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- Acitretin abstract "Acitretin (trade name Soriatane or Neotigason) is a second-generation retinoid. It is taken orally, and is typically used for psoriasis.It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days. However, because acitretin can be reverse metabolised into etretinate which has an extremely long half-life, women must avoid becoming pregnant for at least 3 years after discontinuing acitretin. Therefore, acitretin is generally not recommended for women of child-bearing age with a risk of becoming pregnant.Acitretin is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects it is generally used in only very severe cases of psoriasis that have been unresponsive to other treatments. It binds to nuclear receptors that regulates gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia, leading to the slowing of cell reproduction. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after 2 to 4 weeks or longer.Patients that have received the medication are advised against giving blood for at least 3 years due to the risk of birth defects.".
- Acitretin atcPrefix "D05".
- Acitretin atcSuffix "BB02".
- Acitretin bioavailability "60.0".
- Acitretin casNumber "55079-83-9".
- Acitretin chEBI "50173".
- Acitretin drugbank "DB00459".
- Acitretin fdaUniiCode "LCH760E9T7".
- Acitretin iupacName "(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid".
- Acitretin pubchem "5284513".
- Acitretin thumbnail Acitretin2DACS.svg?width=300.
- Acitretin wikiPageID "1300834".
- Acitretin wikiPageRevisionID "590345039".
- Acitretin atcPrefix "D05".
- Acitretin atcSuffix "BB02".
- Acitretin bioavailability "60.0".
- Acitretin c "21".
- Acitretin casNumber "55079".
- Acitretin chebi "50173".
- Acitretin chembl "1131".
- Acitretin chemspiderid "4447573".
- Acitretin drugbank "DB00459".
- Acitretin eliminationHalfLife "176400.0".
- Acitretin excretion "Faeces & urine".
- Acitretin h "26".
- Acitretin hasPhotoCollection Acitretin.
- Acitretin inchi "1".
- Acitretin inchikey "IHUNBGSDBOWDMA-AQFIFDHZBN".
- Acitretin iupacName "-9".
- Acitretin kegg "D02754".
- Acitretin legalAu "S4".
- Acitretin legalCa "Rx-only".
- Acitretin legalUk "POM".
- Acitretin legalUs "Rx-only".
- Acitretin medlineplus "a601010".
- Acitretin metabolism "Hepatic".
- Acitretin molecularWeight "326.429".
- Acitretin o "3".
- Acitretin pregnancyAu "X".
- Acitretin pregnancyUs "X".
- Acitretin proteinBound ">99.9%".
- Acitretin pubchem "5284513".
- Acitretin routesOfAdministration "Oral".
- Acitretin smiles "O=C\C=CC".
- Acitretin stdinchi "1".
- Acitretin stdinchikey "IHUNBGSDBOWDMA-AQFIFDHZSA-N".
- Acitretin tradename "Soriatane".
- Acitretin unii "LCH760E9T7".
- Acitretin verifiedrevid "477240755".
- Acitretin subject Category:Phenol_ethers.
- Acitretin subject Category:Retinoids.
- Acitretin type Abstraction100002137.
- Acitretin type Element114840755.
- Acitretin type Matter100020827.
- Acitretin type Part113809207.
- Acitretin type PhenolEthers.
- Acitretin type PhysicalEntity100001930.
- Acitretin type Quintessence114847103.
- Acitretin type Relation100031921.
- Acitretin type Substance100019613.
- Acitretin type Drug.
- Acitretin type DrugProduct.
- Acitretin type FunctionalSubstance.
- Acitretin comment "Acitretin (trade name Soriatane or Neotigason) is a second-generation retinoid. It is taken orally, and is typically used for psoriasis.It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.".
- Acitretin label "Acitretin".
- Acitretin label "Acitretin".
- Acitretin label "Acitretina".
- Acitretin label "Acitretina".
- Acitretin label "Acitretine".
- Acitretin label "Acitrétine".
- Acitretin label "Acytretyna".
- Acitretin label "أسيتريتين".
- Acitretin sameAs Acitretin.
- Acitretin sameAs Acitrétine.
- Acitretin sameAs Acitretina.
- Acitretin sameAs 아시트레틴.
- Acitretin sameAs Acitretine.
- Acitretin sameAs Acytretyna.
- Acitretin sameAs Acitretina.
- Acitretin sameAs m.04r3nh.
- Acitretin sameAs Q341500.
- Acitretin sameAs Q341500.
- Acitretin sameAs ACITRETIN.
- Acitretin sameAs DB00459.
- Acitretin sameAs 41317.
- Acitretin sameAs Acitretin.
- Acitretin wasDerivedFrom Acitretin?oldid=590345039.
- Acitretin depiction Acitretin2DACS.svg.
- Acitretin isPrimaryTopicOf Acitretin.