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- ATP6V0B abstract "V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.".
- ATP6V0B entrezgene "533".
- ATP6V0B wikiPageID "14874958".
- ATP6V0B wikiPageRevisionID "606625151".
- ATP6V0B hasPhotoCollection ATP6V0B.
- ATP6V0B requireManualInspection "no".
- ATP6V0B summaryText "This gene encodes a component of vacuolar ATPase , a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.".
- ATP6V0B updateCitations "yes".
- ATP6V0B updatePage "yes".
- ATP6V0B updateProteinBox "yes".
- ATP6V0B updateSummary "yes".
- ATP6V0B type Biomolecule.
- ATP6V0B type Protein.
- ATP6V0B type BiologicalObject.
- ATP6V0B comment "V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation.".
- ATP6V0B label "ATP6V0B".
- ATP6V0B sameAs m.03g_v51.
- ATP6V0B sameAs Q4654838.
- ATP6V0B sameAs Q4654838.
- ATP6V0B wasDerivedFrom ATP6V0B?oldid=606625151.
- ATP6V0B isPrimaryTopicOf ATP6V0B.