Matches in DBpedia 2014 for { <http://dbpedia.org/resource/ASCL1> ?p ?o. }
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- ASCL1 abstract "Achaete-scute homolog 1 is a protein that in humans is encoded by the ASCL1 gene. Because it was discovered subsequent to studies on its homolog in Drosophila, the Achaete-scute complex, it was originally named MASH-1 for mammalian achaete scute homolog-1.This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. It is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests that it may also play a role in tumor formation.".
- ASCL1 entrezgene "429".
- ASCL1 wikiPageID "14771355".
- ASCL1 wikiPageRevisionID "603318360".
- ASCL1 hasPhotoCollection ASCL1.
- ASCL1 inhibits Notch_signaling_pathway.
- ASCL1 requireManualInspection "no".
- ASCL1 summaryText "This gene encodes a member of the basic helix-loop-helix family of transcription factors. The protein activates transcription by binding to the E box . Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. It is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests that it may also play a role in tumor formation.".
- ASCL1 updateCitations "yes".
- ASCL1 updatePage "yes".
- ASCL1 updateProteinBox "yes".
- ASCL1 updateSummary "yes".
- ASCL1 subject Category:Transcription_factors.
- ASCL1 type Biomolecule.
- ASCL1 type Protein.
- ASCL1 type BiologicalObject.
- ASCL1 comment "Achaete-scute homolog 1 is a protein that in humans is encoded by the ASCL1 gene. Because it was discovered subsequent to studies on its homolog in Drosophila, the Achaete-scute complex, it was originally named MASH-1 for mammalian achaete scute homolog-1.This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3').".
- ASCL1 label "ASCL1".
- ASCL1 sameAs m.03gxfw2.
- ASCL1 sameAs Q4654121.
- ASCL1 sameAs Q4654121.
- ASCL1 wasDerivedFrom ASCL1?oldid=603318360.
- ASCL1 isPrimaryTopicOf ASCL1.