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- AU-rich_element abstract "Adenylate-uridylate-rich elements (AU-rich elements; AREs) are found in the 3' untranslated region (UTR) of many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription factors, and cytokines. AREs are one of the most common determinants of RNA stability in mammalian cells.AREs are defined as a region with frequent adenine and uridine bases in a mRNA. They usually target the mRNA for degradation.ARE-directed mRNA degradation is influenced by many exogenous factors, including phorbol esters, calcium ionophores, cytokines, and transcription inhibitors. These observations suggest that AREs play a critical role in the regulation of gene transcription during cell growth and differentiation, and the immune response.AREs have been divided into three classes with different sequences. The best characterised Adenylate Uridylate (AU)-rich Elements have a core sequence of AUUUA within U rich sequences (for example WWWU(AUUUA)UUUW where W is A or U). This lies within a 50-150 base sequence, repeats of the core AUUUA element are often required for function. A number of different proteins (e.g. HuA, HuB, HuC, HuD, HuR) bind to these elements and stabilise the mRNA while others (AUF1, TTP, BRF1, TIA-1, TIAR, and KSRP) destabilise the mRNA, miRNAs may also bind to some of them. HuD (also calledELAVL4) binds to AREs and increases the half-life of ARE-bearing mRNAs in neurons during brain development and plasticity.AREsite - a database for ARE containing genes - has recently been developed with the aim to provide detailed bioinformatic characterization of AU-rich elements.".
- AU-rich_element wikiPageExternalLink ARED.
- AU-rich_element wikiPageExternalLink RNAMotif?PatID=T0024.
- AU-rich_element wikiPageExternalLink AREsite.cgi.
- AU-rich_element wikiPageExternalLink RNAMotif.html.
- AU-rich_element wikiPageExternalLink abstract?uid=PII0092867486903417.
- AU-rich_element wikiPageExternalLink 852.
- AU-rich_element wikiPageID "16286691".
- AU-rich_element wikiPageRevisionID "603444505".
- AU-rich_element hasPhotoCollection AU-rich_element.
- AU-rich_element subject Category:Cis-regulatory_RNA_elements.
- AU-rich_element subject Category:Gene_expression.
- AU-rich_element subject Category:RNA.
- AU-rich_element type Abstraction100002137.
- AU-rich_element type Cis-regulatoryRNAElements.
- AU-rich_element type Cognition100023271.
- AU-rich_element type Component105868954.
- AU-rich_element type Concept105835747.
- AU-rich_element type Content105809192.
- AU-rich_element type Idea105833840.
- AU-rich_element type Part105867413.
- AU-rich_element type PsychologicalFeature100023100.
- AU-rich_element comment "Adenylate-uridylate-rich elements (AU-rich elements; AREs) are found in the 3' untranslated region (UTR) of many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription factors, and cytokines. AREs are one of the most common determinants of RNA stability in mammalian cells.AREs are defined as a region with frequent adenine and uridine bases in a mRNA.".
- AU-rich_element label "AU-rich element".
- AU-rich_element sameAs m.03wg1nc.
- AU-rich_element sameAs Q4654967.
- AU-rich_element sameAs Q4654967.
- AU-rich_element sameAs AU-rich_element.
- AU-rich_element wasDerivedFrom AU-rich_element?oldid=603444505.
- AU-rich_element isPrimaryTopicOf AU-rich_element.