113809207.
- AP_endonuclease type PhysicalEntity100001930.
- AP_endonuclease type Protein114728724.
- AP_endonuclease type Relation100031921.
- AP_endonuclease type Substance100019613.
- AP_endonuclease type Thing100002452.
- AP_endonuclease type Unit109465459.
- AP_endonuclease comment "Apurinic/apyrimidinic (AP) endonuclease (BRENDA = 4.2.99.18) is an enzyme that is involved in the DNA base excision repair pathway (BER). Its main role in the repair of damaged or mismatched nucleotides in DNA is to create a nick in the phosphodiester backbone of the AP site created when DNA glycosylase removes the damaged base.There are four types of AP endonucleases that have been classified according to their sites of incision.".
- AP_endonuclease label "AP endonuclease".
- AP_endonuclease sameAs m.08fvb3.
- AP_endonuclease sameAs Q4653506.
- AP_endonuclease sameAs Q4653506.
- AP_endonuclease sameAs AP_endonuclease.
- AP_endonuclease wasDerivedFrom AP_endonuclease?oldid=594660999.
- AP_endonuclease depiction ApEndonuclease1.jpg.
- AP_endonuclease isPrimaryTopicOf AP_endonuclease.
