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- ATP:guanido_phosphotransferase_family abstract "In molecular biology, the ATP:guanido phosphotransferase family is a family of structurally and functionally related enzymes, that reversibly catalyse the transfer of phosphate between ATP and various phosphogens. The enzymes belonging to this family include:Glycocyamine kinase (EC 2.7.3.1), which catalyses the transfer of phosphate from ATP to guanidoacetate.Arginine kinase (EC 2.7.3.3), which catalyses the transfer of phosphate from ATP to arginine.Taurocyamine kinase (EC 2.7.3.4), an annelid-specific enzyme that catalyses the transfer of phosphate from ATP to taurocyamine.Lombricine kinase (EC 2.7.3.5), an annelid-specific enzyme that catalyses the transfer of phosphate from ATP to lombricine.Smc74, a cercaria-specific enzyme from Schistosoma mansoni.Creatine kinase (EC 2.7.3.2) (CK), which catalyses the reversible transfer of high energy phosphate from ATP to creatine, generating phosphocreatine and ADP.Creatine kinase plays an important role in energy metabolism of vertebrates. There are at least four different, but very closely related, forms of CK. Two isozymes, M (muscle) and B (brain), are cytosolic, while the other two are mitochondrial. In sea urchins there is a flagellar isozyme, which consists of the triplication of a CK-domain. A cysteine residue is implicated in the catalytic activity of these enzymes and the region around this active site residue is highly conserved.ATP:guanido phosphotransferases contain a C-terminal catalytic domain which consists of a duplication where the common core consists of two beta-alpha-beta2-alpha repeats. The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain. They also contain an N-terminal domain which has an all-alpha fold consisting of an irregular array of 6 short helices.".
- ATP:guanido_phosphotransferase_family symbol "ATP-gua_Ptrans".
- ATP:guanido_phosphotransferase_family symbol "ATP-gua_PtransN".
- ATP:guanido_phosphotransferase_family thumbnail PDB_1sd0_EBI.jpg?width=300.
- ATP:guanido_phosphotransferase_family wikiPageID "32149776".
- ATP:guanido_phosphotransferase_family wikiPageRevisionID "590713559".
- ATP:guanido_phosphotransferase_family caption "structure of arginine kinase c271a mutant".
- ATP:guanido_phosphotransferase_family caption "transition state structure of an arginine kinase mutant".
- ATP:guanido_phosphotransferase_family hasPhotoCollection ATP:guanido_phosphotransferase_family.
- ATP:guanido_phosphotransferase_family interpro "IPR022413".
- ATP:guanido_phosphotransferase_family interpro "IPR022414".
- ATP:guanido_phosphotransferase_family name "ATP:guanido phosphotransferase N-terminal domain".
- ATP:guanido_phosphotransferase_family name "ATP:guanido phosphotransferase catalytic domain".
- ATP:guanido_phosphotransferase_family pfam "PF00217".
- ATP:guanido_phosphotransferase_family pfam "PF02807".
- ATP:guanido_phosphotransferase_family pfamClan "CL0286".
- ATP:guanido_phosphotransferase_family prosite "PDOC00103".
- ATP:guanido_phosphotransferase_family scop "1".
- ATP:guanido_phosphotransferase_family symbol "ATP-gua_Ptrans".
- ATP:guanido_phosphotransferase_family symbol "ATP-gua_PtransN".
- ATP:guanido_phosphotransferase_family subject Category:Protein_domains.
- ATP:guanido_phosphotransferase_family type Biomolecule.
- ATP:guanido_phosphotransferase_family type Protein.
- ATP:guanido_phosphotransferase_family type BiologicalObject.
- ATP:guanido_phosphotransferase_family comment "In molecular biology, the ATP:guanido phosphotransferase family is a family of structurally and functionally related enzymes, that reversibly catalyse the transfer of phosphate between ATP and various phosphogens.".
- ATP:guanido_phosphotransferase_family label "ATP:guanido phosphotransferase family".
- ATP:guanido_phosphotransferase_family sameAs m.0gx07ct.
- ATP:guanido_phosphotransferase_family sameAs Q4654861.
- ATP:guanido_phosphotransferase_family sameAs Q4654861.
- ATP:guanido_phosphotransferase_family wasDerivedFrom ATP:guanido_phosphotransferase_family?oldid=590713559.
- ATP:guanido_phosphotransferase_family depiction PDB_1sd0_EBI.jpg.
- ATP:guanido_phosphotransferase_family isPrimaryTopicOf ATP:guanido_phosphotransferase_family.